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Showing metabocard for Dimethylarsinic acid (HMDB0011625)

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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2009-01-30 09:50:05 UTC
Update Date2023-02-21 17:17:31 UTC
HMDB IDHMDB0011625
Secondary Accession Numbers
  • HMDB0094715
  • HMDB11625
  • HMDB94715
Metabolite Identification
Common NameDimethylarsinic acid
DescriptionDimethylarsinic acid, also known as cacodylic acid, is formally rated as possibly a carcinogenic (IARC 2B), potentially toxic compound. Derivatives of cacodylic acid, cacodylates, were frequently used as herbicides. For example, Agent Blue, one of the chemicals used during the Vietnam War, is a mixture of cacodylic acid and sodium cacodylate. Sodium cacodylate is frequently used as a buffering agent in the preparation and fixation of biological samples for transmission electron microscopy. Dimethylarsinic acid is highly toxic by ingestion, inhalation, or skin contact. Once thought to be a byproduct of inorganic arsenic detoxification, it is now believed to have serious health consequences of its own. It has been shown to be teratogenic in rodents, most often causing cleft palate but also fetal fatality at high doses. It has been shown to be genotoxic in human cells, causing apoptosis and also decreased DNA production and shorter DNA strands. While not itself a strong carcinogen, dimethylarsinic acid does promote tumours in the presence of carcinogens in organs such as the kidneys and liver (Wikipedia ).
Structure
Data?1676999851
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0011625 (Dimethylarsinic acid)

  Mrv1652305201900232D          

  5  4  0  0  0  0            999 V2000
    0.8250   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.0000    0.0000 As  0  0  0  0  0  5  0  0  0  0  0  0
    0.8250    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  2  0  0  0  0
  5  2  1  0  0  0  0
M  END
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3D MOL for HMDB0011625 (Dimethylarsinic acid)

HMDB0011625
     RDKit          3D
Dimethylarsinic acid
 12 11  0  0  0  0  0  0  0  0999 V2000
    1.6793   -0.2473   -0.3786 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0529    0.5601    0.4105 As  0  0  0  0  0  5  0  0  0  0  0  0
   -1.3613   -0.8229    0.1840 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3057    0.8288    1.9934 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4901    2.0322   -0.5054 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7142   -0.1314   -1.4664 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5415    0.2239    0.1408 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7087   -1.3285   -0.0538 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9227   -1.7639    0.5174 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2329   -0.4747    0.7323 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5097   -0.9027   -0.9160 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4858    2.0264   -0.6583 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  2  0
  2  5  1  0
  1  6  1  0
  1  7  1  0
  1  8  1  0
  3  9  1  0
  3 10  1  0
  3 11  1  0
  5 12  1  0
M  END
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3D SDF for HMDB0011625 (Dimethylarsinic acid)

  Mrv1652305201900232D          

  5  4  0  0  0  0            999 V2000
    0.8250   -0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.8250    0.0000    0.0000 As  0  0  0  0  0  5  0  0  0  0  0  0
    0.8250    0.8250    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.6500    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    0.0000    0.0000    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  2  3  1  0  0  0  0
  2  4  2  0  0  0  0
  5  2  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0011625

> <DATABASE_NAME>
hmdb

> <SMILES>
C[As](C)(O)=O

> <INCHI_IDENTIFIER>
InChI=1S/C2H7AsO2/c1-3(2,4)5/h1-2H3,(H,4,5)

> <INCHI_KEY>
OGGXGZAMXPVRFZ-UHFFFAOYSA-N

> <FORMULA>
C2H7AsO2

> <MOLECULAR_WEIGHT>
137.9974

> <EXACT_MASS>
137.966200885

> <JCHEM_ACCEPTOR_COUNT>
2

> <JCHEM_ATOM_COUNT>
12

> <JCHEM_AVERAGE_POLARIZABILITY>
9.178944868338649

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
1

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
dimethylarsinic acid

> <ALOGPS_LOGP>
-0.48

> <JCHEM_LOGP>
-0.32920000000000016

> <ALOGPS_LOGS>
0.27

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
0

> <JCHEM_PHYSIOLOGICAL_CHARGE>
-1

> <JCHEM_PKA_STRONGEST_ACIDIC>
6.222333786503422

> <JCHEM_POLAR_SURFACE_AREA>
37.3

> <JCHEM_REFRACTIVITY>
15.898900000000001

> <JCHEM_ROTATABLE_BOND_COUNT>
0

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
2.55e+02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
ansar

> <JCHEM_VEBER_RULE>
1

$$$$
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3D-SDF for HMDB0011625 (Dimethylarsinic acid)

HMDB0011625
     RDKit          3D
Dimethylarsinic acid
 12 11  0  0  0  0  0  0  0  0999 V2000
    1.6793   -0.2473   -0.3786 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.0529    0.5601    0.4105 As  0  0  0  0  0  5  0  0  0  0  0  0
   -1.3613   -0.8229    0.1840 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3057    0.8288    1.9934 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.4901    2.0322   -0.5054 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.7142   -0.1314   -1.4664 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5415    0.2239    0.1408 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.7087   -1.3285   -0.0538 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9227   -1.7639    0.5174 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.2329   -0.4747    0.7323 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.5097   -0.9027   -0.9160 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4858    2.0264   -0.6583 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  2  0
  2  5  1  0
  1  6  1  0
  1  7  1  0
  1  8  1  0
  3  9  1  0
  3 10  1  0
  3 11  1  0
  5 12  1  0
M  END
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PDB for HMDB0011625 (Dimethylarsinic acid)

HEADER    PROTEIN                                 20-MAY-19   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   20-MAY-19         0                                  
HETATM    1  C   UNK     0       1.540  -1.540   0.000  0.00  0.00           C+0
HETATM    2 As   UNK     0       1.540   0.000   0.000  0.00  0.00          As+0
HETATM    3  C   UNK     0       1.540   1.540   0.000  0.00  0.00           C+0
HETATM    4  O   UNK     0       3.080   0.000   0.000  0.00  0.00           O+0
HETATM    5  O   UNK     0       0.000   0.000   0.000  0.00  0.00           O+0
CONECT    1    2                                                            
CONECT    2    1    3    4    5                                             
CONECT    3    2                                                            
CONECT    4    2                                                            
CONECT    5    2                                                            
MASTER        0    0    0    0    0    0    0    0    5    0    8    0
END
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3D PDB for HMDB0011625 (Dimethylarsinic acid)

COMPND    HMDB0011625
HETATM    1  C1  UNL     1       1.679  -0.247  -0.379  1.00  0.00           C  
HETATM    2 AS1  UNL     1       0.053   0.560   0.410  1.00  0.00          AS  
HETATM    3  C2  UNL     1      -1.361  -0.823   0.184  1.00  0.00           C  
HETATM    4  O1  UNL     1       0.306   0.829   1.993  1.00  0.00           O  
HETATM    5  O2  UNL     1      -0.490   2.032  -0.505  1.00  0.00           O  
HETATM    6  H1  UNL     1       1.714  -0.131  -1.466  1.00  0.00           H  
HETATM    7  H2  UNL     1       2.542   0.224   0.141  1.00  0.00           H  
HETATM    8  H3  UNL     1       1.709  -1.328  -0.054  1.00  0.00           H  
HETATM    9  H4  UNL     1      -0.923  -1.764   0.517  1.00  0.00           H  
HETATM   10  H5  UNL     1      -2.233  -0.475   0.732  1.00  0.00           H  
HETATM   11  H6  UNL     1      -1.510  -0.903  -0.916  1.00  0.00           H  
HETATM   12  H7  UNL     1      -1.486   2.026  -0.658  1.00  0.00           H  
CONECT    1    2    6    7    8
CONECT    2    3    4    4    5
CONECT    3    9   10   11
CONECT    5   12
END
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SMILES for HMDB0011625 (Dimethylarsinic acid)

C[As](C)(O)=O
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INCHI for HMDB0011625 (Dimethylarsinic acid)

InChI=1S/C2H7AsO2/c1-3(2,4)5/h1-2H3,(H,4,5)
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View in JSmolView NMR AssignmentsView Stereo Labels
Synonyms
ValueSource
[As(CH3)2O(OH)]ChEBI
CACODYLIC ACIDChEBI
DimethylarsinateChEBI
KakodylsaeureChEBI
Me2as(=o)OHChEBI
CACODYLateGenerator
Acid, dimethylarsinicHMDB
Acid, cacodylicHMDB
As,as-dimethylarsinic acidHMDB
Dimethylarsenic acidHMDB
Hydroxydimethylarsine oxideHMDB
Dimethylarsinic acidGenerator
Chemical FormulaC2H7AsO2
Average Molecular Weight137.9974
Monoisotopic Molecular Weight137.966200885
IUPAC Namedimethylarsinic acid
Traditional Nameansar
CAS Registry Number75-60-5
SMILES
C[As](C)(O)=O
InChI Identifier
InChI=1S/C2H7AsO2/c1-3(2,4)5/h1-2H3,(H,4,5)
InChI KeyOGGXGZAMXPVRFZ-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as pentaorganoarsanes. These are organoarsenic compounds containing an arsenic compound that is pentasubstituted by only organic groups.
KingdomOrganic compounds
Super ClassOrganometallic compounds
ClassOrganometalloid compounds
Sub ClassOrganoarsenic compounds
Direct ParentPentaorganoarsanes
Alternative Parents
Substituents
  • Pentaorganoarsane
  • Alkylarsine oxide
  • Oxygen-containing organoarsenic compound
  • Organic metalloid salt
  • Organic oxygen compound
  • Organopnictogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organic salt
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect
Health effect
Disposition
Biological locationRoute of exposureSource
Process
Naturally occurring process
Role
Industrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M+H]+Not Available112.497http://allccs.zhulab.cn/database/detail?ID=AllCCS00001535
Predicted Molecular Properties
Predicted Chromatographic Properties
Spectra
Biological Properties
Cellular LocationsNot Available
Biospecimen Locations
  • Blood
  • Saliva
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB02994
Phenol Explorer Compound IDNot Available
FooDB IDFDB028327
KNApSAcK IDC00033777
Chemspider ID2418
KEGG Compound IDC07308
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkCacodylic_acid
METLIN IDNot Available
PubChem Compound2513
PDB IDNot Available
ChEBI ID48765
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Yamanaka K, Mizol M, Kato K, Hasegawa A, Nakano M, Okada S: Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenic, in mice promotes skin tumorigenesis initiated by dimethylbenz(a)anthracene with or without ultraviolet B as a promoter. Biol Pharm Bull. 2001 May;24(5):510-4. [PubMed:11379771 ]
  2. Maki T, Hirota W, Motojima H, Hasegawa H, Rahman MA: Influence of aggregated particles on biodegradation activities for dimethylarsinic acid (DMA) in Lake Kahokugata. Chemosphere. 2011 Jun;83(11):1486-92. doi: 10.1016/j.chemosphere.2011.01.059. Epub 2011 Feb 20. [PubMed:21342701 ]

Enzymes

Enzyme Details
1. Arsenite methyltransferase
General function:
Involved in methyltransferase activity
Specific function:
Catalyzes the transfer of a methyl group from AdoMet to trivalent arsenicals producing methylated and dimethylated arsenicals. It methylates arsenite to form methylarsonate, Me-AsO(3)H(2), which is reduced by methylarsonate reductase to methylarsonite, Me-As(OH)2. Methylarsonite is also a substrate and it is converted into the much less toxic compound dimethylarsinate (cacodylate), Me(2)As(O)-OH (By similarity).
Gene Name:
AS3MT
Uniprot ID:
Q9HBK9
Molecular weight:
41747.49
Reactions
S-Adenosylmethionine + Methylarsonite → S-Adenosylhomocysteine + Dimethylarsinic aciddetails