Hmdb loader
You are using an unsupported browser. Please upgrade your browser to a newer version to get the best experience on Human Metabolome Database.
Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:49 UTC
Update Date2022-03-07 02:51:39 UTC
HMDB IDHMDB0014515
Secondary Accession Numbers
  • HMDB14515
Metabolite Identification
Common NameMeprobamate
DescriptionA carbamate with hypnotic, sedative, and some muscle relaxant properties, although in therapeutic doses reduction of anxiety rather than a direct effect may be responsible for muscle relaxation. Meprobamate has been reported to have anticonvulsant actions against petit mal seizures, but not against grand mal seizures (which may be exacerbated). It is used in the treatment of anxiety disorders, and also for the short-term management of insomnia but has largely been superseded by the benzodiazepines. (From Martindale, The Extra Pharmacopoeia, 30th ed, p603) Meprobamate is a controlled substance in the U.S.
Structure
Data?1582753188
Synonyms
ValueSource
EquanilKegg
MiltownKegg
Meprobamic acidGenerator
DEA no. 2820HMDB
ProcarbamideHMDB
Alter brand OF meprobamateHMDB
Meprobamate alter brandHMDB
Meprobamate kade brandHMDB
Wallace brand 1 OF meprobamateHMDB
DapazHMDB
Méprobamate richardHMDB
TranmepHMDB
Wallace brand 2 OF meprobamateHMDB
Meprobamate richard brandHMDB
Richard brand OF meprobamateHMDB
Meprobamate wyeth brandHMDB
Sanofi synthelabo brand OF meprobamateHMDB
Reid rowell brand OF meprobamateHMDB
Wyeth brand OF meprobamateHMDB
Kade brand OF meprobamateHMDB
Meprobamate reid-rowell brandHMDB
MeprospanHMDB
Reid-rowell brand OF meprobamateHMDB
VisanoHMDB
Chemical FormulaC9H18N2O4
Average Molecular Weight218.2502
Monoisotopic Molecular Weight218.126657074
IUPAC Name2-[(carbamoyloxy)methyl]-2-methylpentyl carbamate
Traditional Namesowell
CAS Registry Number57-53-4
SMILES
CCCC(C)(COC(N)=O)COC(N)=O
InChI Identifier
InChI=1S/C9H18N2O4/c1-3-4-9(2,5-14-7(10)12)6-15-8(11)13/h3-6H2,1-2H3,(H2,10,12)(H2,11,13)
InChI KeyNPPQSCRMBWNHMW-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as carbamate esters. Carbamate esters are compounds containing an ester of carbamic acid with the general structure R2NC(=O)OR' (R' not H). They are esters of carbamic acids.
KingdomOrganic compounds
Super ClassOrganic acids and derivatives
ClassCarboxylic acids and derivatives
Sub ClassAmino acids, peptides, and analogues
Direct ParentCarbamate esters
Alternative Parents
Substituents
  • Carbamic acid ester
  • Carbonic acid derivative
  • Organic nitrogen compound
  • Organic oxygen compound
  • Organopnictogen compound
  • Organic oxide
  • Hydrocarbon derivative
  • Organooxygen compound
  • Organonitrogen compound
  • Carbonyl group
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External DescriptorsNot Available
Ontology
Disposition

Biological location

Process

Naturally occurring process

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point105 °CNot Available
Boiling PointNot AvailableNot Available
Water Solubility2.47 g/LNot Available
LogP0.7Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility2.47 g/LALOGPS
logP1.06ALOGPS
logP0.93ChemAxon
logS-2ALOGPS
pKa (Strongest Acidic)15.17ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count2ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area104.64 ŲChemAxon
Rotatable Bond Count8ChemAxon
Refractivity53.04 m³·mol⁻¹ChemAxon
Polarizability22.65 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+149.90131661259
DarkChem[M-H]-146.35831661259
DeepCCS[M+H]+155.630932474
DeepCCS[M-H]-152.38630932474
DeepCCS[M-2H]-188.67330932474
DeepCCS[M+Na]+164.41530932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
MeprobamateCCCC(C)(COC(N)=O)COC(N)=O2503.5Standard polar33892256
MeprobamateCCCC(C)(COC(N)=O)COC(N)=O1695.0Standard non polar33892256
MeprobamateCCCC(C)(COC(N)=O)COC(N)=O1788.7Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Meprobamate,1TMS,isomer #1CCCC(C)(COC(N)=O)COC(=O)N[Si](C)(C)C1902.1Semi standard non polar33892256
Meprobamate,1TMS,isomer #1CCCC(C)(COC(N)=O)COC(=O)N[Si](C)(C)C1827.7Standard non polar33892256
Meprobamate,1TMS,isomer #1CCCC(C)(COC(N)=O)COC(=O)N[Si](C)(C)C3000.8Standard polar33892256
Meprobamate,2TMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C)COC(=O)N[Si](C)(C)C2001.8Semi standard non polar33892256
Meprobamate,2TMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C)COC(=O)N[Si](C)(C)C1986.5Standard non polar33892256
Meprobamate,2TMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C)COC(=O)N[Si](C)(C)C2425.2Standard polar33892256
Meprobamate,2TMS,isomer #2CCCC(C)(COC(N)=O)COC(=O)N([Si](C)(C)C)[Si](C)(C)C1998.0Semi standard non polar33892256
Meprobamate,2TMS,isomer #2CCCC(C)(COC(N)=O)COC(=O)N([Si](C)(C)C)[Si](C)(C)C1933.9Standard non polar33892256
Meprobamate,2TMS,isomer #2CCCC(C)(COC(N)=O)COC(=O)N([Si](C)(C)C)[Si](C)(C)C2815.9Standard polar33892256
Meprobamate,3TMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C)COC(=O)N([Si](C)(C)C)[Si](C)(C)C2062.6Semi standard non polar33892256
Meprobamate,3TMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C)COC(=O)N([Si](C)(C)C)[Si](C)(C)C2056.9Standard non polar33892256
Meprobamate,3TMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C)COC(=O)N([Si](C)(C)C)[Si](C)(C)C2231.9Standard polar33892256
Meprobamate,4TMS,isomer #1CCCC(C)(COC(=O)N([Si](C)(C)C)[Si](C)(C)C)COC(=O)N([Si](C)(C)C)[Si](C)(C)C2111.5Semi standard non polar33892256
Meprobamate,4TMS,isomer #1CCCC(C)(COC(=O)N([Si](C)(C)C)[Si](C)(C)C)COC(=O)N([Si](C)(C)C)[Si](C)(C)C2157.5Standard non polar33892256
Meprobamate,4TMS,isomer #1CCCC(C)(COC(=O)N([Si](C)(C)C)[Si](C)(C)C)COC(=O)N([Si](C)(C)C)[Si](C)(C)C2074.9Standard polar33892256
Meprobamate,1TBDMS,isomer #1CCCC(C)(COC(N)=O)COC(=O)N[Si](C)(C)C(C)(C)C2134.7Semi standard non polar33892256
Meprobamate,1TBDMS,isomer #1CCCC(C)(COC(N)=O)COC(=O)N[Si](C)(C)C(C)(C)C2025.7Standard non polar33892256
Meprobamate,1TBDMS,isomer #1CCCC(C)(COC(N)=O)COC(=O)N[Si](C)(C)C(C)(C)C2991.4Standard polar33892256
Meprobamate,2TBDMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C(C)(C)C)COC(=O)N[Si](C)(C)C(C)(C)C2456.1Semi standard non polar33892256
Meprobamate,2TBDMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C(C)(C)C)COC(=O)N[Si](C)(C)C(C)(C)C2295.0Standard non polar33892256
Meprobamate,2TBDMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C(C)(C)C)COC(=O)N[Si](C)(C)C(C)(C)C2539.5Standard polar33892256
Meprobamate,2TBDMS,isomer #2CCCC(C)(COC(N)=O)COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2445.4Semi standard non polar33892256
Meprobamate,2TBDMS,isomer #2CCCC(C)(COC(N)=O)COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2344.5Standard non polar33892256
Meprobamate,2TBDMS,isomer #2CCCC(C)(COC(N)=O)COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2814.5Standard polar33892256
Meprobamate,3TBDMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C(C)(C)C)COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2722.6Semi standard non polar33892256
Meprobamate,3TBDMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C(C)(C)C)COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2554.2Standard non polar33892256
Meprobamate,3TBDMS,isomer #1CCCC(C)(COC(=O)N[Si](C)(C)C(C)(C)C)COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2513.4Standard polar33892256
Meprobamate,4TBDMS,isomer #1CCCC(C)(COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2940.7Semi standard non polar33892256
Meprobamate,4TBDMS,isomer #1CCCC(C)(COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2831.2Standard non polar33892256
Meprobamate,4TBDMS,isomer #1CCCC(C)(COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C)COC(=O)N([Si](C)(C)C(C)(C)C)[Si](C)(C)C(C)(C)C2494.5Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Meprobamate EI-B (Non-derivatized)splash10-053u-9100000000-d890d15ca6738ce72f602017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Meprobamate EI-B (Non-derivatized)splash10-053u-9100000000-d890d15ca6738ce72f602018-05-18HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Meprobamate GC-MS (Non-derivatized) - 70eV, Positivesplash10-0006-9300000000-825aaefb8c418b2efba22017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Meprobamate GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Meprobamate GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate LC-ESI-QTOF , positive-QTOFsplash10-0a4i-1900000000-8dd8e00d9af9bce5cd262017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate LC-ESI-QTOF , positive-QTOFsplash10-052b-9100000000-c21398e92cac7b48f5672017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate LC-ESI-QTOF , positive-QTOFsplash10-0a4i-9000000000-dd49a24a00b896129dbb2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate LC-ESI-QTOF , positive-QTOFsplash10-0a4i-9000000000-c537c5c82280244f09742017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate LC-ESI-QTOF , positive-QTOFsplash10-0a4i-9000000000-f351c8e0d2b10b45fdc92017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate 20V, Positive-QTOFsplash10-052b-9100000000-353e329af17fdea1fe112021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate 50V, Positive-QTOFsplash10-0a4i-9000000000-f351c8e0d2b10b45fdc92021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate 35V, Positive-QTOFsplash10-0a4i-9100000000-06d1583af444a66f06a62021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate 20V, Positive-QTOFsplash10-052b-9100000000-c21398e92cac7b48f5672021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate 10V, Positive-QTOFsplash10-0a4i-1900000000-8dd8e00d9af9bce5cd262021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate 30V, Positive-QTOFsplash10-0a4i-9000000000-dd49a24a00b896129dbb2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Meprobamate 40V, Positive-QTOFsplash10-0a4i-9000000000-c537c5c82280244f09742021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 10V, Positive-QTOFsplash10-014i-2390000000-a65c0efdab59106213892016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 20V, Positive-QTOFsplash10-05mo-7920000000-fa1a6af828f9e30ea8632016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 40V, Positive-QTOFsplash10-0006-9300000000-6c3c492ff4f56df352232016-08-01Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 10V, Negative-QTOFsplash10-0006-9110000000-8eddafdbe10b84364ba72016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 20V, Negative-QTOFsplash10-0006-9000000000-e4ee5bd6d8f75f6b65f32016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 40V, Negative-QTOFsplash10-0006-9000000000-bff1b038d3e9b7bb7e662016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 10V, Negative-QTOFsplash10-0fyo-5920000000-1571111c2e644492b2b02021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 20V, Negative-QTOFsplash10-01si-5900000000-f6410fb88e2d59529dfe2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 40V, Negative-QTOFsplash10-01ox-9200000000-d12d6480357bf7a6b0962021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 10V, Positive-QTOFsplash10-052b-9810000000-801cf45e01a3599d3dc82021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 20V, Positive-QTOFsplash10-0002-9300000000-838b738f0c6ecba6d36f2021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Meprobamate 40V, Positive-QTOFsplash10-01po-9000000000-238824ddc0f52f3b70fb2021-09-24Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-25Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00371 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00371 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00371
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID3924
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkMeprobamate
METLIN IDNot Available
PubChem Compound4064
PDB IDNot Available
ChEBI ID199389
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General ReferencesNot Available

Enzymes

General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in monooxygenase activity
Specific function:
Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. Inactivates a number of drugs and xenobiotics and also bioactivates many xenobiotic substrates to their hepatotoxic or carcinogenic forms.
Gene Name:
CYP2E1
Uniprot ID:
P05181
Molecular weight:
56848.42
References
  1. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA1
Uniprot ID:
P14867
Molecular weight:
51801.4
References
  1. Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. [PubMed:9067327 ]
  2. Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. doi: 10.1124/jpet.109.151142. Epub 2009 Feb 24. [PubMed:19244096 ]
  3. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA2
Uniprot ID:
P47869
Molecular weight:
51325.9
References
  1. Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. [PubMed:9067327 ]
  2. Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. doi: 10.1124/jpet.109.151142. Epub 2009 Feb 24. [PubMed:19244096 ]
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA3
Uniprot ID:
P34903
Molecular weight:
55164.1
References
  1. Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. [PubMed:9067327 ]
  2. Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. doi: 10.1124/jpet.109.151142. Epub 2009 Feb 24. [PubMed:19244096 ]
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA4
Uniprot ID:
P48169
Molecular weight:
61622.6
References
  1. Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. [PubMed:9067327 ]
  2. Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. doi: 10.1124/jpet.109.151142. Epub 2009 Feb 24. [PubMed:19244096 ]
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA5
Uniprot ID:
P31644
Molecular weight:
52145.6
References
  1. Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. [PubMed:9067327 ]
  2. Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. doi: 10.1124/jpet.109.151142. Epub 2009 Feb 24. [PubMed:19244096 ]
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA6
Uniprot ID:
Q16445
Molecular weight:
51023.7
References
  1. Rho JM, Donevan SD, Rogawski MA: Barbiturate-like actions of the propanediol dicarbamates felbamate and meprobamate. J Pharmacol Exp Ther. 1997 Mar;280(3):1383-91. [PubMed:9067327 ]
  2. Gonzalez LA, Gatch MB, Taylor CM, Bell-Horner CL, Forster MJ, Dillon GH: Carisoprodol-mediated modulation of GABAA receptors: in vitro and in vivo studies. J Pharmacol Exp Ther. 2009 May;329(2):827-37. doi: 10.1124/jpet.109.151142. Epub 2009 Feb 24. [PubMed:19244096 ]

Transporters

General function:
Involved in ATP binding
Specific function:
Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells
Gene Name:
ABCB1
Uniprot ID:
P08183
Molecular weight:
141477.3
References
  1. Mahar Doan KM, Humphreys JE, Webster LO, Wring SA, Shampine LJ, Serabjit-Singh CJ, Adkison KK, Polli JW: Passive permeability and P-glycoprotein-mediated efflux differentiate central nervous system (CNS) and non-CNS marketed drugs. J Pharmacol Exp Ther. 2002 Dec;303(3):1029-37. [PubMed:12438524 ]