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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-11 21:36:00 UTC
Update Date2022-03-07 02:54:56 UTC
HMDB IDHMDB0036458
Secondary Accession Numbers
  • HMDB36458
Metabolite Identification
Common Name1-Aminocyclopropanecarboxylic acid
Description1-Aminocyclopropanecarboxylic acid, also known as ACC or 1-amino-1-carboxycyclopropane, belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon). 1-Aminocyclopropanecarboxylic acid exists in all living organisms, ranging from bacteria to humans. 1-Aminocyclopropanecarboxylic acid has been detected, but not quantified in, several different foods, such as green vegetables, black crowberries (Empetrum nigrum), prairie turnips (Pediomelum esculentum), small-leaf lindens (Tilia cordata), and carrots (Daucus carota ssp. sativus). This could make 1-aminocyclopropanecarboxylic acid a potential biomarker for the consumption of these foods. 1-Aminocyclopropanecarboxylic acid is a primary metabolite. Primary metabolites are metabolically or physiologically essential metabolites. They are directly involved in an organism’s growth, development or reproduction. Based on a literature review a significant number of articles have been published on 1-Aminocyclopropanecarboxylic acid.
Structure
Data?1563862879
Synonyms
ValueSource
1-Aminocyclopropane-1-carboxylic acidChEBI
ACCChEBI
1-Aminocyclopropane-1-carboxylateGenerator
1-AminocyclopropanecarboxylateGenerator
1-Amino-1-carboxycyclopropaneHMDB
1-Amino-cyclopropanecarboxylic acidHMDB
1-Aminocyclopropane-1-1-carboxylic acidHMDB
1-Aminocyclopropanecarboxylic acid hydrochlorideHMDB
ACPCHMDB
alpha-Aminocyclopropane carboxylic acidHMDB
alpha-Aminocyclopropanecarboxylic acidHMDB
Aminocyclopropane carboxylic acidHMDB
1-Aminocyclopropane-1-carboxylic acid hydrochlorideHMDB
ACC acidHMDB
1-Aminocyclopropane-1-carboxylic acid, 14C-labeledHMDB
1-Aminocyclopropane carboxylic acidHMDB
Chemical FormulaC4H7NO2
Average Molecular Weight101.1039
Monoisotopic Molecular Weight101.047678473
IUPAC Name1-aminocyclopropane-1-carboxylic acid
Traditional Name1-aminocyclopropane-1-carboxylic acid
CAS Registry Number22059-21-8
SMILES
NC1(CC1)C(O)=O
InChI Identifier
InChI=1S/C4H7NO2/c5-4(1-2-4)3(6)7/h1-2,5H2,(H,6,7)
InChI KeyPAJPWUMXBYXFCZ-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as alpha amino acids. These are amino acids in which the amino group is attached to the carbon atom immediately adjacent to the carboxylate group (alpha carbon).
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentAlpha amino acids
Alternative Parents
Substituents
  • Alpha-amino acid
  • 1-aminocyclopropane-1-carboxylic acid or derivatives
  • Cyclopropanecarboxylic acid
  • Cyclopropanecarboxylic acid or derivatives
  • Amino acid
  • Carboxylic acid
  • Monocarboxylic acid or derivatives
  • Organic nitrogen compound
  • Organooxygen compound
  • Organonitrogen compound
  • Primary amine
  • Primary aliphatic amine
  • Hydrocarbon derivative
  • Organic oxide
  • Organopnictogen compound
  • Carbonyl group
  • Amine
  • Organic oxygen compound
  • Aliphatic homomonocyclic compound
Molecular FrameworkAliphatic homomonocyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point229 - 231 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-2.78Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility437 g/LALOGPS
logP-3ALOGPS
logP-2.7ChemAxon
logS0.64ALOGPS
pKa (Strongest Acidic)2.2ChemAxon
pKa (Strongest Basic)9.35ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count3ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area63.32 ŲChemAxon
Rotatable Bond Count1ChemAxon
Refractivity23.25 m³·mol⁻¹ChemAxon
Polarizability9.6 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+119.15831661259
DarkChem[M-H]-111.95131661259
DeepCCS[M+H]+122.11130932474
DeepCCS[M-H]-119.31230932474
DeepCCS[M-2H]-155.64530932474
DeepCCS[M+Na]+130.26430932474
AllCCS[M+H]+124.232859911
AllCCS[M+H-H2O]+119.632859911
AllCCS[M+NH4]+128.632859911
AllCCS[M+Na]+129.832859911
AllCCS[M-H]-117.532859911
AllCCS[M+Na-2H]-120.632859911
AllCCS[M+HCOO]-124.232859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
1-Aminocyclopropanecarboxylic acidNC1(CC1)C(O)=O1844.1Standard polar33892256
1-Aminocyclopropanecarboxylic acidNC1(CC1)C(O)=O994.1Standard non polar33892256
1-Aminocyclopropanecarboxylic acidNC1(CC1)C(O)=O1424.0Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
1-Aminocyclopropanecarboxylic acid,1TMS,isomer #1C[Si](C)(C)OC(=O)C1(N)CC11008.9Semi standard non polar33892256
1-Aminocyclopropanecarboxylic acid,1TMS,isomer #2C[Si](C)(C)NC1(C(=O)O)CC11148.4Semi standard non polar33892256
1-Aminocyclopropanecarboxylic acid,2TMS,isomer #1C[Si](C)(C)NC1(C(=O)O[Si](C)(C)C)CC11176.3Semi standard non polar33892256
1-Aminocyclopropanecarboxylic acid,2TMS,isomer #1C[Si](C)(C)NC1(C(=O)O[Si](C)(C)C)CC11257.2Standard non polar33892256
1-Aminocyclopropanecarboxylic acid,2TMS,isomer #2C[Si](C)(C)N(C1(C(=O)O)CC1)[Si](C)(C)C1360.9Semi standard non polar33892256
1-Aminocyclopropanecarboxylic acid,2TMS,isomer #2C[Si](C)(C)N(C1(C(=O)O)CC1)[Si](C)(C)C1311.0Standard non polar33892256
1-Aminocyclopropanecarboxylic acid,3TMS,isomer #1C[Si](C)(C)OC(=O)C1(N([Si](C)(C)C)[Si](C)(C)C)CC11390.3Semi standard non polar33892256
1-Aminocyclopropanecarboxylic acid,3TMS,isomer #1C[Si](C)(C)OC(=O)C1(N([Si](C)(C)C)[Si](C)(C)C)CC11401.0Standard non polar33892256
1-Aminocyclopropanecarboxylic acid,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)C1(N)CC11246.4Semi standard non polar33892256
1-Aminocyclopropanecarboxylic acid,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)NC1(C(=O)O)CC11431.4Semi standard non polar33892256
1-Aminocyclopropanecarboxylic acid,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC1(C(=O)O[Si](C)(C)C(C)(C)C)CC11636.7Semi standard non polar33892256
1-Aminocyclopropanecarboxylic acid,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)NC1(C(=O)O[Si](C)(C)C(C)(C)C)CC11693.6Standard non polar33892256
1-Aminocyclopropanecarboxylic acid,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)N(C1(C(=O)O)CC1)[Si](C)(C)C(C)(C)C1805.2Semi standard non polar33892256
1-Aminocyclopropanecarboxylic acid,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)N(C1(C(=O)O)CC1)[Si](C)(C)C(C)(C)C1767.9Standard non polar33892256
1-Aminocyclopropanecarboxylic acid,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)C1(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)CC12028.6Semi standard non polar33892256
1-Aminocyclopropanecarboxylic acid,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)C1(N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)CC12066.5Standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-MS (1 TMS)splash10-001i-9500000000-33713ec79986844e54732014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-MS (2 TMS)splash10-0ufr-3950000000-776d858758510d8fe3b82014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-MS (3 TMS)splash10-00di-1910000000-acee5ab7198285e8e50d2014-06-16HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-EI-TOF (Non-derivatized)splash10-0002-1910000000-836cd3fd9e3e118fac612017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-EI-TOF (Non-derivatized)splash10-0002-0920000000-7a5478a80a1eb32d4b7a2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-EI-TOF (Non-derivatized)splash10-00di-9720000000-bc94d2ac28653eae38a42017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-MS (Non-derivatized)splash10-00di-1910000000-acee5ab7198285e8e50d2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-MS (Non-derivatized)splash10-001i-9500000000-33713ec79986844e54732017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-MS (Non-derivatized)splash10-0ufr-3950000000-776d858758510d8fe3b82017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-EI-TOF (Non-derivatized)splash10-0002-0920000000-af1ef43c6c84ceb25d5c2017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-MS (Non-derivatized) - 70eV, Positivesplash10-056r-9000000000-0f66197492d04223590a2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-MS (1 TMS) - 70eV, Positivesplash10-0a4i-9000000000-04cd2ffae30e797b9ce82017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 1-Aminocyclopropanecarboxylic acid GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid LC-ESI-QQ , negative-QTOFsplash10-0udi-1900000000-6ca112489bfda003824d2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid LC-ESI-QQ , negative-QTOFsplash10-0002-9000000000-bd4a1c4cd402aa288a762017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid LC-ESI-QTOF , negative-QTOFsplash10-0udi-1900000000-a1d7dde23e88cd41768a2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid , negative-QTOFsplash10-0udi-1900000000-efae844e876c90b68fef2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid LC-ESI-QTOF , positive-QTOFsplash10-0udi-0900000000-77275125d96326d211b22017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid , positive-QTOFsplash10-0pb9-9600000000-4cea9188f7383df64f1e2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 40V, Positive-QTOFsplash10-052o-9000000000-5861b86b1d52224d6d5a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 35V, Negative-QTOFsplash10-0udi-0900000000-c12f74f5ce8426ebe0e62021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 20V, Positive-QTOFsplash10-0a4i-9000000000-0cf1dc762da1017c4bf12021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 10V, Positive-QTOFsplash10-0a4i-9000000000-5427542157349cef74482021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 35V, Positive-QTOFsplash10-0zfr-9500000000-c324043aa89350c20bcf2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 10V, Positive-QTOFsplash10-0a4i-9000000000-9c0d99437bc01184ab132021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 40V, Positive-QTOFsplash10-0a4i-9000000000-1964bf27f6666638291d2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 20V, Positive-QTOFsplash10-0a4i-9000000000-7ee46f95fa62461bc5ee2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 10V, Negative-QTOFsplash10-0zfr-9100000000-ea0b2d7958408cd5c9132021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 10V, Positive-QTOFsplash10-0pb9-9300000000-244f710bfae169c961d02015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 20V, Positive-QTOFsplash10-0a4i-9000000000-5f673119a666f94f5dd52015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 40V, Positive-QTOFsplash10-0a4r-9000000000-2efefbe38e98daf65e222015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 10V, Negative-QTOFsplash10-0udi-2900000000-29f725068caae526a7b02015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 20V, Negative-QTOFsplash10-0udi-7900000000-02a1bc1d5a77ccf4ada22015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 40V, Negative-QTOFsplash10-0a4i-9000000000-22d9ef8cfddff91b4c312015-05-27Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 10V, Positive-QTOFsplash10-0a4i-9000000000-29f9d0ca1a1b141ffd592021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 20V, Positive-QTOFsplash10-0a4i-9000000000-4cffd7860609fa400e712021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 40V, Positive-QTOFsplash10-0a4i-9000000000-91482ac0f7314897ce882021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 1-Aminocyclopropanecarboxylic acid 10V, Negative-QTOFsplash10-0udi-0900000000-93fa1586f0ebdee30e202021-09-25Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB02085
Phenol Explorer Compound IDNot Available
FooDB IDFDB030242
KNApSAcK IDC00007566
Chemspider ID520
KEGG Compound IDC01234
BioCyc IDCPD-68
BiGG IDNot Available
Wikipedia Link1-Aminocyclopropane-1-carboxylic_acid
METLIN IDNot Available
PubChem Compound535
PDB IDNot Available
ChEBI ID18053
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .