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Showing metabocard for Ethanolamine (HMDB0000149)

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IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological propertiesConcentrationsLinksReferencesenzymes (17) Show 17 proteinsXML
enzymes (17) Show 17 proteins
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-05-30 20:55:58 UTC
HMDB IDHMDB0000149
Secondary Accession Numbers
  • HMDB00149
  • HMDB0060149
  • HMDB0062693
  • HMDB60149
  • HMDB62693
Metabolite Identification
Common NameEthanolamine
DescriptionEthanolamine (MEA), also known as monoethanolamine, aminoethanol or glycinol, belongs to the class of organic compounds known as 1,2-aminoalcohols (or simply aminoalcohols). These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom. Ethanolamine is a colorless, viscous liquid with an odor reminiscent of ammonia. In pharmaceutical formulations, ethanolamine is used primarily for buffering or preparation of emulsions. Ethanolamine can also be used as pH regulator in cosmetics. Biologically, ethanolamine is an initial precursor for the biosynthesis of two primary phospholipid classes, phosphatidylcholine (PC) and phosphatidylethanolamine (PE). In this regard, ethanolamine is the second-most-abundant head group for phospholipids. Ethanolamine serves as a precursor for a variety of N-acylethanolamines (NAEs). These are molecules that modulate several animal and plant physiological processes such as seed germination, plant-pathogen interactions, chloroplast development and flowering (PMID: 30190434 ). Ethanolamine, when combined with arachidonic acid (C20H32O2; 20:4, ω-6), can also form the endocannabinoid anandamide. Ethanolamine can be converted to phosphoethanolamine via the enzyme known as ethanolamine kinase. the two substrates of this enzyme are ATP and ethanolamine, whereas its two products are ADP and O-phosphoethanolamine. In most plants ethanolamine is biosynthesized by decarboxylation of serine via a pyridoxal 5'-phosphate-dependent l-serine decarboxylase (SDC). Ethanolamine exists in all living species, ranging from bacteria to plants to humans. Ethanolamine has been detected, but not quantified in, several different foods, such as narrowleaf cattails, mung beans, blackcurrants, white cabbages, and bilberries.
Structure
Data?1676999673
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0000149 (Ethanolamine)


  Mrv1652309272007462D          

  4  3  0  0  0  0            999 V2000
   -1.5400    0.8143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2546    0.4017    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8256    0.4017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1110    0.8143    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  3  1  0  0  0  0
  3  4  1  0  0  0  0
  2  1  1  0  0  0  0
M  END
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3D MOL for HMDB0000149 (Ethanolamine)

HMDB0000149
     RDKit          3D
Ethanolamine
 11 10  0  0  0  0  0  0  0  0999 V2000
   -1.6782   -0.0379   -0.0289 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4017    0.3273    0.5561 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6952    0.0126   -0.4432 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9381    0.3515    0.0868 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8825   -1.0300    0.1281 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6138    0.1682   -1.0525 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1941   -0.2122    1.4986 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4275    1.4312    0.7001 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5238    0.5315   -1.3995 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6958   -1.1043   -0.5825 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3450   -0.4380    0.5368 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  1  5  1  0
  1  6  1  0
  2  7  1  0
  2  8  1  0
  3  9  1  0
  3 10  1  0
  4 11  1  0
M  END
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3D SDF for HMDB0000149 (Ethanolamine)


  Mrv1652309272007462D          

  4  3  0  0  0  0            999 V2000
   -1.5400    0.8143    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2546    0.4017    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.8256    0.4017    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1110    0.8143    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  3  1  0  0  0  0
  3  4  1  0  0  0  0
  2  1  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000149

> <DATABASE_NAME>
hmdb

> <SMILES>
NCCO

> <INCHI_IDENTIFIER>
InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2

> <INCHI_KEY>
HZAXFHJVJLSVMW-UHFFFAOYSA-N

> <FORMULA>
C2H7NO

> <MOLECULAR_WEIGHT>
61.0831

> <EXACT_MASS>
61.052763851

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
11

> <JCHEM_AVERAGE_POLARIZABILITY>
6.63098407374692

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
2

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
2-aminoethan-1-ol

> <ALOGPS_LOGP>
-1.53

> <JCHEM_LOGP>
-1.3155608773333334

> <ALOGPS_LOGS>
1.14

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
1

> <JCHEM_PKA_STRONGEST_ACIDIC>
15.61009842450122

> <JCHEM_PKA_STRONGEST_BASIC>
9.554610607853252

> <JCHEM_POLAR_SURFACE_AREA>
46.25

> <JCHEM_REFRACTIVITY>
16.2111

> <JCHEM_ROTATABLE_BOND_COUNT>
1

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
8.49e+02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
ethanolamine

> <JCHEM_VEBER_RULE>
0

$$$$
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3D-SDF for HMDB0000149 (Ethanolamine)

HMDB0000149
     RDKit          3D
Ethanolamine
 11 10  0  0  0  0  0  0  0  0999 V2000
   -1.6782   -0.0379   -0.0289 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4017    0.3273    0.5561 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6952    0.0126   -0.4432 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.9381    0.3515    0.0868 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.8825   -1.0300    0.1281 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6138    0.1682   -1.0525 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.1941   -0.2122    1.4986 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4275    1.4312    0.7001 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.5238    0.5315   -1.3995 H   0  0  0  0  0  0  0  0  0  0  0  0
    0.6958   -1.1043   -0.5825 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.3450   -0.4380    0.5368 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  3  4  1  0
  1  5  1  0
  1  6  1  0
  2  7  1  0
  2  8  1  0
  3  9  1  0
  3 10  1  0
  4 11  1  0
M  END
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PDB for HMDB0000149 (Ethanolamine)

HEADER    PROTEIN                                 27-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   27-SEP-20         0                                  
HETATM    1  C   UNK     0      -2.875   1.520   0.000  0.00  0.00           C+0
HETATM    2  N   UNK     0      -4.209   0.750   0.000  0.00  0.00           N+0
HETATM    3  C   UNK     0      -1.541   0.750   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0      -0.207   1.520   0.000  0.00  0.00           O+0
CONECT    1    3    2                                                       
CONECT    2    1                                                            
CONECT    3    1    4                                                       
CONECT    4    3                                                            
MASTER        0    0    0    0    0    0    0    0    4    0    6    0
END
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3D PDB for HMDB0000149 (Ethanolamine)

COMPND    HMDB0000149
HETATM    1  N1  UNL     1      -1.678  -0.038  -0.029  1.00  0.00           N  
HETATM    2  C1  UNL     1      -0.402   0.327   0.556  1.00  0.00           C  
HETATM    3  C2  UNL     1       0.695   0.013  -0.443  1.00  0.00           C  
HETATM    4  O1  UNL     1       1.938   0.352   0.087  1.00  0.00           O  
HETATM    5  H1  UNL     1      -1.882  -1.030   0.128  1.00  0.00           H  
HETATM    6  H2  UNL     1      -1.614   0.168  -1.052  1.00  0.00           H  
HETATM    7  H3  UNL     1      -0.194  -0.212   1.499  1.00  0.00           H  
HETATM    8  H4  UNL     1      -0.427   1.431   0.700  1.00  0.00           H  
HETATM    9  H5  UNL     1       0.524   0.532  -1.399  1.00  0.00           H  
HETATM   10  H6  UNL     1       0.696  -1.104  -0.582  1.00  0.00           H  
HETATM   11  H7  UNL     1       2.345  -0.438   0.537  1.00  0.00           H  
CONECT    1    2    5    6
CONECT    2    3    7    8
CONECT    3    4    9   10
CONECT    4   11
END
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SMILES for HMDB0000149 (Ethanolamine)

NCCO
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INCHI for HMDB0000149 (Ethanolamine)

InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
1-Amino-2-hydroxyethaneChEBI
2-Amino-1-ethanolChEBI
2-Amino-ethanolChEBI
2-Aminoethan-1-olChEBI
2-Aminoethyl alcoholChEBI
2-HydroxyethylamineChEBI
AethanolaminChEBI
AminoethanolChEBI
beta-AminoethanolChEBI
beta-Aminoethyl alcoholChEBI
beta-EthanolamineChEBI
beta-HydroxyethylamineChEBI
ColamineChEBI
ETAChEBI
GlycinolChEBI
HeaChEBI
MEAChEBI
MONOETHANOLAMINEChEBI
b-AminoethanolGenerator
Β-aminoethanolGenerator
b-Aminoethyl alcoholGenerator
Β-aminoethyl alcoholGenerator
b-EthanolamineGenerator
Β-ethanolamineGenerator
b-HydroxyethylamineGenerator
Β-hydroxyethylamineGenerator
2-AminoethanolHMDB
2-EthanolamineHMDB
2-HydroxyethanamineHMDB
Envision conditioner PDD 9020HMDB
EthylolamineHMDB
H-GlycinolHMDB
MonoaethanolaminHMDB
OlamineHMDB
2 AminoethanolHMDB
EthanolaminePhytoBank
KolaminPhytoBank
Chemical FormulaC2H7NO
Average Molecular Weight61.0831
Monoisotopic Molecular Weight61.052763851
IUPAC Name2-aminoethan-1-ol
Traditional Nameethanolamine
CAS Registry Number141-43-5
SMILES
NCCO
InChI Identifier
InChI=1S/C2H7NO/c3-1-2-4/h4H,1-3H2
InChI KeyHZAXFHJVJLSVMW-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 1,2-aminoalcohols. These are organic compounds containing an alkyl chain with an amine group bound to the C1 atom and an alcohol group bound to the C2 atom.
KingdomOrganic compounds
Super ClassOrganic nitrogen compounds
ClassOrganonitrogen compounds
Sub ClassAmines
Direct Parent1,2-aminoalcohols
Alternative Parents
Substituents
  • 1,2-aminoalcohol
  • Organic oxygen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Primary amine
  • Primary alcohol
  • Organooxygen compound
  • Primary aliphatic amine
  • Alcohol
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
Process
Naturally occurring process