Record Information |
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Version | 5.0 |
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Status | Expected but not Quantified |
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Creation Date | 2012-09-11 22:34:36 UTC |
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Update Date | 2022-03-07 02:55:17 UTC |
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HMDB ID | HMDB0037339 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | Luteolin 7-methyl ether |
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Description | Luteolin 7-methyl ether belongs to the class of organic compounds known as 7-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. Thus, luteolin 7-methyl ether is considered to be a flavonoid. Luteolin 7-methyl ether has been detected, but not quantified in, several different foods, such as herbs and spices, green tea, red tea, herbal tea, and black tea. This could make luteolin 7-methyl ether a potential biomarker for the consumption of these foods. Based on a literature review very few articles have been published on Luteolin 7-methyl ether. |
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Structure | COC1=CC(O)=C2C(=O)C=C(OC2=C1)C1=CC(O)=C(O)C=C1 InChI=1S/C16H12O6/c1-21-9-5-12(19)16-13(20)7-14(22-15(16)6-9)8-2-3-10(17)11(18)4-8/h2-7,17-19H,1H3 |
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Synonyms | Value | Source |
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2-(3,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one | HMDB | 2-(3,4-Dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-1-benzopyran-4-one, 9ci | HMDB | 5,3',4'-Trihydroxy-7-methoxyflavone | HMDB | 7-O-Methylluteolin | HMDB | Hydroxygenkwanin | MeSH |
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Chemical Formula | C16H12O6 |
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Average Molecular Weight | 300.2629 |
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Monoisotopic Molecular Weight | 300.063388116 |
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IUPAC Name | 2-(3,4-dihydroxyphenyl)-5-hydroxy-7-methoxy-4H-chromen-4-one |
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Traditional Name | luteolin 7-methyl ether |
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CAS Registry Number | 20243-59-8 |
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SMILES | COC1=CC(O)=C2C(=O)C=C(OC2=C1)C1=CC(O)=C(O)C=C1 |
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InChI Identifier | InChI=1S/C16H12O6/c1-21-9-5-12(19)16-13(20)7-14(22-15(16)6-9)8-2-3-10(17)11(18)4-8/h2-7,17-19H,1H3 |
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InChI Key | RRRSSAVLTCVNIQ-UHFFFAOYSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as 7-o-methylated flavonoids. These are flavonoids with methoxy groups attached to the C7 atom of the flavonoid backbone. |
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Kingdom | Organic compounds |
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Super Class | Phenylpropanoids and polyketides |
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Class | Flavonoids |
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Sub Class | O-methylated flavonoids |
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Direct Parent | 7-O-methylated flavonoids |
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Alternative Parents | |
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Substituents | - 7-methoxyflavonoid-skeleton
- Flavone
- 3'-hydroxyflavonoid
- 4'-hydroxyflavonoid
- 5-hydroxyflavonoid
- Hydroxyflavonoid
- Chromone
- Benzopyran
- 1-benzopyran
- Catechol
- Anisole
- Pyranone
- Phenol
- 1-hydroxy-2-unsubstituted benzenoid
- 1-hydroxy-4-unsubstituted benzenoid
- Alkyl aryl ether
- Benzenoid
- Pyran
- Monocyclic benzene moiety
- Heteroaromatic compound
- Vinylogous acid
- Oxacycle
- Organoheterocyclic compound
- Ether
- Organic oxide
- Organic oxygen compound
- Organooxygen compound
- Hydrocarbon derivative
- Aromatic heteropolycyclic compound
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Molecular Framework | Aromatic heteropolycyclic compounds |
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External Descriptors | |
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Ontology |
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Physiological effect | Not Available |
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Disposition | |
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Process | Not Available |
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Role | |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | Property | Value | Reference |
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Melting Point | 306 - 308 °C | Not Available | Boiling Point | Not Available | Not Available | Water Solubility | Not Available | Not Available | LogP | Not Available | Not Available |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatizedDerivatizedDerivative Name / Structure | SMILES | Kovats RI Value | Column Type | Reference |
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Luteolin 7-methyl ether,1TMS,isomer #1 | COC1=CC(O[Si](C)(C)C)=C2C(=O)C=C(C3=CC=C(O)C(O)=C3)OC2=C1 | 3293.4 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,1TMS,isomer #2 | COC1=CC(O)=C2C(=O)C=C(C3=CC=C(O)C(O[Si](C)(C)C)=C3)OC2=C1 | 3318.4 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,1TMS,isomer #3 | COC1=CC(O)=C2C(=O)C=C(C3=CC=C(O[Si](C)(C)C)C(O)=C3)OC2=C1 | 3354.6 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,2TMS,isomer #1 | COC1=CC(O[Si](C)(C)C)=C2C(=O)C=C(C3=CC=C(O[Si](C)(C)C)C(O)=C3)OC2=C1 | 3292.4 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,2TMS,isomer #2 | COC1=CC(O[Si](C)(C)C)=C2C(=O)C=C(C3=CC=C(O)C(O[Si](C)(C)C)=C3)OC2=C1 | 3269.0 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,2TMS,isomer #3 | COC1=CC(O)=C2C(=O)C=C(C3=CC=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C3)OC2=C1 | 3225.1 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,3TMS,isomer #1 | COC1=CC(O[Si](C)(C)C)=C2C(=O)C=C(C3=CC=C(O[Si](C)(C)C)C(O[Si](C)(C)C)=C3)OC2=C1 | 3154.3 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,1TBDMS,isomer #1 | COC1=CC(O[Si](C)(C)C(C)(C)C)=C2C(=O)C=C(C3=CC=C(O)C(O)=C3)OC2=C1 | 3577.6 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,1TBDMS,isomer #2 | COC1=CC(O)=C2C(=O)C=C(C3=CC=C(O)C(O[Si](C)(C)C(C)(C)C)=C3)OC2=C1 | 3578.1 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,1TBDMS,isomer #3 | COC1=CC(O)=C2C(=O)C=C(C3=CC=C(O[Si](C)(C)C(C)(C)C)C(O)=C3)OC2=C1 | 3611.1 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,2TBDMS,isomer #1 | COC1=CC(O[Si](C)(C)C(C)(C)C)=C2C(=O)C=C(C3=CC=C(O[Si](C)(C)C(C)(C)C)C(O)=C3)OC2=C1 | 3780.9 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,2TBDMS,isomer #2 | COC1=CC(O[Si](C)(C)C(C)(C)C)=C2C(=O)C=C(C3=CC=C(O)C(O[Si](C)(C)C(C)(C)C)=C3)OC2=C1 | 3749.2 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,2TBDMS,isomer #3 | COC1=CC(O)=C2C(=O)C=C(C3=CC=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C3)OC2=C1 | 3728.8 | Semi standard non polar | 33892256 | Luteolin 7-methyl ether,3TBDMS,isomer #1 | COC1=CC(O[Si](C)(C)C(C)(C)C)=C2C(=O)C=C(C3=CC=C(O[Si](C)(C)C(C)(C)C)C(O[Si](C)(C)C(C)(C)C)=C3)OC2=C1 | 3872.2 | Semi standard non polar | 33892256 |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - Luteolin 7-methyl ether GC-MS (Non-derivatized) - 70eV, Positive | splash10-0fl0-0590000000-fe91bcd17d90efeea961 | 2017-09-01 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Luteolin 7-methyl ether GC-MS (3 TMS) - 70eV, Positive | splash10-0ukc-2161960000-7bc9092b67b6d695ebc9 | 2017-10-06 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Luteolin 7-methyl ether GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum | Predicted GC-MS | Predicted GC-MS Spectrum - Luteolin 7-methyl ether GC-MS (Non-derivatized) - 70eV, Positive | Not Available | 2021-10-12 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Luteolin 7-methyl ether 10V, Positive-QTOF | splash10-0udi-0029000000-606b4cb8ba1d122f1377 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Luteolin 7-methyl ether 20V, Positive-QTOF | splash10-0udi-0189000000-3b7dd23ed7603c6a2382 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Luteolin 7-methyl ether 40V, Positive-QTOF | splash10-0zir-2490000000-f3e287f3d78aa8da00ad | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Luteolin 7-methyl ether 10V, Negative-QTOF | splash10-0002-0090000000-7809e9ae65d2112a1ffd | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Luteolin 7-methyl ether 20V, Negative-QTOF | splash10-0002-0090000000-afdd1a1cb4493a0415e5 | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Luteolin 7-methyl ether 40V, Negative-QTOF | splash10-00lr-2490000000-b0e365edc50ace3d87cf | 2016-08-03 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Luteolin 7-methyl ether 10V, Positive-QTOF | splash10-0udi-0009000000-545fc7c692e0abcd7966 | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Luteolin 7-methyl ether 20V, Positive-QTOF | splash10-0udi-0019000000-db7633ef115eab893fbb | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Luteolin 7-methyl ether 40V, Positive-QTOF | splash10-0a4r-0290000000-3fdbd8f853e60934e093 | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Luteolin 7-methyl ether 10V, Negative-QTOF | splash10-0002-0090000000-ea8480b3ca37fc485b0e | 2021-09-25 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - Luteolin 7-methyl ether 20V, Negative-QTOF | splash10-0532-0090000000-27686460288b02aa6d56 | 2021-09-25 | Wishart Lab | View Spectrum |
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