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Record Information
Version4.0
StatusExpected but not Quantified
Creation Date2012-09-11 22:28:46 UTC
Update Date2019-07-23 06:23:18 UTC
HMDB IDHMDB0037238
Secondary Accession Numbers
  • HMDB37238
Metabolite Identification
Common NameHelium
DescriptionHelium, also known as 2HE or helio, belongs to the class of inorganic compounds known as homogeneous noble gases. These are inorganic non-metallic compounds in which the largest atom is a halogen atom. Helium is a second most abundant chemical element in the universe with symbol He and atomic number 2. It is also used as an analytical reagent in diagnostic/imaging tests to detect respiratory function of the patient. Helium is a drug which is used for use in patients who are not getting enough oxygen into their blood due to blockages in the lungs from pathological conditions or injuries. suggested potential benefit in upper airway obstruction, in severe asthma, and in exacerbations of copd/cold. helium may be used in place of carbon monoxide during laparoscopic surgeries as it lowers the risk of developing respiratory acidosis in selected patients. . Due to high thermal conductivity, may cause hypothermia in case of prolonged administration. Helium provides lung ventilation and prevents narrowing or collapse in respiratory units. Helium has a higher diffusion coefficient for carbon dioxide relative to oxygen thus promotes exhalation of trapped carbon dioxide. Helium is possibly neutral. Helium is an odorless tasting compound. Outside of the human body,. Its boiling and melting points are the lowest among all the elements. Cardioprotective effects against ischemia are mediated through early and late preconditioning by exposing the myocardial tissues to short ischemic episodes.
Structure
Data?1563862998
Synonyms
ValueSource
2HeChEBI
HeChEBI
HelioChEBI
(3He)HeliumHMDB
Atomic heliumHMDB
e939HMDB
Helium(0)HMDB
Helium, compressedHMDB
Helium, isotope OF mass 3HMDB
Helium-3HMDB
Helium-4HMDB
O-HeliumHMDB
p-HeliumHMDB
[He]HMDB
HeliumChEBI
Helium 4MeSH
Chemical FormulaHe
Average Molecular Weight4.0026
Monoisotopic Molecular Weight4.00260325
IUPAC Namehelium
Traditional Namehelium
CAS Registry Number7440-59-7
SMILES
[He]
InChI Identifier
InChI=1S/He
InChI KeySWQJXJOGLNCZEY-UHFFFAOYSA-N
Chemical Taxonomy
Description belongs to the class of inorganic compounds known as homogeneous noble gases. These are inorganic non-metallic compounds in which the largest atom is a halogen atom.
KingdomInorganic compounds
Super ClassHomogeneous non-metal compounds
ClassHomogeneous noble gases
Sub ClassNot Available
Direct ParentHomogeneous noble gases
Alternative ParentsNot Available
Substituents
  • Homogeneous noble gas
Molecular FrameworkNot Available
External Descriptors
Ontology
Disposition

Source:

Biological location:

Role

Industrial application:

Biological role:

Physical Properties
StateLiquid
Experimental Properties
PropertyValueReference
Melting Point-272.2 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP0.28Not Available
Predicted Properties
PropertyValueSource
logP0ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count0ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area0 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity0 m³·mol⁻¹ChemAxon
Polarizability1.78 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Spectra
Spectrum TypeDescriptionSplash KeyView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Positivesplash10-0a4i-9000000000-c9dea7a88bf1f195dda4Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Positivesplash10-0a4i-9000000000-c9dea7a88bf1f195dda4Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Positivesplash10-0a4i-9000000000-c9dea7a88bf1f195dda4Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 10V, Negativesplash10-0udi-9000000000-9dfa66cb33ce5f068d01Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 20V, Negativesplash10-0udi-9000000000-9dfa66cb33ce5f068d01Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 40V, Negativesplash10-0udi-9000000000-9dfa66cb33ce5f068d01Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB09155
Phenol Explorer Compound IDNot Available
FooDB IDFDB016248
KNApSAcK IDNot Available
Chemspider ID22423
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkHelium
METLIN IDNot Available
PubChem Compound23987
PDB IDNot Available
ChEBI ID30217
Food Biomarker OntologyNot Available
VMH IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Hart JL: Effects of hyperbaric helium-oxygen on the antipyretic actions of aspirin and acetaminophen in rats. Undersea Biomed Res. 1978 Mar;5(1):53-62. [PubMed:636074 ]
  2. Mouloudi E, Georgopoulos D: Treatment with aerosols in mechanically ventilated patients: is it worthwhile? Curr Opin Anaesthesiol. 2002 Feb;15(1):103-9. [PubMed:17019191 ]
  3. Koblin DD, Fang Z, Eger EI 2nd, Laster MJ, Gong D, Ionescu P, Halsey MJ, Trudell JR: Minimum alveolar concentrations of noble gases, nitrogen, and sulfur hexafluoride in rats: helium and neon as nonimmobilizers (nonanesthetics) Anesth Analg. 1998 Aug;87(2):419-24. [PubMed:9706943 ]
  4. (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .