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Showing metabocard for alpha-D-Glucose (HMDB0003345)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-08-12 19:09:59 UTC
Update Date2023-02-21 17:16:37 UTC
HMDB IDHMDB0003345
Secondary Accession Numbers
  • HMDB0061922
  • HMDB03345
  • HMDB61922
Metabolite Identification
Common Namealpha-D-Glucose
Description
Structure
Thumb
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0003345 (alpha-D-Glucose)

  Mrv1652309042000292D          

 12 12  0  0  1  0            999 V2000
   26.2084  -13.7915    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   23.3505  -14.6165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   23.3505  -16.2665    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   26.2084  -16.2665    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   24.7795  -17.0915    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   24.7795  -14.6165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   26.2084  -14.6165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.0650  -15.0290    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   25.4940  -15.0290    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   24.0650  -15.8540    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   25.4940  -15.8540    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   24.7795  -16.2665    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
  1  7  1  0  0  0  0
  8  2  1  1  0  0  0
 10  3  1  1  0  0  0
 11  4  1  1  0  0  0
 12  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 12  1  0  0  0  0
M  END
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3D MOL for HMDB0003345 (alpha-D-Glucose)

HMDB0003345
     RDKit          3D
alpha-D-Glucose
 24 24  0  0  0  0  0  0  0  0999 V2000
    3.0786    1.0102   -0.1496 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3839   -0.1679   -0.4483 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9364    0.0820   -0.1888 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3866    1.0961   -0.9360 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7875    1.5014   -0.3107 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.4769    2.0677    0.9374 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7868    0.4082   -0.1376 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.7503    0.8697    0.7861 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2078   -0.8548    0.4400 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1017   -1.8860    0.3813 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0762   -1.1429   -0.3480 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6897   -2.3038    0.0809 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0834    1.0737    0.8549 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7493   -0.9460    0.2207 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5790   -0.3764   -1.5285 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8452    0.3929    0.8915 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2568    2.3111   -0.9028 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2606    2.7350    0.8290 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2730    0.1623   -1.0852 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2548    1.3754    1.4769 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8763   -0.6239    1.4755 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8894   -2.6088   -0.2325 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2213   -1.2368   -1.4188 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8136   -2.9385   -0.6875 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  5  7  1  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 11  3  1  0
  1 13  1  0
  2 14  1  0
  2 15  1  0
  3 16  1  1
  5 17  1  6
  6 18  1  0
  7 19  1  6
  8 20  1  0
  9 21  1  1
 10 22  1  0
 11 23  1  6
 12 24  1  0
M  END
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3D SDF for HMDB0003345 (alpha-D-Glucose)

  Mrv1652309042000292D          

 12 12  0  0  1  0            999 V2000
   26.2084  -13.7915    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   23.3505  -14.6165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   23.3505  -16.2665    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   26.2084  -16.2665    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   24.7795  -17.0915    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   24.7795  -14.6165    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   26.2084  -14.6165    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   24.0650  -15.0290    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   25.4940  -15.0290    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   24.0650  -15.8540    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   25.4940  -15.8540    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
   24.7795  -16.2665    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
  1  7  1  0  0  0  0
  8  2  1  1  0  0  0
 10  3  1  1  0  0  0
 11  4  1  1  0  0  0
 12  5  1  6  0  0  0
  6  8  1  0  0  0  0
  6  9  1  0  0  0  0
  9  7  1  6  0  0  0
  8 10  1  0  0  0  0
  9 11  1  0  0  0  0
 10 12  1  0  0  0  0
 11 12  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0003345

> <DATABASE_NAME>
hmdb

> <SMILES>
OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O

> <INCHI_IDENTIFIER>
InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1

> <INCHI_KEY>
WQZGKKKJIJFFOK-DVKNGEFBSA-N

> <FORMULA>
C6H12O6

> <MOLECULAR_WEIGHT>
180.1559

> <EXACT_MASS>
180.063388116

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
24

> <JCHEM_AVERAGE_POLARIZABILITY>
16.092615901859798

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
5

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
(2S,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol

> <ALOGPS_LOGP>
-2.57

> <JCHEM_LOGP>
-2.932539218

> <ALOGPS_LOGS>
0.64

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
1

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
12.687538461190869

> <JCHEM_PKA_STRONGEST_ACIDIC>
11.298101552080594

> <JCHEM_PKA_STRONGEST_BASIC>
-2.9810792051782764

> <JCHEM_POLAR_SURFACE_AREA>
110.38000000000001

> <JCHEM_REFRACTIVITY>
35.923399999999994

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
7.82e+02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
α-glucose

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0003345 (alpha-D-Glucose)

HMDB0003345
     RDKit          3D
alpha-D-Glucose
 24 24  0  0  0  0  0  0  0  0999 V2000
    3.0786    1.0102   -0.1496 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.3839   -0.1679   -0.4483 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9364    0.0820   -0.1888 C   0  0  1  0  0  0  0  0  0  0  0  0
    0.3866    1.0961   -0.9360 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7875    1.5014   -0.3107 C   0  0  2  0  0  0  0  0  0  0  0  0
   -0.4769    2.0677    0.9374 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.7868    0.4082   -0.1376 C   0  0  2  0  0  0  0  0  0  0  0  0
   -2.7503    0.8697    0.7861 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2078   -0.8548    0.4400 C   0  0  1  0  0  0  0  0  0  0  0  0
   -2.1017   -1.8860    0.3813 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0762   -1.1429   -0.3480 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.6897   -2.3038    0.0809 O   0  0  0  0  0  0  0  0  0  0  0  0
    3.0834    1.0737    0.8549 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.7493   -0.9460    0.2207 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5790   -0.3764   -1.5285 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8452    0.3929    0.8915 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2568    2.3111   -0.9028 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.2606    2.7350    0.8290 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2730    0.1623   -1.0852 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2548    1.3754    1.4769 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8763   -0.6239    1.4755 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8894   -2.6088   -0.2325 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2213   -1.2368   -1.4188 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.8136   -2.9385   -0.6875 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  4  5  1  0
  5  6  1  0
  5  7  1  0
  7  8  1  0
  7  9  1  0
  9 10  1  0
  9 11  1  0
 11 12  1  0
 11  3  1  0
  1 13  1  0
  2 14  1  0
  2 15  1  0
  3 16  1  1
  5 17  1  6
  6 18  1  0
  7 19  1  6
  8 20  1  0
  9 21  1  1
 10 22  1  0
 11 23  1  6
 12 24  1  0
M  END
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PDB for HMDB0003345 (alpha-D-Glucose)

HEADER    PROTEIN                                 04-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   04-SEP-20         0                                  
HETATM    1  O   UNK     0      48.922 -25.744   0.000  0.00  0.00           O+0
HETATM    2  O   UNK     0      43.588 -27.284   0.000  0.00  0.00           O+0
HETATM    3  O   UNK     0      43.588 -30.364   0.000  0.00  0.00           O+0
HETATM    4  O   UNK     0      48.922 -30.364   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0      46.255 -31.904   0.000  0.00  0.00           O+0
HETATM    6  O   UNK     0      46.255 -27.284   0.000  0.00  0.00           O+0
HETATM    7  C   UNK     0      48.922 -27.284   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      44.921 -28.054   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      47.589 -28.054   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0      44.921 -29.594   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0      47.589 -29.594   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      46.255 -30.364   0.000  0.00  0.00           C+0
CONECT    1    7                                                            
CONECT    2    8                                                            
CONECT    3   10                                                            
CONECT    4   11                                                            
CONECT    5   12                                                            
CONECT    6    8    9                                                       
CONECT    7    1    9                                                       
CONECT    8    2    6   10                                                  
CONECT    9    6    7   11                                                  
CONECT   10    3    8   12                                                  
CONECT   11    4    9   12                                                  
CONECT   12    5   10   11                                                  
MASTER        0    0    0    0    0    0    0    0   12    0   24    0
END
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3D PDB for HMDB0003345 (alpha-D-Glucose)

COMPND    HMDB0003345
HETATM    1  O1  UNL     1       3.079   1.010  -0.150  1.00  0.00           O  
HETATM    2  C1  UNL     1       2.384  -0.168  -0.448  1.00  0.00           C  
HETATM    3  C2  UNL     1       0.936   0.082  -0.189  1.00  0.00           C  
HETATM    4  O2  UNL     1       0.387   1.096  -0.936  1.00  0.00           O  
HETATM    5  C3  UNL     1      -0.787   1.501  -0.311  1.00  0.00           C  
HETATM    6  O3  UNL     1      -0.477   2.068   0.937  1.00  0.00           O  
HETATM    7  C4  UNL     1      -1.787   0.408  -0.138  1.00  0.00           C  
HETATM    8  O4  UNL     1      -2.750   0.870   0.786  1.00  0.00           O  
HETATM    9  C5  UNL     1      -1.208  -0.855   0.440  1.00  0.00           C  
HETATM   10  O5  UNL     1      -2.102  -1.886   0.381  1.00  0.00           O  
HETATM   11  C6  UNL     1       0.076  -1.143  -0.348  1.00  0.00           C  
HETATM   12  O6  UNL     1       0.690  -2.304   0.081  1.00  0.00           O  
HETATM   13  H1  UNL     1       3.083   1.074   0.855  1.00  0.00           H  
HETATM   14  H2  UNL     1       2.749  -0.946   0.221  1.00  0.00           H  
HETATM   15  H3  UNL     1       2.579  -0.376  -1.528  1.00  0.00           H  
HETATM   16  H4  UNL     1       0.845   0.393   0.891  1.00  0.00           H  
HETATM   17  H5  UNL     1      -1.257   2.311  -0.903  1.00  0.00           H  
HETATM   18  H6  UNL     1       0.261   2.735   0.829  1.00  0.00           H  
HETATM   19  H7  UNL     1      -2.273   0.162  -1.085  1.00  0.00           H  
HETATM   20  H8  UNL     1      -2.255   1.375   1.477  1.00  0.00           H  
HETATM   21  H9  UNL     1      -0.876  -0.624   1.475  1.00  0.00           H  
HETATM   22  H10 UNL     1      -1.889  -2.609  -0.232  1.00  0.00           H  
HETATM   23  H11 UNL     1      -0.221  -1.237  -1.419  1.00  0.00           H  
HETATM   24  H12 UNL     1       0.814  -2.939  -0.688  1.00  0.00           H  
CONECT    1    2   13
CONECT    2    3   14   15
CONECT    3    4   11   16
CONECT    4    5
CONECT    5    6    7   17
CONECT    6   18
CONECT    7    8    9   19
CONECT    8   20
CONECT    9   10   11   21
CONECT   10   22
CONECT   11   12   23
CONECT   12   24
END
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SMILES for HMDB0003345 (alpha-D-Glucose)

OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
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INCHI for HMDB0003345 (alpha-D-Glucose)

InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
Chemical FormulaC6H12O6
Average Molecular Weight180.1559
Monoisotopic Molecular Weight180.063388116
IUPAC Name(2S,3R,4S,5S,6R)-6-(hydroxymethyl)oxane-2,3,4,5-tetrol
Traditional Nameα-glucose
CAS Registry Number492-62-6
SMILES
OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
InChI Identifier
InChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChI KeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as hexoses. These are monosaccharides in which the sugar unit is a is a six-carbon containing moeity.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentHexoses
Alternative Parents
Substituents
  • Hexose monosaccharide
  • Oxane
  • Secondary alcohol
  • Hemiacetal
  • Oxacycle
  • Organoheterocyclic compound
  • Polyol
  • Hydrocarbon derivative
  • Primary alcohol
  • Alcohol
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
Process
Naturally occurring process
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point146 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility500 mg/mL at 20 °CNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
  • Extracellular
  • Lysosome
  • Endoplasmic reticulum
  • Golgi apparatus
Biospecimen Locations
  • Blood
  • Breast Milk
  • Cerebrospinal Fluid (CSF)
  • Feces
  • Saliva
  • Sweat
  • Urine
Tissue Locations
  • Adipose Tissue
  • Adrenal Cortex
  • Adrenal Gland
  • Adrenal Medulla
  • Bladder
  • Brain
  • Epidermis
  • Eye Lens
  • Fibroblasts
  • Intestine
  • Kidney
  • Liver
  • Lung
  • Neuron
  • Ovary
  • Pancreas
  • Placenta
  • Prostate
  • Skeletal Muscle
  • Testis
Pathways
Normal Concentrations
Abnormal Concentrations
Associated Disorders and Diseases
Disease References
Glucagon deficiency
  1. Vidnes J, Oyasaeter S: Glucagon deficiency causing severe neonatal hypoglycemia in a patient with normal insulin secretion. Pediatr Res. 1977 Sep;11(9 Pt 1):943-9. [PubMed:904979 ]
Beckwith-Wiedemann Syndrome
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3-Hydroxy-3-methylglutaryl-CoA lyase deficiency
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Hyperinsulinemic hypoglycemia, familial, 1, HHF1
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Long-chain Fatty Acids, Defect in Transport of
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Carnitine transporter defect; primary systemic carnitine deficiency
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Fructose-1,6-diphosphatase deficiency
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Leigh's syndrome, subacute necrotizing encephalopathy, SNE
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Proprotein Convertase 1/3 Deficiency
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Diabetes and Deafness, Maternally Inherited
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3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency
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Primary hypomagnesemia
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Leptin Deficiency or Dysfunction
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21-Hydroxylase deficiency
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3-Hydroxyacyl-CoA dehydrogenase deficiency
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Carnitine palmitoyltransferase I deficiency
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Acute myelogenous leukemia
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Short-chain L-3-hydroxyacyl-CoA dehydrogenase deficiency
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Mitochondrial trifunctional protein deficiency
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Hypoglycemia, familial neonatal
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Hyperlipoproteinemia
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2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency
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Growth hormone deficiency
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Adrenal insufficiency, congenital, with 46,XY sex reversal, partial or complete
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Maturity onset diabetes of the young, type 2
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Schizophrenia
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Early preeclampsia
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Pregnancy
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  2. Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: First-trimester metabolomic detection of late-onset preeclampsia. Am J Obstet Gynecol. 2013 Jan;208(1):58.e1-7. doi: 10.1016/j.ajog.2012.11.003. Epub 2012 Nov 13. [PubMed:23159745 ]
  3. Bahado-Singh RO, Akolekar R, Mandal R, Dong E, Xia J, Kruger M, Wishart DS, Nicolaides K: Metabolomic analysis for first-trimester Down syndrome prediction. Am J Obstet Gynecol. 2013 May;208(5):371.e1-8. doi: 10.1016/j.ajog.2012.12.035. Epub 2013 Jan 8. [PubMed:23313728 ]
  4. Bahado-Singh RO, Akolekar R, Chelliah A, Mandal R, Dong E, Kruger M, Wishart DS, Nicolaides K: Metabolomic analysis for first-trimester trisomy 18 detection. Am J Obstet Gynecol. 2013 Jul;209(1):65.e1-9. doi: 10.1016/j.ajog.2013.03.028. Epub 2013 Mar 25. [PubMed:23535240 ]
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Late-onset preeclampsia
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Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency
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Infantile Liver Failure Syndrome 2
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Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration
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Donohue Syndrome
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Phosphoenolpyruvate Carboxykinase Deficiency 1, Cytosolic
  1. Santra S, Cameron JM, Shyr C, Zhang L, Drogemoller B, Ross CJ, Wasserman WW, Wevers RA, Rodenburg RJ, Gupte G, Preece MA, van Karnebeek CD: Cytosolic phosphoenolpyruvate carboxykinase deficiency presenting with acute liver failure following gastroenteritis. Mol Genet Metab. 2016 May;118(1):21-7. doi: 10.1016/j.ymgme.2016.03.001. Epub 2016 Mar 4. [PubMed:26971250 ]
  2. Vieira P, Cameron J, Rahikkala E, Keski-Filppula R, Zhang LH, Santra S, Matthews A, Myllynen P, Nuutinen M, Moilanen JS, Rodenburg RJ, Rolfs A, Uusimaa J, van Karnebeek CDM: Novel homozygous PCK1 mutation causing cytosolic phosphoenolpyruvate carboxykinase deficiency presenting as childhood hypoglycemia, an abnormal pattern of urine metabolites and liver dysfunction. Mol Genet Metab. 2017 Apr;120(4):337-341. doi: 10.1016/j.ymgme.2017.02.003. Epub 2017 Feb 6. [PubMed:28216384 ]
Sepsis
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Lipodystrophy
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Lipodystrophy, Congenital Generalized
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Partial lipodystrophy
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Familial partial lipodystrophy
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3-Methyl-crotonyl-glycinuria
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Addison's Disease
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Fanconi Bickel syndrome
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Wolcott-Rallison syndrome
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Alzheimer's disease
  1. Redjems-Bennani N, Jeandel C, Lefebvre E, Blain H, Vidailhet M, Gueant JL: Abnormal substrate levels that depend upon mitochondrial function in cerebrospinal fluid from Alzheimer patients. Gerontology. 1998;44(5):300-4. [PubMed:9693263 ]
Glucose transporter type 1 deficiency syndrome
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Irritable bowel syndrome
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Ulcerative colitis
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Gout
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Rheumatoid arthritis
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Colorectal cancer
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Diverticular disease
  1. Tursi A, Mastromarino P, Capobianco D, Elisei W, Miccheli A, Capuani G, Tomassini A, Campagna G, Picchio M, Giorgetti G, Fabiocchi F, Brandimarte G: Assessment of Fecal Microbiota and Fecal Metabolome in Symptomatic Uncomplicated Diverticular Disease of the Colon. J Clin Gastroenterol. 2016 Oct;50 Suppl 1:S9-S12. doi: 10.1097/MCG.0000000000000626. [PubMed:27622378 ]
Diabetes mellitus type 2
  1. Bales JR, Higham DP, Howe I, Nicholson JK, Sadler PJ: Use of high-resolution proton nuclear magnetic resonance spectroscopy for rapid multi-component analysis of urine. Clin Chem. 1984 Mar;30(3):426-32. [PubMed:6321058 ]
  2. Hoppel CL, Genuth SM: Urinary excretion of acetylcarnitine during human diabetic and fasting ketosis. Am J Physiol. 1982 Aug;243(2):E168-72. [PubMed:6810706 ]
  3. NA (1999). World Health Organisation Department of Noncommunicable Disease Surveillance (1999). "Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications". WHO.
Diabetes mellitus type 1
  1. Lorena Ivona ŞTEFAN, Alina NICOLESCU, Simona POPA, Maria MOŢA, Eugenia KOVACS and Calin DELEANU (2010). Lorena Ivona ŞTEFAN, Alina NICOLESCU, Simona POPA, Maria MOŢA, Eugenia KOVACS and Calin DELEANU. 1H-NMR URINE METABOLIC PROFILING IN TYPE 1 DIABETES MELLITUS. Rev. Roum. Chim., 2010, 55(11-12), 1033-1037 . Rev. Roum. Chim.
Eosinophilic esophagitis
  1. Slae, M., Huynh, H., Wishart, D.S. (2014). Analysis of 30 normal pediatric urine samples via NMR spectroscopy (unpublished work). NA.
Associated OMIM IDs
  • 130650 (Beckwith-Wiedemann Syndrome)
  • 246450 (3-Hydroxy-3-methylglutaryl-CoA lyase deficiency)
  • 256450 (Hyperinsulinemic hypoglycemia, familial, 1, HHF1)
  • 603376 (Long-chain Fatty Acids, Defect in Transport of)
  • 212140 (Carnitine transporter defect; primary systemic carnitine deficiency)
  • 229700 (Fructose-1,6-diphosphatase deficiency)
  • 256000 (Leigh's syndrome, subacute necrotizing encephalopathy, SNE)
  • 600955 (Proprotein Convertase 1/3 Deficiency)
  • 520000 (Diabetes and Deafness, Maternally Inherited)
  • 605911 (3-Hydroxy-3-Methylglutaryl-CoA Synthase Deficiency)
  • 248250 (Primary hypomagnesemia)
  • 614962 (Leptin Deficiency or Dysfunction)
  • 201910 (21-Hydroxylase deficiency)
  • 231530 (3-Hydroxyacyl-CoA dehydrogenase deficiency)
  • 255120 (Carnitine palmitoyltransferase I deficiency)
  • 602439 (Acute myelogenous leukemia)
  • 609015 (Mitochondrial trifunctional protein deficiency)
  • 240800 (Hypoglycemia, familial neonatal)
  • 238600 (Hyperlipoproteinemia)
  • 300438 (2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency)
  • 139250 (Growth hormone deficiency)
  • 613743 (Adrenal insufficiency, congenital, with 46,XY sex reversal, partial or complete)
  • 125851 (Maturity onset diabetes of the young, type 2)
  • 181500 (Schizophrenia)
  • 201810 (Adrenal hyperplasia, congenital, due to 3-beta-hydroxysteroid dehydrogenase 2 deficiency)
  • 616483 (Infantile Liver Failure Syndrome 2)
  • 616878 (Metabolic encephalomyopathic crises, recurrent, with rhabdomyolysis, cardiac arrhythmias, and neurodegeneration)
  • 246200 (Donohue Syndrome)
  • 261680 (Phosphoenolpyruvate Carboxykinase Deficiency 1, Cytosolic)
  • 608594 (Lipodystrophy, Congenital Generalized)
  • 608600 (Familial partial lipodystrophy)
  • 210200 (3-Methyl-crotonyl-glycinuria)
  • 240200 (Addison's Disease)
  • 227810 (Fanconi Bickel syndrome)
  • 226980 (Wolcott-Rallison syndrome)
  • 104300 (Alzheimer's disease)
  • 606777 (Glucose transporter type 1 deficiency syndrome)
  • 138900 (Gout)
  • 180300 (Rheumatoid arthritis)
  • 114500 (Colorectal cancer)
  • 125853 (Diabetes mellitus type 2)
  • 222100 (Diabetes mellitus type 1)
  • 610247 (Eosinophilic esophagitis)
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB011829
KNApSAcK IDC00001122
Chemspider ID71358
KEGG Compound IDC00267
BioCyc IDALPHA-GLUCOSE
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN ID6897
PubChem Compound79025
PDB IDNot Available
ChEBI ID17925
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceSimmons, Blake A.; Volponi, Joanne V.; Ingersoll, David; Walker, Andrew. Conversion of sucrose to b-D-glucose using three-stage immobilized enzyme process. U.S. (2007), 12pp.
Material Safety Data Sheet (MSDS)Not Available
General References

Only showing the first 10 proteins. There are 37 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. Aldose reductase
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.
Gene Name:
AKR1B1
Uniprot ID:
P15121
Molecular weight:
35853.125
Reactions
Sorbitol + NADP → alpha-D-Glucose + NADPH + Hydrogen Iondetails
Enzyme Details
2. Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
General function:
Involved in catalytic activity
Specific function:
Involved primarily in ATP hydrolysis at the plasma membrane. Plays a role in regulating pyrophosphate levels, and functions in bone mineralization and soft tissue calcification. In vitro, has a broad specificity, hydrolyzing other nucleoside 5' triphosphates such as GTP, CTP, TTP and UTP to their corresponding monophosphates with release of pyrophosphate and diadenosine polyphosphates, and also 3',5'-cAMP to AMP. May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling. Appears to modulate insulin sensitivity.
Gene Name:
ENPP1
Uniprot ID:
P22413
Molecular weight:
104923.58
Enzyme Details
3. Glucokinase
General function:
Involved in ATP binding
Specific function:
Catalyzes the initial step in utilization of glucose by the beta-cell and liver at physiological glucose concentration. Glucokinase has a high Km for glucose, and so it is effective only when glucose is abundant. The role of GCK is to provide G6P for the synthesis of glycogen. Pancreatic glucokinase plays an important role in modulating insulin secretion. Hepatic glucokinase helps to facilitate the uptake and conversion of glucose by acting as an insulin-sensitive determinant of hepatic glucose usage.
Gene Name:
GCK
Uniprot ID:
P35557
Molecular weight:
52191.07
Reactions
Adenosine triphosphate + alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Enzyme Details
4. Hexokinase-3
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK3
Uniprot ID:
P52790
Molecular weight:
99024.56
Reactions
Adenosine triphosphate + alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Enzyme Details
5. Hexokinase-2
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK2
Uniprot ID:
P52789
Molecular weight:
102379.06
Reactions
Adenosine triphosphate + alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Enzyme Details
6. Hexokinase-1
General function:
Involved in ATP binding
Specific function:
Not Available
Gene Name:
HK1
Uniprot ID:
P19367
Molecular weight:
102485.1
Reactions
Adenosine triphosphate + alpha-D-Glucose → ADP + Glucose 6-phosphatedetails
Enzyme Details
7. Sucrase-isomaltase, intestinal
General function:
Involved in catalytic activity
Specific function:
Plays an important role in the final stage of carbohydrate digestion. Isomaltase activity is specific for both alpha-1,4- and alpha-1,6-oligosaccharides.
Gene Name:
SI
Uniprot ID:
P14410
Molecular weight:
Not Available
Reactions
Sucrose + Water → D-Fructose + alpha-D-Glucosedetails
Isomaltose + Water → alpha-D-Glucose + D-Glucosedetails
Dextrin + Water → alpha-D-Glucose + Dextrindetails
Neohancoside D + Water → D-Fructose + alpha-D-Glucosedetails
+ Water → alpha-D-Glucose + details
Enzyme Details
8. GDH/6PGL endoplasmic bifunctional protein
General function:
Involved in 6-phosphogluconolactonase activity
Specific function:
Oxidizes glucose-6-phosphate and glucose, as well as other hexose-6-phosphates.
Gene Name:
H6PD
Uniprot ID:
O95479
Molecular weight:
88891.99
Enzyme Details
9. Lactase-phlorizin hydrolase
General function:
Involved in hydrolase activity, hydrolyzing O-glycosyl compounds
Specific function:
LPH splits lactose in the small intestine.
Gene Name:
LCT
Uniprot ID:
P09848
Molecular weight:
218584.77
Reactions
beta-Lactose + Water → alpha-D-Glucose + beta-D-Galactosedetails
Enzyme Details
10. Neutral alpha-glucosidase AB
General function:
Involved in catalytic activity
Specific function:
Cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins.
Gene Name:
GANAB
Uniprot ID:
Q14697
Molecular weight:
Not Available

Only showing the first 10 proteins. There are 37 proteins in total.

Show all enzymes and transporters