Hmdb loader

Showing metabocard for Adinazolam (HMDB0014686)

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enzymes (18) Show 18 proteins
Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-06 15:16:50 UTC
Update Date2022-03-07 02:51:42 UTC
HMDB IDHMDB0014686
Secondary Accession Numbers
  • HMDB14686
Metabolite Identification
Common NameAdinazolam
DescriptionAdinazolam is only found in individuals that have used or taken this drug. It is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative, and antidepressant properties. Adinazolam was developed by Dr. Jackson B. Hester, who was seeking to enhance the antidepressant properties of alprazolam, which he also developed.Adinazolam binds to peripheral-type benzodiazepine receptors which interact allosterically with GABA receptors. This potentiates the effects of the inhibitory neurotransmitter GABA, increasing the inhibition of the ascending reticular activating system and blocking the cortical and limbic arousal that occurs following stimulation of the reticular pathways.
Structure
Data?1582753208
MOL3D MOLSDF3D SDFPDB3D PDBSMILESInChI

MOL for HMDB0014686 (Adinazolam)

546
  Mrv0541 02231214452D          

 25 28  0  0  0  0            999 V2000
    1.6500    0.4541    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.8159   -0.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5298   -2.8254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2284    1.1666    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7352   -1.5988    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1244   -0.8770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0726   -0.2827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9281   -1.4531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5592   -0.2827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8890    0.5217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3328   -2.0242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7428    0.5217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4034    1.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4517   -0.8769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0718    0.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0454    1.9100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6286   -0.6299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4374    0.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9344   -3.3965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3220   -3.0553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2227    1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5102    2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8648    2.7149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1523    3.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3296    3.3965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 18  1  0  0  0  0
  2  7  1  0  0  0  0
  2  8  1  0  0  0  0
  2  9  1  0  0  0  0
  3 11  1  0  0  0  0
  3 19  1  0  0  0  0
  3 20  1  0  0  0  0
  4 12  1  0  0  0  0
  4 13  2  0  0  0  0
  5  6  1  0  0  0  0
  5  8  2  0  0  0  0
  6  9  2  0  0  0  0
  7 10  2  0  0  0  0
  7 14  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
 16 21  2  0  0  0  0
 16 22  1  0  0  0  0
 17 18  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
Download

3D MOL for HMDB0014686 (Adinazolam)

HMDB0014686
     RDKit          3D
Adinazolam
 43 46  0  0  0  0  0  0  0  0999 V2000
    5.0013    0.2207    1.2221 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3002    0.0191   -0.0192 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0324   -0.9819   -0.7773 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9697   -0.4855    0.2679 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1162   -0.7473   -0.8865 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3385   -1.6211   -1.9253 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -1.6330   -2.7417 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3656   -0.8047   -2.2727 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9132   -0.2712   -1.1358 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2718    0.7125   -0.3313 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1574    1.6262    0.1543 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6147    2.6621    0.9021 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7719    2.7279    1.1151 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4972    4.0074    2.0490 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6255    1.7793    0.5969 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1174    0.7488   -0.1346 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1310   -0.1653   -0.6324 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2692   -0.4428    0.1806 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4950   -0.1198    1.4693 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6726   -0.3380    2.1589 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7194   -0.9325    1.5148 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5577   -1.2917    0.1992 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3768   -1.0614   -0.4615 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0115   -0.6994   -1.8199 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9777   -0.5672   -2.8402 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2252    0.4468    1.9949 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5991   -0.6690    1.4705 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6202    1.1365    1.1122 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9041   -0.8613   -1.8701 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7965   -2.0035   -0.4194 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1059   -0.7925   -0.5658 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5150   -0.1463    1.1945 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2380   -1.5630    0.6164 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1825    1.6020   -0.0696 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2638    3.4097    1.3143 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6962    1.8562    0.6917 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6710    0.2862    2.0670 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7262   -0.0291    3.1901 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6298   -1.0941    2.0699 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4091   -1.7625   -0.2801 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2847   -1.3548   -1.4889 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0192    0.4597   -3.2121 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1388   -1.2622   -3.6671 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 17 24  2  0
 24 25  1  0
  9  5  1  0
 16 10  1  0
 23 18  1  0
 25  8  1  0
  1 26  1  0
  1 27  1  0
  1 28  1  0
  3 29  1  0
  3 30  1  0
  3 31  1  0
  4 32  1  0
  4 33  1  0
 11 34  1  0
 12 35  1  0
 15 36  1  0
 19 37  1  0
 20 38  1  0
 21 39  1  0
 22 40  1  0
 23 41  1  0
 25 42  1  0
 25 43  1  0
M  END
Download

3D SDF for HMDB0014686 (Adinazolam)

546
  Mrv0541 02231214452D          

 25 28  0  0  0  0            999 V2000
    1.6500    0.4541    0.0000 Cl  0  0  0  0  0  0  0  0  0  0  0  0
    4.8159   -0.6407    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.5298   -2.8254    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.2284    1.1666    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.7352   -1.5988    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    6.1244   -0.8770    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    4.0726   -0.2827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.9281   -1.4531    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.5592   -0.2827    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.8890    0.5217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3328   -2.0242    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.7428    0.5217    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.4034    1.1666    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.4517   -0.8769    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.0718    0.7875    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.0454    1.9100    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.6286   -0.6299    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.4374    0.2079    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.9344   -3.3965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    5.3220   -3.0553    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2227    1.9716    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.5102    2.5916    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.8648    2.7149    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.1523    3.3349    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.3296    3.3965    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
  1 18  1  0  0  0  0
  2  7  1  0  0  0  0
  2  8  1  0  0  0  0
  2  9  1  0  0  0  0
  3 11  1  0  0  0  0
  3 19  1  0  0  0  0
  3 20  1  0  0  0  0
  4 12  1  0  0  0  0
  4 13  2  0  0  0  0
  5  6  1  0  0  0  0
  5  8  2  0  0  0  0
  6  9  2  0  0  0  0
  7 10  2  0  0  0  0
  7 14  1  0  0  0  0
  8 11  1  0  0  0  0
  9 12  1  0  0  0  0
 10 13  1  0  0  0  0
 10 15  1  0  0  0  0
 13 16  1  0  0  0  0
 14 17  2  0  0  0  0
 15 18  2  0  0  0  0
 16 21  2  0  0  0  0
 16 22  1  0  0  0  0
 17 18  1  0  0  0  0
 21 23  1  0  0  0  0
 22 24  2  0  0  0  0
 23 25  2  0  0  0  0
 24 25  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0014686

> <DATABASE_NAME>
hmdb

> <SMILES>
CN(C)CC1=NN=C2CN=C(C3=CC=CC=C3)C3=C(C=CC(Cl)=C3)N12

> <INCHI_IDENTIFIER>
InChI=1S/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3

> <INCHI_KEY>
GJSLOMWRLALDCT-UHFFFAOYSA-N

> <FORMULA>
C19H18ClN5

> <MOLECULAR_WEIGHT>
351.833

> <EXACT_MASS>
351.125073308

> <JCHEM_ACCEPTOR_COUNT>
4

> <JCHEM_AVERAGE_POLARIZABILITY>
37.153075062888746

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
0

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
1

> <JCHEM_IUPAC>
({12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,8,11,13-hexaen-3-yl}methyl)dimethylamine

> <ALOGPS_LOGP>
2.57

> <JCHEM_LOGP>
2.2406999999999995

> <ALOGPS_LOGS>
-3.72

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
4

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA_STRONGEST_ACIDIC>
18.384145210894495

> <JCHEM_PKA_STRONGEST_BASIC>
6.658641192163124

> <JCHEM_POLAR_SURFACE_AREA>
46.31

> <JCHEM_REFRACTIVITY>
112.308

> <JCHEM_ROTATABLE_BOND_COUNT>
3

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
6.72e-02 g/l

> <JCHEM_TRADITIONAL_IUPAC>
adinazolam

> <JCHEM_VEBER_RULE>
0

$$$$
Download

3D-SDF for HMDB0014686 (Adinazolam)

HMDB0014686
     RDKit          3D
Adinazolam
 43 46  0  0  0  0  0  0  0  0999 V2000
    5.0013    0.2207    1.2221 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.3002    0.0191   -0.0192 N   0  0  0  0  0  0  0  0  0  0  0  0
    5.0324   -0.9819   -0.7773 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.9697   -0.4855    0.2679 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.1162   -0.7473   -0.8865 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.3385   -1.6211   -1.9253 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2665   -1.6330   -2.7417 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.3656   -0.8047   -2.2727 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.9132   -0.2712   -1.1358 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.2718    0.7125   -0.3313 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1574    1.6262    0.1543 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.6147    2.6621    0.9021 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.7719    2.7279    1.1151 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.4972    4.0074    2.0490 Cl  0  0  0  0  0  0  0  0  0  0  0  0
   -1.6255    1.7793    0.5969 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1174    0.7488   -0.1346 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1310   -0.1653   -0.6324 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2692   -0.4428    0.1806 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.4950   -0.1198    1.4693 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.6726   -0.3380    2.1589 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.7194   -0.9325    1.5148 C   0  0  0  0  0  0  0  0  0  0  0  0
   -5.5577   -1.2917    0.1992 C   0  0  0  0  0  0  0  0  0  0  0  0
   -4.3768   -1.0614   -0.4615 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.0115   -0.6994   -1.8199 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9777   -0.5672   -2.8402 C   0  0  0  0  0  0  0  0  0  0  0  0
    4.2252    0.4468    1.9949 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5991   -0.6690    1.4705 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.6202    1.1365    1.1122 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.9041   -0.8613   -1.8701 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.7965   -2.0035   -0.4194 H   0  0  0  0  0  0  0  0  0  0  0  0
    6.1059   -0.7925   -0.5658 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.5150   -0.1463    1.1945 H   0  0  0  0  0  0  0  0  0  0  0  0
    3.2380   -1.5630    0.6164 H   0  0  0  0  0  0  0  0  0  0  0  0
    2.1825    1.6020   -0.0696 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.2638    3.4097    1.3143 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6962    1.8562    0.6917 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6710    0.2862    2.0670 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.7262   -0.0291    3.1901 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.6298   -1.0941    2.0699 H   0  0  0  0  0  0  0  0  0  0  0  0
   -6.4091   -1.7625   -0.2801 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.2847   -1.3548   -1.4889 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.0192    0.4597   -3.2121 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1388   -1.2622   -3.6671 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0
  2  3  1  0
  2  4  1  0
  4  5  1  0
  5  6  2  0
  6  7  1  0
  7  8  2  0
  8  9  1  0
  9 10  1  0
 10 11  2  0
 11 12  1  0
 12 13  2  0
 13 14  1  0
 13 15  1  0
 15 16  2  0
 16 17  1  0
 17 18  1  0
 18 19  2  0
 19 20  1  0
 20 21  2  0
 21 22  1  0
 22 23  2  0
 17 24  2  0
 24 25  1  0
  9  5  1  0
 16 10  1  0
 23 18  1  0
 25  8  1  0
  1 26  1  0
  1 27  1  0
  1 28  1  0
  3 29  1  0
  3 30  1  0
  3 31  1  0
  4 32  1  0
  4 33  1  0
 11 34  1  0
 12 35  1  0
 15 36  1  0
 19 37  1  0
 20 38  1  0
 21 39  1  0
 22 40  1  0
 23 41  1  0
 25 42  1  0
 25 43  1  0
M  END
Download

PDB for HMDB0014686 (Adinazolam)

HEADER    PROTEIN                                 23-FEB-12   NONE
TITLE     NULL                                                        
COMPND    MOLECULE: 546                                               
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   23-FEB-12         0                                  
HETATM    1 Cl   UNK     0       3.080   0.848   0.000  0.00  0.00          Cl+0
HETATM    2  N   UNK     0       8.990  -1.196   0.000  0.00  0.00           N+0
HETATM    3  N   UNK     0       8.456  -5.274   0.000  0.00  0.00           N+0
HETATM    4  N   UNK     0       9.760   2.178   0.000  0.00  0.00           N+0
HETATM    5  N   UNK     0      10.706  -2.984   0.000  0.00  0.00           N+0
HETATM    6  N   UNK     0      11.432  -1.637   0.000  0.00  0.00           N+0
HETATM    7  C   UNK     0       7.602  -0.528   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0       9.199  -2.712   0.000  0.00  0.00           C+0
HETATM    9  C   UNK     0      10.377  -0.528   0.000  0.00  0.00           C+0
HETATM   10  C   UNK     0       7.259   0.974   0.000  0.00  0.00           C+0
HETATM   11  C   UNK     0       8.088  -3.779   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      10.720   0.974   0.000  0.00  0.00           C+0
HETATM   13  C   UNK     0       8.220   2.178   0.000  0.00  0.00           C+0
HETATM   14  C   UNK     0       6.443  -1.637   0.000  0.00  0.00           C+0
HETATM   15  C   UNK     0       5.734   1.470   0.000  0.00  0.00           C+0
HETATM   16  C   UNK     0       7.551   3.565   0.000  0.00  0.00           C+0
HETATM   17  C   UNK     0       4.907  -1.176   0.000  0.00  0.00           C+0
HETATM   18  C   UNK     0       4.550   0.388   0.000  0.00  0.00           C+0
HETATM   19  C   UNK     0       7.344  -6.340   0.000  0.00  0.00           C+0
HETATM   20  C   UNK     0       9.934  -5.703   0.000  0.00  0.00           C+0
HETATM   21  C   UNK     0       6.016   3.680   0.000  0.00  0.00           C+0
HETATM   22  C   UNK     0       8.419   4.838   0.000  0.00  0.00           C+0
HETATM   23  C   UNK     0       5.348   5.068   0.000  0.00  0.00           C+0
HETATM   24  C   UNK     0       7.751   6.225   0.000  0.00  0.00           C+0
HETATM   25  C   UNK     0       6.215   6.340   0.000  0.00  0.00           C+0
CONECT    1   18                                                            
CONECT    2    7    8    9                                                  
CONECT    3   11   19   20                                                  
CONECT    4   12   13                                                       
CONECT    5    6    8                                                       
CONECT    6    5    9                                                       
CONECT    7    2   10   14                                                  
CONECT    8    2    5   11                                                  
CONECT    9    2    6   12                                                  
CONECT   10    7   13   15                                                  
CONECT   11    3    8                                                       
CONECT   12    4    9                                                       
CONECT   13    4   10   16                                                  
CONECT   14    7   17                                                       
CONECT   15   10   18                                                       
CONECT   16   13   21   22                                                  
CONECT   17   14   18                                                       
CONECT   18    1   15   17                                                  
CONECT   19    3                                                            
CONECT   20    3                                                            
CONECT   21   16   23                                                       
CONECT   22   16   24                                                       
CONECT   23   21   25                                                       
CONECT   24   22   25                                                       
CONECT   25   23   24                                                       
MASTER        0    0    0    0    0    0    0    0   25    0   56    0
END
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3D PDB for HMDB0014686 (Adinazolam)

COMPND    HMDB0014686
HETATM    1  C1  UNL     1       5.001   0.221   1.222  1.00  0.00           C  
HETATM    2  N1  UNL     1       4.300   0.019  -0.019  1.00  0.00           N  
HETATM    3  C2  UNL     1       5.032  -0.982  -0.777  1.00  0.00           C  
HETATM    4  C3  UNL     1       2.970  -0.485   0.268  1.00  0.00           C  
HETATM    5  C4  UNL     1       2.116  -0.747  -0.887  1.00  0.00           C  
HETATM    6  N2  UNL     1       2.339  -1.621  -1.925  1.00  0.00           N  
HETATM    7  N3  UNL     1       1.266  -1.633  -2.742  1.00  0.00           N  
HETATM    8  C5  UNL     1       0.366  -0.805  -2.273  1.00  0.00           C  
HETATM    9  N4  UNL     1       0.913  -0.271  -1.136  1.00  0.00           N  
HETATM   10  C6  UNL     1       0.272   0.713  -0.331  1.00  0.00           C  
HETATM   11  C7  UNL     1       1.157   1.626   0.154  1.00  0.00           C  
HETATM   12  C8  UNL     1       0.615   2.662   0.902  1.00  0.00           C  
HETATM   13  C9  UNL     1      -0.772   2.728   1.115  1.00  0.00           C  
HETATM   14 CL1  UNL     1      -1.497   4.007   2.049  1.00  0.00          CL  
HETATM   15  C10 UNL     1      -1.625   1.779   0.597  1.00  0.00           C  
HETATM   16  C11 UNL     1      -1.117   0.749  -0.135  1.00  0.00           C  
HETATM   17  C12 UNL     1      -2.131  -0.165  -0.632  1.00  0.00           C  
HETATM   18  C13 UNL     1      -3.269  -0.443   0.181  1.00  0.00           C  
HETATM   19  C14 UNL     1      -3.495  -0.120   1.469  1.00  0.00           C  
HETATM   20  C15 UNL     1      -4.673  -0.338   2.159  1.00  0.00           C  
HETATM   21  C16 UNL     1      -5.719  -0.933   1.515  1.00  0.00           C  
HETATM   22  C17 UNL     1      -5.558  -1.292   0.199  1.00  0.00           C  
HETATM   23  C18 UNL     1      -4.377  -1.061  -0.462  1.00  0.00           C  
HETATM   24  N5  UNL     1      -2.011  -0.699  -1.820  1.00  0.00           N  
HETATM   25  C19 UNL     1      -0.978  -0.567  -2.840  1.00  0.00           C  
HETATM   26  H1  UNL     1       4.225   0.447   1.995  1.00  0.00           H  
HETATM   27  H2  UNL     1       5.599  -0.669   1.471  1.00  0.00           H  
HETATM   28  H3  UNL     1       5.620   1.137   1.112  1.00  0.00           H  
HETATM   29  H4  UNL     1       4.904  -0.861  -1.870  1.00  0.00           H  
HETATM   30  H5  UNL     1       4.796  -2.004  -0.419  1.00  0.00           H  
HETATM   31  H6  UNL     1       6.106  -0.793  -0.566  1.00  0.00           H  
HETATM   32  H7  UNL     1       2.515  -0.146   1.194  1.00  0.00           H  
HETATM   33  H8  UNL     1       3.238  -1.563   0.616  1.00  0.00           H  
HETATM   34  H9  UNL     1       2.182   1.602  -0.070  1.00  0.00           H  
HETATM   35  H10 UNL     1       1.264   3.410   1.314  1.00  0.00           H  
HETATM   36  H11 UNL     1      -2.696   1.856   0.692  1.00  0.00           H  
HETATM   37  H12 UNL     1      -2.671   0.286   2.067  1.00  0.00           H  
HETATM   38  H13 UNL     1      -4.726  -0.029   3.190  1.00  0.00           H  
HETATM   39  H14 UNL     1      -6.630  -1.094   2.070  1.00  0.00           H  
HETATM   40  H15 UNL     1      -6.409  -1.763  -0.280  1.00  0.00           H  
HETATM   41  H16 UNL     1      -4.285  -1.355  -1.489  1.00  0.00           H  
HETATM   42  H17 UNL     1      -1.019   0.460  -3.212  1.00  0.00           H  
HETATM   43  H18 UNL     1      -1.139  -1.262  -3.667  1.00  0.00           H  
CONECT    1    2   26   27   28
CONECT    2    3    4
CONECT    3   29   30   31
CONECT    4    5   32   33
CONECT    5    6    6    9
CONECT    6    7
CONECT    7    8    8
CONECT    8    9   25
CONECT    9   10
CONECT   10   11   11   16
CONECT   11   12   34
CONECT   12   13   13   35
CONECT   13   14   15
CONECT   15   16   16   36
CONECT   16   17
CONECT   17   18   24   24
CONECT   18   19   19   23
CONECT   19   20   37
CONECT   20   21   21   38
CONECT   21   22   39
CONECT   22   23   23   40
CONECT   23   41
CONECT   24   25
CONECT   25   42   43
END
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SMILES for HMDB0014686 (Adinazolam)

CN(C)CC1=NN=C2CN=C(C3=CC=CC=C3)C3=C(C=CC(Cl)=C3)N12
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INCHI for HMDB0014686 (Adinazolam)

InChI=1S/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3
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View in JSmolView Stereo Labels
Synonyms
ValueSource
8-Chloro-1-((dimethylamino)methyl)-6-phenyl-4H-S-triazolo(4,3-a)(1,4)benzodiazepineChEBI
AdinazolamumChEBI
Chemical FormulaC19H18ClN5
Average Molecular Weight351.833
Monoisotopic Molecular Weight351.125073308
IUPAC Name({12-chloro-9-phenyl-2,4,5,8-tetraazatricyclo[8.4.0.0²,⁶]tetradeca-1(10),3,5,8,11,13-hexaen-3-yl}methyl)dimethylamine
Traditional Nameadinazolam
CAS Registry Number37115-32-5
SMILES
CN(C)CC1=NN=C2CN=C(C3=CC=CC=C3)C3=C(C=CC(Cl)=C3)N12
InChI Identifier
InChI=1S/C19H18ClN5/c1-24(2)12-18-23-22-17-11-21-19(13-6-4-3-5-7-13)15-10-14(20)8-9-16(15)25(17)18/h3-10H,11-12H2,1-2H3
InChI KeyGJSLOMWRLALDCT-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 1,2,4-triazolo[4,3-a][1,4]benzodiazepines. These are aromatic compounds containing a 1,4-benzodiazepine fused to and sharing a nitrogen atom with a 1,2,4-triazole ring.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassBenzodiazepines
Sub Class1,4-benzodiazepines
Direct Parent1,2,4-triazolo[4,3-a][1,4]benzodiazepines
Alternative Parents
Substituents
  • 1,2,4-triazolo[4,3-a][1,4]benzodiazepine
  • Aralkylamine
  • Aryl chloride
  • Aryl halide
  • Monocyclic benzene moiety
  • Benzenoid
  • Azole
  • Heteroaromatic compound
  • 1,2,4-triazole
  • Ketimine
  • Tertiary amine
  • Tertiary aliphatic amine
  • Azacycle
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Organohalogen compound
  • Imine
  • Amine
  • Hydrocarbon derivative
  • Organopnictogen compound
  • Organochloride
  • Organonitrogen compound
  • Organic nitrogen compound
  • Aromatic heteropolycyclic compound
Molecular FrameworkAromatic heteropolycyclic compounds
External Descriptors
Ontology
Physiological effectNot Available
Disposition
Biological location
ProcessNot Available
RoleNot Available
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water Solubility0.067 g/LNot Available
LogP4.4Not Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility0.067 g/LALOGPS
logP2.57ALOGPS
logP2.24ChemAxon
logS-3.7ALOGPS
pKa (Strongest Acidic)18.38ChemAxon
pKa (Strongest Basic)6.66ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area46.31 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity112.31 m³·mol⁻¹ChemAxon
Polarizability37.15 ųChemAxon
Number of Rings4ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterYesChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M-2H]-212.73330932474
DeepCCS[M+Na]+187.9630932474
AllCCS[M+H]+182.132859911
AllCCS[M+H-H2O]+178.932859911
AllCCS[M+NH4]+185.032859911
AllCCS[M+Na]+185.832859911
AllCCS[M-H]-186.132859911
AllCCS[M+Na-2H]-185.632859911
AllCCS[M+HCOO]-185.132859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
AdinazolamCN(C)CC1=NN=C2CN=C(C3=CC=CC=C3)C3=C(C=CC(Cl)=C3)N124105.0Standard polar33892256
AdinazolamCN(C)CC1=NN=C2CN=C(C3=CC=CC=C3)C3=C(C=CC(Cl)=C3)N123090.2Standard non polar33892256
AdinazolamCN(C)CC1=NN=C2CN=C(C3=CC=CC=C3)C3=C(C=CC(Cl)=C3)N122971.7Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - Adinazolam GC-MS (Non-derivatized) - 70eV, Positivesplash10-05nf-9033000000-0dc8d0feb0b685bc12ae2017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Adinazolam GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 10V, Positive-QTOFsplash10-0udi-0009000000-acca3b4d4884fba517062016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 20V, Positive-QTOFsplash10-0pb9-1019000000-7c41944a85dcc729e45f2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 40V, Positive-QTOFsplash10-0hfx-3190000000-b82f1f870cf76916bf202016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 10V, Negative-QTOFsplash10-0udi-0049000000-fb3a7658eafc13c094db2016-08-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 20V, Negative-QTOFsplash10-0udi-0029000000-1313138f4f4195a6ef1f2016-08-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 40V, Negative-QTOFsplash10-0udi-5390000000-041b41562f98430e82d12016-08-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 10V, Negative-QTOFsplash10-0udi-0009000000-159cbcb4fa82133969982021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 20V, Negative-QTOFsplash10-0udl-0079000000-7e55a3a3ae2a7a4f27f02021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 40V, Negative-QTOFsplash10-001l-8093000000-1bad2fb50e123dce6fb02021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 10V, Positive-QTOFsplash10-0udi-0009000000-aa3e66600d2c48d83b922021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 20V, Positive-QTOFsplash10-0udi-0009000000-7bacef72504159c671832021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Adinazolam 40V, Positive-QTOFsplash10-057i-2092000000-e2d272101c1e0ddf2ef42021-09-24Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Membrane
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00546 details
UrineExpected but not QuantifiedNot QuantifiedNot AvailableNot AvailableTaking drug identified by DrugBank entry DB00546 details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB00546
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider ID34519
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkAdinazolam
METLIN IDNot Available
PubChem Compound37632
PDB IDNot Available
ChEBI ID251412
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. 1983 Nov;22(11):1277-82. [PubMed:6320036 ]
  2. Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984 Aug;36(8):546-8. [PubMed:6148400 ]
  3. File SE, Pellow S: Triazolobenzodiazepines antagonize the effects of anxiogenic drugs mediated at three different central nervous system sites. Neurosci Lett. 1985 Oct 24;61(1-2):115-9. [PubMed:2867497 ]

Only showing the first 10 proteins. There are 18 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details
1. Cytochrome P450 3A4
General function:
Involved in monooxygenase activity
Specific function:
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It performs a variety of oxidation reactions (e.g. caffeine 8-oxidation, omeprazole sulphoxidation, midazolam 1'-hydroxylation and midazolam 4-hydroxylation) of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. Acts as a 1,8-cineole 2-exo-monooxygenase. The enzyme also hydroxylates etoposide.
Gene Name:
CYP3A4
Uniprot ID:
P08684
Molecular weight:
57255.585
References
  1. Venkatakrishnan K, von Moltke LL, Duan SX, Fleishaker JC, Shader RI, Greenblatt DJ: Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. J Pharm Pharmacol. 1998 Mar;50(3):265-74. [PubMed:9600717 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
2. Cytochrome P450 2C19
General function:
Involved in monooxygenase activity
Specific function:
Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine.
Gene Name:
CYP2C19
Uniprot ID:
P33261
Molecular weight:
55944.565
References
  1. Venkatakrishnan K, von Moltke LL, Duan SX, Fleishaker JC, Shader RI, Greenblatt DJ: Kinetic characterization and identification of the enzymes responsible for the hepatic biotransformation of adinazolam and N-desmethyladinazolam in man. J Pharm Pharmacol. 1998 Mar;50(3):265-74. [PubMed:9600717 ]
  2. Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. doi: 10.1093/nar/gkp970. Epub 2009 Nov 24. [PubMed:19934256 ]
Enzyme Details
3. Gamma-aminobutyric acid receptor subunit gamma-2
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRG2
Uniprot ID:
P18507
Molecular weight:
54161.8
References
  1. Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. 1983 Nov;22(11):1277-82. [PubMed:6320036 ]
  2. Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984 Aug;36(8):546-8. [PubMed:6148400 ]
Enzyme Details
4. Gamma-aminobutyric acid receptor subunit alpha-1
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA1
Uniprot ID:
P14867
Molecular weight:
51801.4
References
  1. Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. 1983 Nov;22(11):1277-82. [PubMed:6320036 ]
  2. Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984 Aug;36(8):546-8. [PubMed:6148400 ]
Enzyme Details
5. Gamma-aminobutyric acid receptor subunit alpha-2
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA2
Uniprot ID:
P47869
Molecular weight:
51325.9
References
  1. Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. 1983 Nov;22(11):1277-82. [PubMed:6320036 ]
  2. Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984 Aug;36(8):546-8. [PubMed:6148400 ]
Enzyme Details
6. Gamma-aminobutyric acid receptor subunit alpha-3
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA3
Uniprot ID:
P34903
Molecular weight:
55164.1
References
  1. Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. 1983 Nov;22(11):1277-82. [PubMed:6320036 ]
  2. Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984 Aug;36(8):546-8. [PubMed:6148400 ]
Enzyme Details
7. Gamma-aminobutyric acid receptor subunit alpha-5
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRA5
Uniprot ID:
P31644
Molecular weight:
52145.6
References
  1. Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. 1983 Nov;22(11):1277-82. [PubMed:6320036 ]
  2. Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984 Aug;36(8):546-8. [PubMed:6148400 ]
Enzyme Details
8. Gamma-aminobutyric acid receptor subunit beta-1
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRB1
Uniprot ID:
P18505
Molecular weight:
54234.1
References
  1. Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. 1983 Nov;22(11):1277-82. [PubMed:6320036 ]
  2. Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984 Aug;36(8):546-8. [PubMed:6148400 ]
Enzyme Details
9. Gamma-aminobutyric acid receptor subunit beta-2
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRB2
Uniprot ID:
P47870
Molecular weight:
59149.9
References
  1. Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. 1983 Nov;22(11):1277-82. [PubMed:6320036 ]
  2. Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984 Aug;36(8):546-8. [PubMed:6148400 ]
Enzyme Details
10. Gamma-aminobutyric acid receptor subunit beta-3
General function:
Involved in ion transport
Specific function:
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel
Gene Name:
GABRB3
Uniprot ID:
P28472
Molecular weight:
54115.0
References
  1. Lahti RA, Sethy VH, Barsuhn C, Hester JB: Pharmacological profile of the antidepressant adinazolam, a triazolobenzodiazepine. Neuropharmacology. 1983 Nov;22(11):1277-82. [PubMed:6320036 ]
  2. Sethy VH, Collins RJ, Daniels EG: Determination of biological activity of adinazolam and its metabolites. J Pharm Pharmacol. 1984 Aug;36(8):546-8. [PubMed:6148400 ]

Only showing the first 10 proteins. There are 18 proteins in total.

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