Hmdb loader
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-08-12 19:06:03 UTC
Update Date2021-10-13 04:41:16 UTC
HMDB IDHMDB0003337
Secondary Accession Numbers
  • HMDB03337
Metabolite Identification
Common NameOxidized glutathione
DescriptionOxidized glutathione, also known as glutathione disulfide or GSSG, belongs to the class of organic compounds known as peptides. Peptides are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by the formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another. In humans, oxidized glutathione is involved in the metabolic disorder called leukotriene C4 synthesis deficiency pathway. Outside of the human body, oxidized glutathione has been detected, but not quantified in several different foods, such as leeks, star anises, mamey sapotes, climbing beans, and common persimmons. Oxidized glutathione is a glutathione dimer formed by a disulfide bond between the cysteine sulfhydryl side chains during the course of being oxidized. Glutathione participates in leukotriene synthesis and is a cofactor for the enzyme glutathione peroxidase. It is also important as a hydrophilic molecule that is added to lipophilic toxins and waste in the liver during biotransformation before they can become part of the bile. Glutathione is also needed for the detoxification of methylglyoxal, a toxin produced as a by-product of metabolism. This detoxification reaction is carried out by the glyoxalase system. Glyoxalase I (EC 4.4.1.5) catalyzes the conversion of methylglyoxal and reduced glutathione into S-D-lactoyl-glutathione. Glyoxalase II (EC 3.1.2.6) catalyzes the hydrolysis of S-D-lactoyl-glutathione into glutathione and D-lactate.
Structure
Data?1588172424
Synonyms
ValueSource
Glutathione disulphideChEBI
GSSGChEBI
Oxidised glutathioneChEBI
OXIDIZED glutathione disulfideChEBI
OxiglutationeChEBI
GlutathioneKegg
Glutathione disulfideGenerator
OXIDIZED glutathione disulphideGenerator
Disulfide, glutathioneMeSH
Glutathione disulfide, ion(1-)MeSH
Glutathione, oxidizedMeSH
Oxidized glutathioneChEBI
Glutathione-S-S-glutathioneHMDB
Glutathione-SSGHMDB
Oxidized L-glutathioneHMDB
SelenoglutathioneHMDB
Chemical FormulaC20H32N6O12S2
Average Molecular Weight612.631
Monoisotopic Molecular Weight612.151961898
IUPAC Name(2S)-2-amino-4-{[(1R)-2-{[(2R)-2-[(4S)-4-amino-4-carboxybutanamido]-2-[(carboxymethyl)carbamoyl]ethyl]disulfanyl}-1-[(carboxymethyl)carbamoyl]ethyl]carbamoyl}butanoic acid
Traditional Nameglutathione disulfide
CAS Registry Number27025-41-8
SMILES
N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O
InChI Identifier
InChI=1S/C20H32N6O12S2/c21-9(19(35)36)1-3-13(27)25-11(17(33)23-5-15(29)30)7-39-40-8-12(18(34)24-6-16(31)32)26-14(28)4-2-10(22)20(37)38/h9-12H,1-8,21-22H2,(H,23,33)(H,24,34)(H,25,27)(H,26,28)(H,29,30)(H,31,32)(H,35,36)(H,37,38)/t9-,10-,11-,12-/m0/s1
InChI KeyYPZRWBKMTBYPTK-BJDJZHNGSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as peptides. Peptides are compounds containing an amide derived from two or more amino carboxylic acid molecules (the same or different) by formation of a covalent bond from the carbonyl carbon of one to the nitrogen atom of another.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentPeptides
Alternative Parents
Substituents
  • Alpha peptide
  • N-acyl-alpha-amino acid
  • N-acyl-alpha amino acid or derivatives
  • Tetracarboxylic acid or derivatives
  • Alpha-amino acid
  • Alpha-amino acid or derivatives
  • L-alpha-amino acid
  • Amino acid or derivatives
  • Amino acid
  • Dialkyldisulfide
  • Organic disulfide
  • Carboximidic acid
  • Carboximidic acid derivative
  • Carboxylic acid
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Sulfenyl compound
  • Amine
  • Hydrocarbon derivative
  • Organic oxide
  • Primary aliphatic amine
  • Organic oxygen compound
  • Organic nitrogen compound
  • Organonitrogen compound
  • Organooxygen compound
  • Organosulfur compound
  • Organopnictogen compound
  • Primary amine
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological locationSource
Process
Naturally occurring process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility300200 mg/L @ 25 °C (est)The Good Scents Company Information System
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.41 g/LALOGPS
logP-3.6ALOGPS
logP-10ChemAxon
logS-3.2ALOGPS
pKa (Strongest Acidic)1.44ChemAxon
pKa (Strongest Basic)9.61ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count14ChemAxon
Hydrogen Donor Count10ChemAxon
Polar Surface Area317.64 ŲChemAxon
Rotatable Bond Count21ChemAxon
Refractivity136.65 m³·mol⁻¹ChemAxon
Polarizability58.47 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+225.67430932474
DeepCCS[M-H]-223.77830932474
DeepCCS[M-2H]-257.01930932474
DeepCCS[M+Na]+231.48230932474
AllCCS[M+H]+226.732859911
AllCCS[M+H-H2O]+226.032859911
AllCCS[M+NH4]+227.332859911
AllCCS[M+Na]+227.532859911
AllCCS[M-H]-217.232859911
AllCCS[M+Na-2H]-218.732859911
AllCCS[M+HCOO]-220.632859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
Oxidized glutathioneN[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O5729.1Standard polar33892256
Oxidized glutathioneN[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O3955.8Standard non polar33892256
Oxidized glutathioneN[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(O)=O)C(=O)NCC(O)=O)C(=O)NCC(O)=O)C(O)=O5923.9Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Oxidized glutathione,1TMS,isomer #1C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O5194.5Semi standard non polar33892256
Oxidized glutathione,1TMS,isomer #2C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O5229.1Semi standard non polar33892256
Oxidized glutathione,1TMS,isomer #3C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O5390.4Semi standard non polar33892256
Oxidized glutathione,1TMS,isomer #4C[Si](C)(C)N(C(=O)CC[C@H](N)C(=O)O)[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O5253.0Semi standard non polar33892256
Oxidized glutathione,1TMS,isomer #5C[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O5298.7Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #1C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)NCC(=O)O5077.2Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #10C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O5098.2Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #11C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5258.5Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #12C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)O5258.5Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #13C[Si](C)(C)OC(=O)CN(C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C5136.5Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #14C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O5094.3Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #15C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O5143.8Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #16C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C5088.7Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #17C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N[Si](C)(C)C)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O5401.9Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #18C[Si](C)(C)N([C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O)[Si](C)(C)C5336.7Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #19C[Si](C)(C)N[C@@H](CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)[Si](C)(C)C)C(=O)O5245.7Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #2C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O5083.1Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #20C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5243.8Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #21C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5295.2Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #22C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)O5294.5Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #23C[Si](C)(C)N(C(=O)CC[C@H](N)C(=O)O)[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O5073.9Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #24C[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O5108.7Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #25C[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C5103.9Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #26C[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O5147.4Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #3C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C5083.0Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #4C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O[Si](C)(C)C5224.8Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #5C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O5236.8Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #6C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)[Si](C)(C)C5089.0Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #7C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O5091.7Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #8C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O5137.4Semi standard non polar33892256
Oxidized glutathione,2TMS,isomer #9C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C5137.1Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #1C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C5009.6Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #10C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)N(CC(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O5031.5Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #11C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C4986.5Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #12C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5151.0Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #13C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)O[Si](C)(C)C5138.5Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #14C[Si](C)(C)OC(=O)CN(C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)[Si](C)(C)C5013.8Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #15C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C4990.9Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #16C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C5032.0Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #17C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)[Si](C)(C)C4985.1Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #18C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N[Si](C)(C)C)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O5274.7Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #19C[Si](C)(C)OC(=O)[C@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)N([Si](C)(C)C)[Si](C)(C)C5235.2Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #2C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O[Si](C)(C)C5133.0Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #20C[Si](C)(C)N[C@@H](CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)[Si](C)(C)C)C(=O)O[Si](C)(C)C5114.5Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #21C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O[Si](C)(C)C5114.2Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #22C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O[Si](C)(C)C5162.1Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #23C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)O[Si](C)(C)C5161.6Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #24C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)NCC(=O)O5234.0Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #25C[Si](C)(C)N[C@@H](CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)NCC(=O)O)[Si](C)(C)C)C(=O)O5130.4Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #26C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5127.2Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #27C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5174.1Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #28C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)O5174.1Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #29C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N([C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)[Si](C)(C)C4971.5Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #3C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)[Si](C)(C)C)C(=O)NCC(=O)O4997.4Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #30C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)[Si](C)(C)C5013.2Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #31C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)[Si](C)(C)C5017.2Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #32C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@@H](C(=O)N(CC(=O)O)[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O5018.4Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #33C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)N(CC(=O)O)[Si](C)(C)C5014.2Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #34C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)N(CC(=O)O)[Si](C)(C)C5054.8Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #35C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)O5164.9Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #36C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O[Si](C)(C)C)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O5017.1Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #37C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@@H](C(=O)NCC(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O4992.4Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #38C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N[Si](C)(C)C)C(=O)O)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5297.8Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #39C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O5239.3Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #4C[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O5036.1Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #40C[Si](C)(C)N[C@@H](CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)[Si](C)(C)C)C(=O)O5138.0Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #41C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5128.8Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #42C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O[Si](C)(C)C)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5177.5Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #43C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)O5185.4Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #44C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C5239.2Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #45C[Si](C)(C)N[C@@H](CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O[Si](C)(C)C)[Si](C)(C)C)C(=O)O5130.4Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #46C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)O5136.6Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #47C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)O5185.1Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #48C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)N(CC(=O)O[Si](C)(C)C)[Si](C)(C)C)C(=O)O5177.2Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #49C[Si](C)(C)OC(=O)CN(C(=O)[C@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C4982.3Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #5C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O5013.9Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #50C[Si](C)(C)OC(=O)CN(C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C5024.8Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #51C[Si](C)(C)OC(=O)CN(C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)[Si](C)(C)C4994.1Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #52C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@@H](C(=O)N(CC(=O)O)[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O5012.0Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #53C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C4959.7Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #54C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C5003.1Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #55C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O5360.8Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #56C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N[Si](C)(C)C)C(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5257.9Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #57C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N[Si](C)(C)C)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5302.0Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #58C[Si](C)(C)N(C(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O5212.7Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #59C[Si](C)(C)N(C(=O)CC[C@H](N)C(=O)O)[C@@H](CSSC[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)NCC(=O)O5201.6Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #6C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O[Si](C)(C)C5138.5Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #60C[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O5243.6Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #61C[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)NC(=O)CC[C@@H](C(=O)O)N([Si](C)(C)C)[Si](C)(C)C5244.3Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #62C[Si](C)(C)N[C@@H](CCC(=O)N([C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)[Si](C)(C)C)C(=O)O5108.2Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #63C[Si](C)(C)N[C@@H](CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)[Si](C)(C)C)C(=O)O5143.8Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #64C[Si](C)(C)N[C@@H](CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)[Si](C)(C)C)C(=O)O5131.6Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #65C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@@H](C(=O)N(CC(=O)O)[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)O5133.0Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #66C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)O5144.5Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #67C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)N(CC(=O)O)[Si](C)(C)C)C(=O)O5184.2Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #68C[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C4990.1Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #69C[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@@H](C(=O)N(CC(=O)O)[Si](C)(C)C)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O5032.8Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #7C[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)C(=O)NCC(=O)O[Si](C)(C)C)C(=O)O5150.8Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #8C[Si](C)(C)OC(=O)CN(C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C5014.0Semi standard non polar33892256
Oxidized glutathione,3TMS,isomer #9C[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O[Si](C)(C)C)[Si](C)(C)C)NC(=O)CC[C@H](N)C(=O)O4989.6Semi standard non polar33892256
Oxidized glutathione,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O5458.0Semi standard non polar33892256
Oxidized glutathione,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O5497.4Semi standard non polar33892256
Oxidized glutathione,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O5624.1Semi standard non polar33892256
Oxidized glutathione,1TBDMS,isomer #4CC(C)(C)[Si](C)(C)N(C(=O)CC[C@H](N)C(=O)O)[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O5500.1Semi standard non polar33892256
Oxidized glutathione,1TBDMS,isomer #5CC(C)(C)[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O5539.9Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)NCC(=O)O)C(=O)NCC(=O)O5523.4Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O[Si](C)(C)C(C)(C)C)NC(=O)CC[C@H](N)C(=O)O5585.8Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #11CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O[Si](C)(C)C(C)(C)C)C(=O)NCC(=O)O)C(=O)O5688.4Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #12CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O[Si](C)(C)C(C)(C)C)C(=O)O5688.4Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #13CC(C)(C)[Si](C)(C)OC(=O)CN(C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C5590.2Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #14CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C)NC(=O)CC[C@H](N)C(=O)O5580.0Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #15CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C(C)(C)C)NC(=O)CC[C@H](N)C(=O)O5601.2Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #16CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C5574.5Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #17CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N[Si](C)(C)C(C)(C)C)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O5793.3Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #18CC(C)(C)[Si](C)(C)N([C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O)[Si](C)(C)C(C)(C)C5757.6Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #19CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)[Si](C)(C)C(C)(C)C)C(=O)O5680.9Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O5549.1Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #20CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C)C(=O)NCC(=O)O)C(=O)O5682.1Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #21CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C(C)(C)C)C(=O)NCC(=O)O)C(=O)O5699.5Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #22CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C(C)(C)C)C(=O)O5699.2Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #23CC(C)(C)[Si](C)(C)N(C(=O)CC[C@H](N)C(=O)O)[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C)C(=O)NCC(=O)O5557.2Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #24CC(C)(C)[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C)NC(=O)CC[C@H](N)C(=O)O5570.3Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #25CC(C)(C)[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C5555.4Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #26CC(C)(C)[Si](C)(C)N(CC(=O)O)C(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C(C)(C)C)NC(=O)CC[C@H](N)C(=O)O5586.5Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)CNC(=O)[C@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C(C)(C)C5549.2Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O[Si](C)(C)C(C)(C)C5638.1Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #5CC(C)(C)[Si](C)(C)N[C@@H](CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O[Si](C)(C)C(C)(C)C)C(=O)NCC(=O)O)C(=O)NCC(=O)O)C(=O)O5651.7Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N([C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)NCC(=O)O)[Si](C)(C)C(C)(C)C5545.6Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@@H](C(=O)NCC(=O)O)N(C(=O)CC[C@H](N)C(=O)O)[Si](C)(C)C(C)(C)C)C(=O)NCC(=O)O5547.4Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C(C)(C)C)C(=O)NCC(=O)O5569.4Semi standard non polar33892256
Oxidized glutathione,2TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC(=O)[C@@H](N)CCC(=O)N[C@@H](CSSC[C@H](NC(=O)CC[C@H](N)C(=O)O)C(=O)NCC(=O)O)C(=O)N(CC(=O)O)[Si](C)(C)C(C)(C)C5569.3Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Oxidized glutathione GC-EI-TOF (Non-derivatized)splash10-0a4i-0900000000-c8147955c6b355f0fc5c2017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Oxidized glutathione GC-EI-TOF (Non-derivatized)splash10-0a4i-0910000000-3e6195d480fbfe87b4492017-09-12HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_1_1) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_1_2) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_1_3) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_1_4) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_1_5) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_1) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_2) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_3) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_4) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_5) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_6) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_7) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_8) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_9) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_10) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_11) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_12) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_13) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_14) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_15) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_16) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_17) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Oxidized glutathione GC-MS (TMS_2_18) - 70eV, PositiveNot Available2021-10-16Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-ITFT , negative-QTOFsplash10-0uki-0290000000-04456f914411a2ecbe4f2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-ITFT , negative-QTOFsplash10-0a4i-0039210000-772eee67ad10a2d98fa72017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-QTOF , negative-QTOFsplash10-08fr-1957008000-f8812fd72d475ecd26932017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-QQ , positive-QTOFsplash10-03di-0000109000-65d563bcfc551b4a7abd2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-QQ , positive-QTOFsplash10-03di-0003309000-7555effd0b74737b9d2f2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-QQ , positive-QTOFsplash10-0a4i-0259201000-2cd328143ce713c285d92017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-QQ , positive-QTOFsplash10-05d0-0493000000-93bd088394049a484b9d2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-QQ , positive-QTOFsplash10-001r-0190000000-88b871b5a3f668f4b3a12017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-IT , positive-QTOFsplash10-0a59-0019811000-b24651cf6fc55de750b82017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-ITFT , positive-QTOFsplash10-053s-0495300000-69ab8e397b7a546ecd3f2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-ITFT , positive-QTOFsplash10-053r-0007920000-39da34018ceb610daa322017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-QTOF , positive-QTOFsplash10-03di-0000009000-9cde769e8905f413f7e32017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione LC-ESI-QTOF , positive-QTOFsplash10-03di-0000009000-4e3c9569882ab5507bf22017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione 35V, Positive-QTOFsplash10-0bu0-0269627000-563a5642bd80b3ade7e72021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione 30V, Positive-QTOFsplash10-03di-0000009000-5a6c9f84f565fed513042021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione 35V, Negative-QTOFsplash10-03di-0013009000-1867be9890f3ad9e87242021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione 10V, Negative-QTOFsplash10-03dl-0401019000-48fe7693149301cc4d472021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione 40V, Negative-QTOFsplash10-0a4l-8901000000-69744ab568a68f43a5da2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Oxidized glutathione 20V, Negative-QTOFsplash10-0btc-5739216000-b6e7a7ac62adb85e909e2021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxidized glutathione 10V, Positive-QTOFsplash10-0292-1000291000-9683d81eec1eab3f98832015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxidized glutathione 20V, Positive-QTOFsplash10-01u0-8214980000-1738ea6e3b4537936eee2015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxidized glutathione 40V, Positive-QTOFsplash10-057i-9534520000-7ef32e723a98599c32d72015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxidized glutathione 10V, Negative-QTOFsplash10-03di-0147096000-e516803ef5124daee1a72015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxidized glutathione 20V, Negative-QTOFsplash10-0a4l-2497151000-ef5ab8f9bbe20555f37c2015-09-15Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Oxidized glutathione 40V, Negative-QTOFsplash10-006y-9411230000-cc41719d1e717d2146432015-09-15Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Mitochondria
Biospecimen Locations
  • Blood
  • Cerebrospinal Fluid (CSF)
  • Saliva
  • Urine
Tissue Locations
  • Brain
  • Epidermis
  • Erythrocyte
  • Fibroblasts
  • Leukocyte
  • Liver
  • Pancreas
  • Placenta
  • Platelet
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified19.96 +/- 24.82 uMAdult (>18 years old)BothNormal details
BloodDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
BloodDetected and Quantified1.69 +/- 0.38 uMAdult (>18 years old)BothNormal details
Cerebrospinal Fluid (CSF)Detected and Quantified0.041 +/- 0.01 uMAdult (>18 years old)Not SpecifiedNormal details
SalivaDetected and Quantified0.88 +/- 0.43 uMAdult (>18 years old)FemaleNormal details
SalivaDetected and Quantified0.0156 +/- 0.0359 uMAdult (>18 years old)Female
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.207 +/- 0.264 uMAdult (>18 years old)Female
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.216 +/- 0.250 uMAdult (>18 years old)BothNormal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.249 +/- 0.397 uMAdult (>18 years old)BothNormal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.349 +/- 0.436 uMAdult (>18 years old)Not Specified
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.350 +/- 1.05 uMAdult (>18 years old)Female
Normal
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.350 +/- 1.05 uMAdult (>18 years old)Not Specified
Normal
    • Sugimoto et al. (...
details
UrineDetected but not QuantifiedNot QuantifiedAdult (>18 years old)BothNormal details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified27.94 +/- 23.19 uMAdult (>18 years old)BothSchizophrenia details
BloodDetected and Quantified1.98 +/- 0.41 uMAdult (>18 years old)BothCanavan disease details
Cerebrospinal Fluid (CSF)Detected and Quantified0.065 +/- 0.01 uMAdult (>18 years old)Not SpecifiedMultiple sclerosis details
Cerebrospinal Fluid (CSF)Detected and Quantified0.044 +/- 0.01 uMAdult (>18 years old)Not Specified
Multiple sclerosis
details
SalivaDetected and Quantified0.39 +/- 0.18 uMAdult (>18 years old)MaleAlzheimer's disease details
SalivaDetected and Quantified0.58 +/- 0.47 uMAdult (>18 years old)MaleFrontotemporal lobe dementia details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)MaleAttachment loss  details
SalivaDetected but not QuantifiedNot QuantifiedAdult (>18 years old)MalePeriodontal Probing Depth details
SalivaDetected and Quantified0.434 +/- 0.405 uMAdult (>18 years old)BothTemporomandibular joint disorder (TMD)
    • Sugimoto et al. (...
details
SalivaDetected and Quantified0.441 +/- 0.403 uMAdult (>18 years old)BothDental caries
    • Sugimoto et al. (...
details
SalivaDetected and Quantified2.91 +/- 4.90 uMAdult (>18 years old)BothLewy body disease details
Associated Disorders and Diseases
Disease References
Canavan disease
  1. Tavazzi B, Lazzarino G, Leone P, Amorini AM, Bellia F, Janson CG, Di Pietro V, Ceccarelli L, Donzelli S, Francis JS, Giardina B: Simultaneous high performance liquid chromatographic separation of purines, pyrimidines, N-acetylated amino acids, and dicarboxylic acids for the chemical diagnosis of inborn errors of metabolism. Clin Biochem. 2005 Nov;38(11):997-1008. Epub 2005 Sep 1. [PubMed:16139832 ]
Schizophrenia
  1. Ballesteros A, Summerfelt A, Du X, Jiang P, Chiappelli J, Tagamets M, O'Donnell P, Kochunov P, Hong LE: Electrophysiological intermediate biomarkers for oxidative stress in schizophrenia. Clin Neurophysiol. 2013 Nov;124(11):2209-15. doi: 10.1016/j.clinph.2013.05.021. Epub 2013 Jun 30. [PubMed:23823132 ]
Multiple sclerosis
  1. Calabrese V, Scapagnini G, Ravagna A, Bella R, Butterfield DA, Calvani M, Pennisi G, Giuffrida Stella AM: Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine. Neurochem Res. 2003 Sep;28(9):1321-8. [PubMed:12938853 ]
Alzheimer's disease
  1. Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
Frontotemporal dementia
  1. Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
Lewy body disease
  1. Tsuruoka M, Hara J, Hirayama A, Sugimoto M, Soga T, Shankle WR, Tomita M: Capillary electrophoresis-mass spectrometry-based metabolome analysis of serum and saliva from neurodegenerative dementia patients. Electrophoresis. 2013 Oct;34(19):2865-72. doi: 10.1002/elps.201300019. Epub 2013 Sep 6. [PubMed:23857558 ]
Temporomandibular joint disorder
  1. (). Sugimoto et al. (2013) Physiological and environmental parameters associated with mass spectrometry-based salivary metabolomic profiles. . .
Attachment loss
  1. Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26. [PubMed:31026179 ]
Periodontal Probing Depth
  1. Liebsch C, Pitchika V, Pink C, Samietz S, Kastenmuller G, Artati A, Suhre K, Adamski J, Nauck M, Volzke H, Friedrich N, Kocher T, Holtfreter B, Pietzner M: The Saliva Metabolome in Association to Oral Health Status. J Dent Res. 2019 Jun;98(6):642-651. doi: 10.1177/0022034519842853. Epub 2019 Apr 26. [PubMed:31026179 ]
Associated OMIM IDs
DrugBank IDDB03310
Phenol Explorer Compound IDNot Available
FooDB IDFDB023147
KNApSAcK IDNot Available
Chemspider ID58835
KEGG Compound IDC00127
BioCyc IDOXIDIZED-GLUTATHIONE
BiGG IDNot Available
Wikipedia LinkGlutathione disulfide
METLIN IDNot Available
PubChem Compound65359
PDB IDNot Available
ChEBI ID17858
Food Biomarker OntologyNot Available
VMH IDGTHOX
MarkerDB IDMDB00000421
Good Scents IDrw1736991
References
Synthesis ReferenceSaito, Susumu; Nishijima, Kunihide; Kataoka, Katsuyuki; Aoyanagi, Yoshinori; Fukuda, Yoji; Ito, Homare. Manufacture of oxidized glutathione from reduced glutathione with ascorbic acid and ascorbate oxidase. Jpn. Kokai Tokkyo Koho (1995), 4 pp.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Kondo T, Ohtsuka Y, Shimada M, Kawakami Y, Hiyoshi Y, Tsuji Y, Fujii H, Miwa S: Erythrocyte-oxidized glutathione transport in pyrimidine 5'-nucleotidase deficiency. Am J Hematol. 1987 Sep;26(1):37-45. [PubMed:2888306 ]
  2. Calabrese V, Scapagnini G, Ravagna A, Bella R, Butterfield DA, Calvani M, Pennisi G, Giuffrida Stella AM: Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: evidence for a protective role of acetylcarnitine. Neurochem Res. 2003 Sep;28(9):1321-8. [PubMed:12938853 ]
  3. Tauler P, Sureda A, Cases N, Aguilo A, Rodriguez-Marroyo JA, Villa G, Tur JA, Pons A: Increased lymphocyte antioxidant defences in response to exhaustive exercise do not prevent oxidative damage. J Nutr Biochem. 2006 Oct;17(10):665-71. Epub 2005 Nov 28. [PubMed:16481153 ]
  4. Slivka A, Spina MB, Cohen G: Reduced and oxidized glutathione in human and monkey brain. Neurosci Lett. 1987 Feb 10;74(1):112-8. [PubMed:3561870 ]
  5. Aukrust P, Svardal AM, Muller F, Lunden B, Berge RK, Ueland PM, Froland SS: Increased levels of oxidized glutathione in CD4+ lymphocytes associated with disturbed intracellular redox balance in human immunodeficiency virus type 1 infection. Blood. 1995 Jul 1;86(1):258-67. [PubMed:7795231 ]
  6. Sakhi AK, Russnes KM, Smeland S, Blomhoff R, Gundersen TE: Simultaneous quantification of reduced and oxidized glutathione in plasma using a two-dimensional chromatographic system with parallel porous graphitized carbon columns coupled with fluorescence and coulometric electrochemical detection. J Chromatogr A. 2006 Feb 3;1104(1-2):179-89. [PubMed:16376913 ]
  7. Glazyrin AL, Kolesnikov SI, Safronov AYu: Histochemical localization of oxidized glutathione-catalysing enzymes in human term placenta. Histochem J. 1993 Jan;25(1):45-50. [PubMed:8432663 ]
  8. Carru C, Zinellu A, Pes GM, Marongiu G, Tadolini B, Deiana L: Ultrarapid capillary electrophoresis method for the determination of reduced and oxidized glutathione in red blood cells. Electrophoresis. 2002 Jun;23(11):1716-21. [PubMed:12179993 ]
  9. Tohgi H, Abe T, Saheki M, Hamato F, Sasaki K, Takahashi S: Reduced and oxidized forms of glutathione and alpha-tocopherol in the cerebrospinal fluid of parkinsonian patients: comparison between before and after L-dopa treatment. Neurosci Lett. 1995 Jan 16;184(1):21-4. [PubMed:7739798 ]
  10. Yoshida T: Determination of reduced and oxidized glutathione in erythrocytes by high-performance liquid chromatography with ultraviolet absorbance detection. J Chromatogr B Biomed Appl. 1996 Apr 12;678(2):157-64. [PubMed:8738017 ]
  11. Sofic E, Lange KW, Jellinger K, Riederer P: Reduced and oxidized glutathione in the substantia nigra of patients with Parkinson's disease. Neurosci Lett. 1992 Aug 17;142(2):128-30. [PubMed:1454205 ]
  12. Muda P, Kampus P, Zilmer M, Zilmer K, Kairane C, Ristimae T, Fischer K, Teesalu R: Homocysteine and red blood cell glutathione as indices for middle-aged untreated essential hypertension patients. J Hypertens. 2003 Dec;21(12):2329-33. [PubMed:14654754 ]
  13. Satoh T, Yoshioka Y: Contribution of reduced and oxidized glutathione to signals detected by magnetic resonance spectroscopy as indicators of local brain redox state. Neurosci Res. 2006 May;55(1):34-9. Epub 2006 Feb 24. [PubMed:16503064 ]
  14. Srivastava SK, Beutler E: Oxidized glutathione levels in erythrocytes of glucose-6-phosphate-dehydrogenase-deficient subjects. Lancet. 1968 Jul 6;2(7558):23-4. [PubMed:4172687 ]
  15. Board P, Nishida T, Gatmaitan Z, Che M, Arias IM: Erythrocyte membrane transport of glutathione conjugates and oxidized glutathione in the Dubin-Johnson syndrome and in rats with hereditary hyperbilirubinemia. Hepatology. 1992 Apr;15(4):722-5. [PubMed:1551648 ]
  16. Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Only showing the first 10 proteins. There are 14 proteins in total.

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
Maintains high levels of reduced glutathione in the cytosol.
Gene Name:
GSR
Uniprot ID:
P00390
Molecular weight:
56256.565
Reactions
Glutathione + NADP → Oxidized glutathione + NADPHdetails
Glutathione + NAD → Oxidized glutathione + NADH + Hydrogen Iondetails
Glutathione + NADP → Oxidized glutathione + NADPH + Hydrogen Iondetails
General function:
Involved in antioxidant activity
Specific function:
Involved in redox regulation of the cell. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. May play a role in the regulation of phospholipid turnover as well as in protection against oxidative injury.
Gene Name:
PRDX6
Uniprot ID:
P30041
Molecular weight:
25034.715
Reactions
Glutathione + Hydrogen peroxide → Oxidized glutathione + Waterdetails
General function:
Involved in proteolysis
Specific function:
Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.
Gene Name:
ANPEP
Uniprot ID:
P15144
Molecular weight:
Not Available
General function:
Involved in glutathione peroxidase activity
Specific function:
It protects esophageal epithelia from hydrogen peroxide-induced oxidative stress. It suppresses acidic bile acid-induced reactive oxigen species (ROS) and protects against oxidative DNA damage and double-strand breaks.
Gene Name:
GPX7
Uniprot ID:
Q96SL4
Molecular weight:
20995.88
Reactions
Glutathione + Hydrogen peroxide → Oxidized glutathione + Waterdetails
Glutathione + 5(S)-Hydroperoxyeicosatetraenoic acid → Oxidized glutathione + 5-HETE + Waterdetails
Glutathione + 15(S)-HPETE → Oxidized glutathione + 15-HETE + Waterdetails
General function:
Involved in glutathione peroxidase activity
Specific function:
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. May constitute a glutathione peroxidase-like protective system against peroxide damage in sperm membrane lipids.
Gene Name:
GPX5
Uniprot ID:
O75715
Molecular weight:
25202.14
Reactions
Glutathione + Hydrogen peroxide → Oxidized glutathione + Waterdetails
Glutathione + 5(S)-Hydroperoxyeicosatetraenoic acid → Oxidized glutathione + 5-HETE + Waterdetails
Glutathione + 15(S)-HPETE → Oxidized glutathione + 15-HETE + Waterdetails
General function:
Involved in glutathione transferase activity
Specific function:
Exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities. Has S-(phenacyl)glutathione reductase activity. Has also glutathione S-transferase activity. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA) and dimethylarsonic acid.
Gene Name:
GSTO1
Uniprot ID:
P78417
Molecular weight:
27565.6
Reactions
Glutathione + Dehydroascorbic acid → Oxidized glutathione + Ascorbic aciddetails
Methylarsonate + Glutathione → Methylarsonite + Oxidized glutathione + Waterdetails
General function:
Involved in glutathione peroxidase activity
Specific function:
Not Available
Gene Name:
GPX6
Uniprot ID:
P59796
Molecular weight:
24970.46
Reactions
Glutathione + Hydrogen peroxide → Oxidized glutathione + Waterdetails
Glutathione + 5(S)-Hydroperoxyeicosatetraenoic acid → Oxidized glutathione + 5-HETE + Waterdetails
Glutathione + 15(S)-HPETE → Oxidized glutathione + 15-HETE + Waterdetails
General function:
Involved in glutathione peroxidase activity
Specific function:
Protects the hemoglobin in erythrocytes from oxidative breakdown.
Gene Name:
GPX1
Uniprot ID:
P07203
Molecular weight:
22087.94
Reactions
Glutathione + Hydrogen peroxide → Oxidized glutathione + Waterdetails
Glutathione + 5(S)-Hydroperoxyeicosatetraenoic acid → Oxidized glutathione + 5-HETE + Waterdetails
Glutathione + 15(S)-HPETE → Oxidized glutathione + 15-HETE + Waterdetails
General function:
Involved in glutathione peroxidase activity
Specific function:
Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage (By similarity).
Gene Name:
GPX4
Uniprot ID:
P36969
Molecular weight:
25046.57
Reactions
Glutathione + a lipid hydroperoxide → Oxidized glutathione + lipid + Waterdetails
Lipid hydroperoxide + Glutathione → Lipid + Oxidized glutathione + Waterdetails
General function:
Involved in glutathione peroxidase activity
Specific function:
Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione.
Gene Name:
GPX3
Uniprot ID:
P22352
Molecular weight:
25552.185
Reactions
Glutathione + Hydrogen peroxide → Oxidized glutathione + Waterdetails
Glutathione + 5(S)-Hydroperoxyeicosatetraenoic acid → Oxidized glutathione + 5-HETE + Waterdetails
Glutathione + 15(S)-HPETE → Oxidized glutathione + 15-HETE + Waterdetails

Only showing the first 10 proteins. There are 14 proteins in total.