Record Information |
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Version | 5.0 |
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Status | Predicted |
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Creation Date | 2007-09-05 14:38:35 UTC |
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Update Date | 2023-07-07 22:43:02 UTC |
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HMDB ID | HMDB0006725 |
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Secondary Accession Numbers | |
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Metabolite Identification |
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Common Name | CE(14:0) |
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Description | CE(14:0) is a cholesterol fatty acid ester or simply a cholesterol ester (CE). Cholesterol esters are cholesterol molecules with long-chain fatty acids linked to the hydroxyl group. They are much less polar than free cholesterol and appear to be the preferred form for transport in plasma and for storage. Cholesterol esters do not contribute to membranes but are packed into intracellular lipid particles or lipoprotein particles. Because of the mechanism of synthesis, plasma cholesterol esters tend to contain relatively high proportions of C18 fatty acids. Cholesterol esters are major constituents of the adrenal glands and they also accumulate in the fatty lesions of atherosclerotic plaques. Cholesterol esters are also major constituents of the lipoprotein particles carried in blood (HDL, LDL, VLDL). The cholesterol esters in high-density lipoproteins (HDL) are synthesized largely by transfer of fatty acids to cholesterol from position sn-2 (or C-2) of phosphatidylcholine catalyzed by the enzyme lecithin cholesterol acyl transferase (LCAT). The enzyme also promotes the transfer of cholesterol from cells to HDL. As cholesterol esters accumulate in the lipoprotein core, cholesterol is removed from its surface thus promoting the flow of cholesterol from cell membranes into HDL. This in turn leads to morphological changes in HDL, which grow and become spherical. Subsequently, cholesterol esters are transferred to the other lipoprotein fractions LDL and VLDL, a reaction catalyzed by cholesteryl ester transfer protein. Another enzyme, acyl-CoA:cholesterol acyltransferase (ACAT) synthesizes cholesterol esters from CoA esters of fatty acids and cholesterol. Cholesterol ester hydrolases liberate cholesterol and free fatty acids when required for membrane and lipoprotein formation, and they also provide cholesterol for hormone synthesis in adrenal cells. |
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Structure | [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)OC(=O)CCCCCCCCCCCCC)[C@H](C)CCCC(C)C InChI=1S/C41H72O2/c1-7-8-9-10-11-12-13-14-15-16-17-21-39(42)43-34-26-28-40(5)33(30-34)22-23-35-37-25-24-36(32(4)20-18-19-31(2)3)41(37,6)29-27-38(35)40/h22,31-32,34-38H,7-21,23-30H2,1-6H3/t32-,34+,35+,36-,37+,38+,40+,41-/m1/s1 |
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Synonyms | Value | Source |
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1-Myristoyl-cholesterol | ChEBI | CE(14:0/0:0) | ChEBI | Cholesterol 1-tetradecanoic acid | ChEBI | Cholesterol ester(14:0) | ChEBI | Cholesterol ester(14:0/0:0) | ChEBI | Cholesteryl tetradecanoate | ChEBI | Cholesterol 1-tetradecanoate | Generator | Cholesteryl tetradecanoic acid | Generator | Cholesteryl myristate | MeSH | CE(14:0) | Lipid Annotator, ChEBI | 14:0 cholesterol ester | Lipid Annotator, HMDB | cholesterol 1-myristoic acid | Lipid Annotator, HMDB | cholesteryl 1-myristoic acid | Lipid Annotator, HMDB | cholesteryl 1-tetradecanoic acid | Lipid Annotator, HMDB | cholesterol 1-myristoate | Lipid Annotator, HMDB | cholesteryl 1-tetradecanoate | Lipid Annotator, HMDB | cholesteryl 1-myristoate | Lipid Annotator, HMDB | 1-tetradecanoyl-cholesterol | Lipid Annotator, HMDB | Cholest-5-en-3-ol (3beta)-tetradecanoate | HMDB | Cholest-5-en-3-ol (3beta)-tetradecanoic acid | HMDB | Cholest-5-en-3beta-yl myristate | HMDB | Cholest-5-en-3beta-yl tetradecanoate | HMDB | Cholest-5-en-3beta-yl tetradecanoic acid | HMDB | Cholesterol myristate | HMDB | Cholestryl myristate | HMDB | Cholestryl myristic acid | HMDB |
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Chemical Formula | C41H72O2 |
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Average Molecular Weight | 597.0092 |
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Monoisotopic Molecular Weight | 596.553231548 |
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IUPAC Name | (1S,2R,5S,10S,11S,14R,15R)-2,15-dimethyl-14-[(2R)-6-methylheptan-2-yl]tetracyclo[8.7.0.0²,⁷.0¹¹,¹⁵]heptadec-7-en-5-yl tetradecanoate |
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Traditional Name | cholesteryl myristate |
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CAS Registry Number | 1989-52-2 |
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SMILES | [H][C@@]1(CC[C@@]2([H])[C@]3([H])CC=C4C[C@H](CC[C@]4(C)[C@@]3([H])CC[C@]12C)OC(=O)CCCCCCCCCCCCC)[C@H](C)CCCC(C)C |
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InChI Identifier | InChI=1S/C41H72O2/c1-7-8-9-10-11-12-13-14-15-16-17-21-39(42)43-34-26-28-40(5)33(30-34)22-23-35-37-25-24-36(32(4)20-18-19-31(2)3)41(37,6)29-27-38(35)40/h22,31-32,34-38H,7-21,23-30H2,1-6H3/t32-,34+,35+,36-,37+,38+,40+,41-/m1/s1 |
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InChI Key | SJDMTGSQPOFVLR-ZPQCIJQQSA-N |
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Chemical Taxonomy |
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Description | Belongs to the class of organic compounds known as cholesteryl esters. Cholesteryl esters are compounds containing an esterified cholestane moiety. |
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Kingdom | Organic compounds |
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Super Class | Lipids and lipid-like molecules |
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Class | Steroids and steroid derivatives |
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Sub Class | Steroid esters |
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Direct Parent | Cholesteryl esters |
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Alternative Parents | |
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Substituents | - Cholesteryl ester
- Cholesterol
- Cholestane-skeleton
- Delta-5-steroid
- Carboxylic acid ester
- Monocarboxylic acid or derivatives
- Carboxylic acid derivative
- Organic oxygen compound
- Organic oxide
- Hydrocarbon derivative
- Organooxygen compound
- Carbonyl group
- Aliphatic homopolycyclic compound
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Molecular Framework | Aliphatic homopolycyclic compounds |
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External Descriptors | |
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Ontology |
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Physiological effect | |
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Disposition | |
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Process | |
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Role | |
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Physical Properties |
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State | Solid |
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Experimental Molecular Properties | |
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Experimental Chromatographic Properties | Not Available |
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Predicted Molecular Properties | |
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Predicted Chromatographic Properties | Predicted Collision Cross SectionsPredicted Kovats Retention IndicesUnderivatized |
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| GC-MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted GC-MS | Predicted GC-MS Spectrum - CE(14:0) GC-MS (Non-derivatized) - 70eV, Positive | splash10-001i-4507290000-3f06572890d319781b7b | 2017-09-01 | Wishart Lab | View Spectrum |
MS/MS SpectraSpectrum Type | Description | Splash Key | Deposition Date | Source | View |
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Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 10V, Positive-QTOF | splash10-0002-1234090000-086ee9c6ba5fe624ef7d | 2016-09-14 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 20V, Positive-QTOF | splash10-029i-4629130000-78d47c2b38941bb08a07 | 2016-09-14 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 40V, Positive-QTOF | splash10-0a6r-4809110000-ea18e9a0b8a1032372ee | 2016-09-14 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 10V, Negative-QTOF | splash10-0002-0014090000-e27e6d10d38f16cbe8fc | 2016-09-14 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 20V, Negative-QTOF | splash10-000i-0139130000-b19ede8d7712f9ad5265 | 2016-09-14 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 40V, Negative-QTOF | splash10-0673-2029000000-d910fd5a36d78e535dcb | 2016-09-14 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 10V, Positive-QTOF | splash10-0002-6124090000-365bd93afde92e502b90 | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 20V, Positive-QTOF | splash10-0a4l-9210020000-2b8a648e3a36907b8c55 | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 40V, Positive-QTOF | splash10-0a4l-9210100000-2b34197ec1fb87b8955e | 2021-09-23 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 10V, Negative-QTOF | splash10-0002-0000090000-6e6dbfc2715e46f9dcef | 2021-09-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 20V, Negative-QTOF | splash10-052b-0091070000-e8c558e28d035b95c283 | 2021-09-24 | Wishart Lab | View Spectrum | Predicted LC-MS/MS | Predicted LC-MS/MS Spectrum - CE(14:0) 40V, Negative-QTOF | splash10-0a4l-2930020000-ea5df74ce3b18798a269 | 2021-09-24 | Wishart Lab | View Spectrum |
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