Showing metabocard for (S)-Methylmalonic acid semialdehyde (HMDB0002217)

General function:

Involved in oxidoreductase activity

Specific function:

Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA.

Gene Name:

ALDH6A1

Uniprot ID:

Q02252

Molecular weight:

57839.31

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Not Available

Gene Name:

AOX1

Uniprot ID:

Q06278

Molecular weight:

147916.735

Reactions

General function:

Involved in 4-aminobutyrate transaminase activity

Specific function:

Catalyzes the conversion of gamma-aminobutyrate and L-beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine.

Gene Name:

ABAT

Uniprot ID:

P80404

Molecular weight:

56438.405

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Converts gamma-trimethylaminobutyraldehyde into gamma-butyrobetaine. Catalyzes the irreversible oxidation of a broad range of aldehydes to the corresponding acids in an NAD-dependent reaction.

Gene Name:

ALDH9A1

Uniprot ID:

P49189

Molecular weight:

56291.485

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Multifunctional enzyme mediating important protective effects. Metabolizes betaine aldehyde to betaine, an important cellular osmolyte and methyl donor. Protects cells from oxidative stress by metabolizing a number of lipid peroxidation-derived aldehydes. Involved in lysine catabolism.

Gene Name:

ALDH7A1

Uniprot ID:

P49419

Molecular weight:

58486.74

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).

Gene Name:

ALDH1A3

Uniprot ID:

P47895

Molecular weight:

56107.995

General function:

Involved in oxidoreductase activity

Specific function:

Not Available

Gene Name:

ALDH2

Uniprot ID:

P05091

Molecular weight:

56380.93

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid.

Gene Name:

ALDH3A2

Uniprot ID:

P51648

Molecular weight:

54847.36

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation.

Gene Name:

ALDH1B1

Uniprot ID:

P30837

Molecular weight:

57248.96

Reactions

General function:

Involved in oxidoreductase activity

Specific function:

Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/TRMT10C, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).

Gene Name:

HSD17B10

Uniprot ID:

Q99714

Molecular weight:

25983.695