Showing metabocard for Adenosine monophosphate (HMDB0000045)

General function:

Involved in hydrolase activity

Specific function:

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.

Gene Name:

NT5E

Uniprot ID:

P21589

Molecular weight:

57948.125

Reactions

General function:

Involved in nucleotide binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

Gene Name:

NT5C1B

Uniprot ID:

Q96P26

Molecular weight:

68803.055

Reactions

General function:

Involved in nucleotide binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.

Gene Name:

NT5C1A

Uniprot ID:

Q9BXI3

Molecular weight:

41020.145

Reactions

General function:

Involved in metal ion binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.

Gene Name:

NT5C

Uniprot ID:

Q8TCD5

Molecular weight:

Not Available

Reactions

General function:

Involved in ATP binding

Specific function:

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Gene Name:

DCK

Uniprot ID:

P27707

Molecular weight:

30518.315

Reactions

General function:

Involved in phosphatase activity

Specific function:

Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.

Gene Name:

NT5M

Uniprot ID:

Q9NPB1

Molecular weight:

Not Available

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Activates acetate so that it can be used for lipid synthesis or for energy generation.

Gene Name:

ACSS2

Uniprot ID:

Q9NR19

Molecular weight:

78579.11

Reactions

General function:

Involved in acetate-CoA ligase activity

Specific function:

Important for maintaining normal body temperature during fasting and for energy homeostasis. Essential for energy expenditure under ketogenic conditions (By similarity). Converts acetate to acetyl-CoA so that it can be used for oxidation through the tricarboxylic cycle to produce ATP and CO(2).

Gene Name:

ACSS1

Uniprot ID:

Q9NUB1

Molecular weight:

74625.88

Reactions

General function:

Involved in hydrolase activity

Specific function:

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Gene Name:

ENTPD1

Uniprot ID:

P49961

Molecular weight:

58706.0

Reactions

General function:

Involved in calcium ion binding

Specific function:

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.

Gene Name:

CANT1

Uniprot ID:

Q8WVQ1

Molecular weight:

44839.24