Record Information |
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Version | 5.0 |
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Status | Detected but not Quantified |
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Creation Date | 2012-09-11 19:06:26 UTC |
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Update Date | 2023-02-21 17:24:09 UTC |
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HMDB ID | HMDB0034301 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Piperidine |
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Description | Piperidine is an organic compound with the molecular formula (CH2)5NH. This heterocyclic amine consists of a six-membered ring containing five methylene units and one nitrogen atom. Piperdine is a member of the class of compounds known as azacycloalkane. An azacyloalkane is cyclohexane in which one of the carbons is replaced by a nitrogen. Piperdine is a naturally occurring metabolite in the human body. In particular, it is a metabolite of cadaverine, a polyamine found in the human intestine and other mammalian intestines (PMID: 6406679 ). Piperidine is considered to be a microbial metabolite. Piperdine can be isolated from a variety of natural sources or synthesized in the lab and exists as a colorless fuming liquid with an odor described as ammoniacal or pepper-like. The name piperdine comes from the genus name Piper, which is the Latin word for pepper. Piperidine is found in a number of plants including black pepper (Piper nigrum), celery plants, bell peppers and tobacco. The piperidine structural motif is present in numerous natural alkaloids. These include piperine, which gives black pepper its spicy taste. In food, piperidine is a flavouring agent and it is also widely used as a building block and chemical reagent in the synthesis of organic compounds, including pharmaceuticals. As a liquid, piperidine is used as a solvent and as a base. |
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Structure | InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2 |
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Synonyms | Value | Source |
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Azacyclohexane | ChEBI | Azinane | ChEBI | Cyclopentimine | ChEBI | Cypentil | ChEBI | Hexahydropyridine | ChEBI | Hexazane | ChEBI | Pentamethyleneamine | ChEBI | Pentamethyleneimine | ChEBI | Pentamethylenimine | ChEBI | Perhydropyridine | ChEBI | pip | ChEBI | Piperidin | ChEBI | FEMA 2908 | HMDB | hexahydro-Pyridine | HMDB | Piperidine ON rasta resin | HMDB |
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Chemical Formula | C5H11N |
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Average Molecular Weight | 85.1475 |
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Monoisotopic Molecular Weight | 85.089149357 |
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IUPAC Name | piperidine |
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Traditional Name | piperidine |
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CAS Registry Number | 110-89-4 |
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SMILES | C1CCNCC1 |
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InChI Identifier | InChI=1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2 |
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InChI Key | NQRYJNQNLNOLGT-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as piperidines. Piperidines are compounds containing a piperidine ring, which is a saturated aliphatic six-member ring with one nitrogen atom and five carbon atoms. |
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Kingdom | Organic compounds |
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Super Class | Organoheterocyclic compounds |
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Class | Piperidines |
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Sub Class | Not Available |
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Direct Parent | Piperidines |
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Alternative Parents | |
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Substituents | - Piperidine
- Azacycle
- Secondary amine
- Secondary aliphatic amine
- Organic nitrogen compound
- Organopnictogen compound
- Hydrocarbon derivative
- Organonitrogen compound
- Amine
- Aliphatic heteromonocyclic compound
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Molecular Framework | Aliphatic heteromonocyclic compounds |
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External Descriptors | |
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Ontology |
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Physiological effect | |
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Disposition | |
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Process | Not Available |
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Role | |
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Physical Properties |
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State | Liquid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | -9 °C | Not Available | Boiling Point | 106.00 to 107.00 °C. @ 760.00 mm Hg | The Good Scents Company Information System | Water Solubility | 1000 mg/mL at 20 °C | Not Available | LogP | 0.84 | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedDerivatized |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental GC-MS | GC-MS Spectrum - Piperidine EI-B (Non-derivatized) | splash10-0543-9000000000-6b1887859e5474352d6e | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Piperidine EI-B (Non-derivatized) | splash10-053u-9000000000-507e3f9eabf271f642f3 | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Piperidine EI-B (Non-derivatized) | splash10-0563-9000000000-c08d3d67e81c397678d2 | 2017-09-12 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Piperidine EI-B (Non-derivatized) | splash10-0543-9000000000-6b1887859e5474352d6e | 2018-05-18 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Piperidine EI-B (Non-derivatized) | splash10-053u-9000000000-507e3f9eabf271f642f3 | 2018-05-18 | HMDB team, MONA, MassBank | View Spectrum | Experimental GC-MS | GC-MS Spectrum - Piperidine EI-B (Non-derivatized) | splash10-0563-9000000000-c08d3d67e81c397678d2 | 2018-05-18 | HMDB team, MONA, MassBank | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Piperidine GC-MS (Non-derivatized) - 70eV, Positive | splash10-052u-9000000000-95f068cd42017a2e7446 | 2016-09-22 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Piperidine GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Piperidine GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | MS | Mass Spectrum (Electron Ionization) | splash10-053u-9000000000-9b296a6ad56d186eee6f | 2015-03-01 | Not Available | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine LC-ESI-QQ , positive-QTOF | splash10-000i-9000000000-a76c8bf8d69f5f3e831a | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine LC-ESI-QQ , positive-QTOF | splash10-000i-9000000000-fe1ffe6a62bbbfa35a46 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine LC-ESI-QQ , positive-QTOF | splash10-000i-9000000000-c57e3de57c466c728f49 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine LC-ESI-QQ , positive-QTOF | splash10-000f-9000000000-7936721ae1a323f2cd83 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine LC-ESI-QQ , positive-QTOF | splash10-000f-9000000000-6bcb90141de97851b0ce | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine LC-ESI-QTOF , positive-QTOF | splash10-000i-9000000000-155786c0621c522e75a7 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-014i-9000000000-646cb2a227fa351da3dc | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-014i-9000000000-32222dc7a0d132edf443 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-014i-9000000000-646cb2a227fa351da3dc | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-014i-9000000000-071a5573608ae27993d5 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-014i-9000000000-80fe3a58dda39ff48e6f | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-000i-9000000000-544d5b027d322e9b7a06 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-000i-9000000000-544d5b027d322e9b7a06 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-000i-9000000000-544d5b027d322e9b7a06 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-000i-9000000000-1a5edb15988820bf46f7 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-000i-9000000000-79404da79119ad6ba660 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-000i-9000000000-f83e1ccbb9745637eb97 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-000i-9000000000-348e151611d5b46f3a33 | 2017-09-14 | HMDB team, MONA | View Spectrum | Experimental LC-MS/MS | LC-MS/MS Spectrum - Piperidine ESI-ITFT , positive-QTOF | splash10-000i-9000000000-8c4547384f2bc29d797b | 2017-09-14 | HMDB team, MONA | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Piperidine 10V, Positive-QTOF | splash10-000i-9000000000-bd6d487d25b0e623403e | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Piperidine 20V, Positive-QTOF | splash10-000i-9000000000-d9b236846b0611684014 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Piperidine 40V, Positive-QTOF | splash10-00ku-9000000000-508b10b77d98c3915247 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Piperidine 10V, Negative-QTOF | splash10-001i-9000000000-b616957223f2d18551fd | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Piperidine 20V, Negative-QTOF | splash10-001i-9000000000-a2e05ca3b5d63ce6a366 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Piperidine 40V, Negative-QTOF | splash10-015c-9000000000-49c805d2b27473cc8f88 | 2016-08-03 | Wishart Lab | View Spectrum |
NMR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Predicted 1D NMR | 13C NMR Spectrum (1D, 100 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 100 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 1000 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 1000 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 200 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 200 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 300 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 300 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 400 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 400 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 500 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 500 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 600 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 600 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 700 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 700 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 800 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 800 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 13C NMR Spectrum (1D, 900 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum | Predicted 1D NMR | 1H NMR Spectrum (1D, 900 MHz, H2O, predicted) | 2022-08-21 | Wishart Lab | View Spectrum |
IR SpectraSpectrum Type | Description | Deposition Date | Source | View |
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Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-) | 2023-02-04 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+) | 2023-02-04 | FELIX lab | View Spectrum | Predicted IR Spectrum | IR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+) | 2023-02-04 | FELIX lab | View Spectrum |
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Disease References | Colorectal cancer |
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- Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016. [PubMed:27275383 ]
| Metastatic melanoma |
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- Frankel AE, Coughlin LA, Kim J, Froehlich TW, Xie Y, Frenkel EP, Koh AY: Metagenomic Shotgun Sequencing and Unbiased Metabolomic Profiling Identify Specific Human Gut Microbiota and Metabolites Associated with Immune Checkpoint Therapy Efficacy in Melanoma Patients. Neoplasia. 2017 Oct;19(10):848-855. doi: 10.1016/j.neo.2017.08.004. Epub 2017 Sep 15. [PubMed:28923537 ]
| Perillyl alcohol administration for cancer treatment |
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- Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10. [PubMed:20300169 ]
| Pancreatic cancer |
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- Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10. [PubMed:20300169 ]
| Periodontal disease |
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- Sugimoto M, Wong DT, Hirayama A, Soga T, Tomita M: Capillary electrophoresis mass spectrometry-based saliva metabolomics identified oral, breast and pancreatic cancer-specific profiles. Metabolomics. 2010 Mar;6(1):78-95. Epub 2009 Sep 10. [PubMed:20300169 ]
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General References | - De Marco A, De Candia M, Carotti A, Cellamare S, De Candia E, Altomare C: Lipophilicity-related inhibition of blood platelet aggregation by nipecotic acid anilides. Eur J Pharm Sci. 2004 Jun;22(2-3):153-64. [PubMed:15158900 ]
- Dembitsky VM: Astonishing diversity of natural surfactants: 6. Biologically active marine and terrestrial alkaloid glycosides. Lipids. 2005 Nov;40(11):1081-105. [PubMed:16459921 ]
- Aisaka K, Hattori Y, Ishihara T, Morita M, Kase Y, Miyata T: The effects of piperidine and its related substances on blood vessels. Jpn J Pharmacol. 1985 Apr;37(4):345-53. [PubMed:4010086 ]
- Patel K, Chen Y, Dennehy K, Blau J, Connors S, Mendonca M, Tarpey M, Krishna M, Mitchell JB, Welch WJ, Wilcox CS: Acute antihypertensive action of nitroxides in the spontaneously hypertensive rat. Am J Physiol Regul Integr Comp Physiol. 2006 Jan;290(1):R37-43. Epub 2005 Sep 22. [PubMed:16179488 ]
- Nishi K, Iwasaki K, Kase Y: Actions of piperidine and dimethylphenylpiperazinium (DMPP) on afferent discharges of the cat's carotid body. Eur J Pharmacol. 1979 Feb 15;54(1-2):141-52. [PubMed:421736 ]
- Nomura Y, Schmidt-Glenewinkel T, Giacobini E, Ortiz J: Metabolism of cadaverine and pipecolic acid in brain and other organs of the mouse. J Neurosci Res. 1983;9(3):279-89. doi: 10.1002/jnr.490090305. [PubMed:6406679 ]
- (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .
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