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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2013-07-19 22:32:29 UTC
Update Date2020-11-09 23:21:46 UTC
HMDB IDHMDB0061112
Secondary Accession Numbers
  • HMDB0062776
  • HMDB61112
  • HMDB62776
Metabolite Identification
Common Name3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid
Description3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid (CMPF) is also called 3-carboxy-4-methyl-5-propyl-2-furanpropanoic acid and 2-(2-carboxyethyl)-4-methyl-4-propylfuran-3-carboxylic acid. CMPF is significantly accumulated in the serum of chronic kidney disease patients and is considered to be a potent uremic toxin (PMID: 8734460 ) and identified as a uremic toxin according to the European Uremic Toxin Working Group (PMID: 22626821 ). There are several minor derivatives of CMPF that have been detected in serum and urine including 3-carboxy-4-methyl-5-pentyl-2-furanpropionic acid, 3-carboxy-4-methyl-5-ethyl-2-furanpropionic acid, and 3-carboxy-5-propyl-2-furanpropionic acid. CMPF was first detected in human urine in 1979 (PMID: 12388676 ) and it is believed to be formed from the consumption of fish, vegetables, and fruits (PMID: 19083276 ">19083276 ; PMID: 12388676 ). CMPF is a strong inhibitor of mitochondrial respiration and is associated with thyroid dysfunction (PMID: 19083276 ). CMPF also directly inhibits renal secretion of various drugs and endogenous organic acids by competitively inhibiting OAT3 transporters (PMID: 11967025 ). It is also thought to contribute to various neurological abnormalities because it inhibits the transport of organic acids at the blood-brain barrier (PMID: 12388676 ). 
Structure
Data?1563866147
Synonyms
ValueSource
CMPFChEBI
3-Carboxy-4-methyl-5-propyl-2-furanpropionateGenerator
3-Carboxy-4-methyl-5-propyl-2-furan-propanoateHMDB
U(3,3)HMDB
CMPFPAHMDB
3-Carboxy-4-methyl-5-propyl-2-furanpropanoic acidHMDB
Propylurofuranic acidHMDB
3-Carboxy-4-methyl-5-propyl-2-furanpropanoateHMDB
2-(2-Carboxyethyl)-4-methyl-4-propylfuran-3-carboxylic acidHMDB
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acidHMDB, ChEBI
Chemical FormulaC12H16O5
Average Molecular Weight240.2524
Monoisotopic Molecular Weight240.099773622
IUPAC Name2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid
Traditional Name2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid
CAS Registry Number86879-39-2
SMILES
CCCC1=C(C)C(C(O)=O)=C(CCC(O)=O)O1
InChI Identifier
InChI=1S/C12H16O5/c1-3-4-8-7(2)11(12(15)16)9(17-8)5-6-10(13)14/h3-6H2,1-2H3,(H,13,14)(H,15,16)
InChI KeyWMCQWXZMVIETAO-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as furanoid fatty acids. These are fatty acids containing a 5-alkylfuran-2-alkanoic acid.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassFatty Acyls
Sub ClassFatty acids and conjugates
Direct ParentFuranoid fatty acids
Alternative Parents
Substituents
  • Furanoid fatty acid
  • Furoic acid or derivatives
  • Furan-3-carboxylic acid
  • Furan-3-carboxylic acid or derivatives
  • Furoic acid
  • Dicarboxylic acid or derivatives
  • Furan
  • Heteroaromatic compound
  • Carboxylic acid derivative
  • Carboxylic acid
  • Oxacycle
  • Organoheterocyclic compound
  • Organic oxide
  • Organic oxygen compound
  • Hydrocarbon derivative
  • Organooxygen compound
  • Carbonyl group
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effect

Adverse health effect

Disposition

Biological location

Source

Route of exposure

Physical Properties
StateNot Available
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.22 g/LALOGPS
logP10(1.68) g/LALOGPS
logP10(2.3) g/LChemAxon
logS10(-3) g/LALOGPS
pKa (Strongest Acidic)3.87ChemAxon
pKa (Strongest Basic)-2.9ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area87.74 ŲChemAxon
Rotatable Bond Count6ChemAxon
Refractivity61.08 m³·mol⁻¹ChemAxon
Polarizability25.26 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+155.98831661259
DarkChem[M-H]-153.98531661259

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acidCCCC1=C(C)C(C(O)=O)=C(CCC(O)=O)O13011.4Standard polar33892256
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acidCCCC1=C(C)C(C(O)=O)=C(CCC(O)=O)O11789.3Standard non polar33892256
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acidCCCC1=C(C)C(C(O)=O)=C(CCC(O)=O)O11964.2Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid,1TMS,isomer #1CCCC1=C(C)C(C(=O)O[Si](C)(C)C)=C(CCC(=O)O)O12008.3Semi standard non polar33892256
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid,1TMS,isomer #2CCCC1=C(C)C(C(=O)O)=C(CCC(=O)O[Si](C)(C)C)O11976.6Semi standard non polar33892256
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid,2TMS,isomer #1CCCC1=C(C)C(C(=O)O[Si](C)(C)C)=C(CCC(=O)O[Si](C)(C)C)O11969.3Semi standard non polar33892256
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid,1TBDMS,isomer #1CCCC1=C(C)C(C(=O)O[Si](C)(C)C(C)(C)C)=C(CCC(=O)O)O12237.2Semi standard non polar33892256
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid,1TBDMS,isomer #2CCCC1=C(C)C(C(=O)O)=C(CCC(=O)O[Si](C)(C)C(C)(C)C)O12212.4Semi standard non polar33892256
3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid,2TBDMS,isomer #1CCCC1=C(C)C(C(=O)O[Si](C)(C)C(C)(C)C)=C(CCC(=O)O[Si](C)(C)C(C)(C)C)O12440.9Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid GC-MS (Non-derivatized) - 70eV, Positivesplash10-006x-2940000000-c178377899768707f7ef2017-09-20Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid GC-MS (2 TMS) - 70eV, Positivesplash10-00xr-9054000000-b2ed65a9650b6e0bed472017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid LC-ESI-IT , negative-QTOFsplash10-0002-0900000000-0bcba580e8c7fc7ff28d2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid Linear Ion Trap , negative-QTOFsplash10-0002-0900000000-d3d2687cc80d9e20e7a52017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid Linear Ion Trap , positive-QTOFsplash10-0002-0090000000-20d96334f84cb59f97b42017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid Linear Ion Trap , positive-QTOFsplash10-000i-0090000000-2e3fb6b1387a1189533e2017-09-14HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 10V, Positive-QTOFsplash10-006x-0590000000-b88aab92167a5dbc423e2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 20V, Positive-QTOFsplash10-002b-0920000000-f8bf7e8f3a2f5e6babdd2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 40V, Positive-QTOFsplash10-0udi-9700000000-8cde6db0deca358c01722016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 10V, Negative-QTOFsplash10-000j-0980000000-46874398810fc77285292016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 20V, Negative-QTOFsplash10-0002-1910000000-3c88cba9dade4657bc112016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 40V, Negative-QTOFsplash10-0pc0-6900000000-84761c36ced8150db9992016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 10V, Positive-QTOFsplash10-00dm-0890000000-464423a298584f86963e2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 20V, Positive-QTOFsplash10-004i-1930000000-39287c920da37a362af12021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 40V, Positive-QTOFsplash10-00dr-6900000000-a12a03c9a4db8d16d2812021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 10V, Negative-QTOFsplash10-002b-0910000000-057236b313c6ed05bb752021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 20V, Negative-QTOFsplash10-0udj-0900000000-e17797fad7625863d6b32021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 3-Carboxy-4-methyl-5-propyl-2-furanpropionic acid 40V, Negative-QTOFsplash10-054k-6900000000-f477479965ef2abe5fc42021-09-24Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane (predicted from logP)
Biospecimen Locations
  • Blood
  • Feces
  • Urine
Tissue Locations
  • Placenta
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified4.6 +/- 4.2 uMAdult (>18 years old)BothNormal details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Normal
details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Female
Normal
details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Female
Normal
details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Female
Normal
details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Female
Normal
details
BloodDetected and Quantified14.98 +/- 0.83 uMAdult (>18 years old)BothNormal details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified27.3 +/- 35.9 uMAdult (>18 years old)BothEnd-stage renal failure details
BloodDetected and Quantified36.63 +/- 20.81 uMAdult (>18 years old)Bothuremia details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal adenoma
details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal adenoma
details
BloodDetected and Quantified254.167 +/- 68.750 uMAdult (>18 years old)Both
Uremia
details
FecesDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothColorectal Cancer details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal adenoma
details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)Both
Colorectal adenoma
details
Associated Disorders and Diseases
Disease References
Uremia
  1. Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R, Argiles A: Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol. 2012 Jul;23(7):1258-70. doi: 10.1681/ASN.2011121175. Epub 2012 May 24. [PubMed:22626821 ]
  2. Vanholder R, De Smet R, Glorieux G, Argiles A, Baurmeister U, Brunet P, Clark W, Cohen G, De Deyn PP, Deppisch R, Descamps-Latscha B, Henle T, Jorres A, Lemke HD, Massy ZA, Passlick-Deetjen J, Rodriguez M, Stegmayr B, Stenvinkel P, Tetta C, Wanner C, Zidek W: Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int. 2003 May;63(5):1934-43. doi: 10.1046/j.1523-1755.2003.00924.x. [PubMed:12675874 ]
Colorectal cancer
  1. Brown DG, Rao S, Weir TL, O'Malia J, Bazan M, Brown RJ, Ryan EP: Metabolomics and metabolic pathway networks from human colorectal cancers, adjacent mucosa, and stool. Cancer Metab. 2016 Jun 6;4:11. doi: 10.1186/s40170-016-0151-y. eCollection 2016. [PubMed:27275383 ]
Associated OMIM IDs
DrugBank IDDB07517
Phenol Explorer Compound IDNot Available
FooDB IDFDB093609
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound123979
PDB IDNot Available
ChEBI ID41254
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Niwa T: Organic acids and the uremic syndrome: protein metabolite hypothesis in the progression of chronic renal failure. Semin Nephrol. 1996 May;16(3):167-82. [PubMed:8734460 ]
  2. Tsutsumi Y, Deguchi T, Takano M, Takadate A, Lindup WE, Otagiri M: Renal disposition of a furan dicarboxylic acid and other uremic toxins in the rat. J Pharmacol Exp Ther. 2002 Nov;303(2):880-7. [PubMed:12388676 ]
  3. Niwa T: Recent progress in the analysis of uremic toxins by mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Sep 1;877(25):2600-6. doi: 10.1016/j.jchromb.2008.11.032. Epub 2008 Nov 27. [PubMed:19083276 ]
  4. Deguchi T, Ohtsuki S, Otagiri M, Takanaga H, Asaba H, Mori S, Terasaki T: Major role of organic anion transporter 3 in the transport of indoxyl sulfate in the kidney. Kidney Int. 2002 May;61(5):1760-8. [PubMed:11967025 ]
  5. Duranton F, Cohen G, De Smet R, Rodriguez M, Jankowski J, Vanholder R, Argiles A: Normal and pathologic concentrations of uremic toxins. J Am Soc Nephrol. 2012 Jul;23(7):1258-70. doi: 10.1681/ASN.2011121175. Epub 2012 May 24. [PubMed:22626821 ]
  6. Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
  7. Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
  8. Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
  9. Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
  10. Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]
  11. Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.