Showing metabocard for L-Leucine (HMDB0000687)

General function:

Involved in catalytic activity

Specific function:

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine.

Gene Name:

BCAT1

Uniprot ID:

P54687

Molecular weight:

38644.77

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the first reaction in the catabolism of the essential branched chain amino acids leucine, isoleucine, and valine. May also function as a transporter of branched chain alpha-keto acids.

Gene Name:

BCAT2

Uniprot ID:

O15382

Molecular weight:

33776.315

Reactions

General function:

Involved in nucleotide binding

Specific function:

Not Available

Gene Name:

LARS2

Uniprot ID:

Q15031

Molecular weight:

101975.43

Reactions

General function:

Involved in nucleotide binding

Specific function:

Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.

Gene Name:

LARS

Uniprot ID:

Q9P2J5

Molecular weight:

134465.155

Reactions

General function:

Involved in catalytic activity

Specific function:

Required for the function of light chain amino-acid transporters. Involved in sodium-independent, high-affinity transport of large neutral amino acids such as phenylalanine, tyrosine, leucine, arginine and tryptophan. Involved in guiding and targeting of LAT1 and LAT2 to the plasma membrane. When associated with SLC7A6 or SLC7A7 acts as an arginine/glutamine exchanger, following an antiport mechanism for amino acid transport, influencing arginine release in exchange for extracellular amino acids. Plays a role in nitric oxide synthesis in human umbilical vein endothelial cells (HUVECs) via transport of L-arginine. Required for normal and neoplastic cell growth. When associated with SLC7A5/LAT1, is also involved in the transport of L-DOPA across the blood-brain barrier, and that of thyroid hormones triiodothyronine (T3) and thyroxine (T4) across the cell membrane in tissues such as placenta. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. When associated with SLC7A5 or SLC7A8, involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L- nitrosocysteine (L-CNSO) across the transmembrane. Together with ICAM1, regulates the transport activity LAT2 in polarized intestinal cells, by generating and delivering intracellular signals. When associated with SLC7A5, plays an important role in transporting L-leucine from the circulating blood to the retina across the inner blood-retinal barrier

Gene Name:

SLC3A2

Uniprot ID:

P08195

Molecular weight:

67993.3

General function:

Involved in methyltransferase activity

Specific function:

Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha- leucine ester residues

Gene Name:

LCMT2

Uniprot ID:

O60294

Molecular weight:

75601.1

General function:

Involved in methyltransferase activity

Specific function:

Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues.

Gene Name:

LCMT1

Uniprot ID:

Q9UIC8

Molecular weight:

32171.66