Showing metabocard for Uracil (HMDB0000300)

General function:

Involved in electron carrier activity

Specific function:

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. Also involved the degradation of the chemotherapeutic drug 5-fluorouracil.

Gene Name:

DPYD

Uniprot ID:

Q12882

Molecular weight:

111400.32

Reactions

References

1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

General function:

Involved in purine-nucleoside phosphorylase activity

Specific function:

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.

Gene Name:

PNP

Uniprot ID:

P00491

Molecular weight:

32117.69

Reactions

General function:

Involved in transferase activity, transferring glycosyl groups

Specific function:

May have a role in maintaining the integrity of the blood vessels. Has growth promoting activity on endothelial cells, angiogenic activity in vivo and chemotactic activity on endothelial cells in vitro. Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Gene Name:

TYMP

Uniprot ID:

P19971

Molecular weight:

49954.965

Reactions

General function:

Involved in transferase activity, transferring pentosyl groups

Specific function:

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.

Gene Name:

UPP1

Uniprot ID:

Q16831

Molecular weight:

33934.005

Reactions

General function:

Involved in transferase activity, transferring pentosyl groups

Specific function:

Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.

Gene Name:

UPP2

Uniprot ID:

O95045

Molecular weight:

41601.795

Reactions

General function:

Involved in ATP binding

Specific function:

May contribute to UTP accumulation needed for blast transformation and proliferation.

Gene Name:

UCKL1

Uniprot ID:

Q9NWZ5

Molecular weight:

59465.77

References

1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

General function:

Involved in nucleoside metabolic process

Specific function:

Not Available

Gene Name:

UPRT

Uniprot ID:

Q96BW1

Molecular weight:

Not Available

Reactions

General function:

Involved in G-protein coupled receptor protein signaling pathway

Specific function:

Dual specificity receptor for uracil nucleotides and cysteinyl leukotrienes (CysLTs). Signals through G(i) and inhibition of adenylyl cyclase. May mediate brain damage by nucleotides and CysLTs following ischemia

Gene Name:

GPR17

Uniprot ID:

Q13304

Molecular weight:

40989.0