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HMDBP00656 (Argininosuccinate synthase) Metabolite Associations

Displaying all 10 metabolite protein links
HMDB ID Name CAS NumberStructureFormula Average Mass
Monoisotopic Mass 		References
HMDB0000045Adenosine monophosphate61-19-8ThumbC10H14N5O7P347.2212
347.063084339		Not Available
HMDB0000052Argininosuccinic acid2387-71-5ThumbC10H18N4O6290.2731
290.122634328		Not Available
HMDB0000191L-Aspartic acid56-84-8ThumbC4H7NO4133.1027
133.037507717
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Flam BR, Eichler DC, Solomonson LP: Endothelial nitric oxide production is tightly coupled to the citrulline-NO cycle. Nitric Oxide. 2007 Nov-Dec;17(3-4):115-21. Epub 2007 Aug 3. [PubMed:17869551 ]
  4. Ben-Yoseph Y, Mitchell DA: Detection of kinetically abnormal argininosuccinate synthase in neonatal citrullinemia by conversion of citrulline to arginine in intact fibroblasts. Clin Chim Acta. 1989 Aug 15;183(2):125-33. [PubMed:2791302 ]
  5. Shen LJ, Beloussow K, Shen WC: Accessibility of endothelial and inducible nitric oxide synthase to the intracellular citrulline-arginine regeneration pathway. Biochem Pharmacol. 2005 Jan 1;69(1):97-104. [PubMed:15588718 ]
HMDB0000250Pyrophosphate14000-31-8ThumbH4O7P2177.9751
177.943225506		Not Available
HMDB0000517L-Arginine74-79-3ThumbC6H14N4O2174.201
174.111675712		Not Available
HMDB0000538Adenosine triphosphate56-65-5ThumbC10H16N5O13P3507.181
506.995745159		Not Available
HMDB0000904Citrulline372-75-8ThumbC6H13N3O3175.1857
175.095691297
  1. Braissant O, Honegger P, Loup M, Iwase K, Takiguchi M, Bachmann C: Hyperammonemia: regulation of argininosuccinate synthetase and argininosuccinate lyase genes in aggregating cell cultures of fetal rat brain. Neurosci Lett. 1999 May 7;266(2):89-92. [PubMed:10353334 ]
  2. Braissant O, Gotoh T, Loup M, Mori M, Bachmann C: L-arginine uptake, the citrulline-NO cycle and arginase II in the rat brain: an in situ hybridization study. Brain Res Mol Brain Res. 1999 Jul 5;70(2):231-41. [PubMed:10407171 ]
  3. Keilhoff G, Reiser M, Stanarius A, Aoki E, Wolf G: Citrulline immunohistochemistry for demonstration of NOS activity in vivo and in vitro. Nitric Oxide. 2000 Aug;4(4):343-53. [PubMed:10944418 ]
  4. Zhang B, Cao GL, Domachowske J, Jackson MJ, Porasuphatana S, Rosen GM: Stable expression of varied levels of inducible nitric oxide synthase in primary cultures of endothelial cells. Anal Biochem. 2000 Nov 15;286(2):198-205. [PubMed:11067741 ]
  5. Zhang WY, Gotoh T, Oyadomari S, Mori M: Coinduction of inducible nitric oxide synthase and arginine recycling enzymes in cytokine-stimulated PC12 cells and high output production of nitric oxide. Brain Res Mol Brain Res. 2000 Nov 10;83(1-2):1-8. [PubMed:11072090 ]
HMDB0001429Phosphate14265-44-2ThumbH3O4P97.9952
97.976895096		Not Available
HMDB0012197Canavaninosuccinate56073-32-6ThumbC9H16N4O7292.2459
292.101898886		Not Available
HMDB0248323CarbamoylThumbCH2NO44.033
44.013638688		Not Available
Displaying all 10 metabolite protein links