Showing metabocard for Oxidized glutathione (HMDB0003337)

General function:

Involved in oxidoreductase activity

Specific function:

Maintains high levels of reduced glutathione in the cytosol.

Gene Name:

GSR

Uniprot ID:

P00390

Molecular weight:

56256.565

Reactions

General function:

Involved in antioxidant activity

Specific function:

Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.

Gene Name:

PRDX6

Uniprot ID:

P30041

Molecular weight:

25034.715

Reactions

General function:

Involved in proteolysis

Specific function:

Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.

Gene Name:

ANPEP

Uniprot ID:

P15144

Molecular weight:

Not Available

General function:

Involved in glutathione peroxidase activity

Specific function:

It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.

Gene Name:

GPX7

Uniprot ID:

Q96SL4

Molecular weight:

20995.88

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.

Gene Name:

GPX5

Uniprot ID:

O75715

Molecular weight:

25202.14

Reactions

General function:

Involved in glutathione transferase activity

Specific function:

Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.

Gene Name:

GSTO1

Uniprot ID:

P78417

Molecular weight:

27565.6

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

Not Available

Gene Name:

GPX6

Uniprot ID:

P59796

Molecular weight:

24970.46

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

Protects the hemoglobin in erythrocytes from oxidative breakdown.

Gene Name:

GPX1

Uniprot ID:

P07203

Molecular weight:

22087.94

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).

Gene Name:

GPX4

Uniprot ID:

P36969

Molecular weight:

25046.57

Reactions

General function:

Involved in glutathione peroxidase activity

Specific function:

Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.

Gene Name:

GPX3

Uniprot ID:

P22352

Molecular weight:

25552.185

Reactions