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Record Information
Version5.0
StatusPredicted
Creation Date2021-09-12 11:24:51 UTC
Update Date2022-03-06 23:26:33 UTC
HMDB IDHMDB0266529
Secondary Accession NumbersNone
Metabolite Identification
Common NamePA(2:0/5-iso PGF2VI)
DescriptionPA(2:0/5-iso PGF2VI) is an oxidized phosphatidic acid (PA). Oxidized phosphatidic acids are glycerophospholipids in which a phosphate moiety occupies a glycerol substitution site and at least one of the fatty acyl chains has undergone oxidation. As all oxidized lipids, oxidized phosphatidic acids belong to a group of biomolecules that have a role as signaling molecules. The biosynthesis of oxidized lipids is mediated by several enzymatic families, including cyclooxygenases (COX), lipoxygenases (LOX) and cytochrome P450s (CYP). Non-enzymatically oxidized lipids are produced by uncontrolled oxidation through free radicals and are considered harmful to human health (PMID: 33329396 ). As is the case with diacylglycerols, phosphatidic acids can have many different combinations of fatty acids of varying lengths, saturation and degrees of oxidation attached at the C-1 and C-2 positions. PA(2:0/5-iso PGF2VI), in particular, consists of one chain of one acetyl at the C-1 position and one chain of 5-iso Prostaglandin F2alpha-VI at the C-2 position. Phospholipids are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling. Similarly to what occurs with phospholipids, the fatty acid distribution at the C-1 and C-2 positions of glycerol within oxidized phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. Oxidized PAs can be synthesized via three different routes. In one route, the oxidized PA is synthetized de novo following the same mechanisms as for PAs but incorporating oxidized acyl chains (PMID: 33329396 ). An alternative is the transacylation of one of the non-oxidized acyl chains with an oxidized acylCoA (PMID: 33329396 ). The third pathway results from the oxidation of the acyl chain while still attached to the PA backbone, mainly through the action of LOX (PMID: 33329396 ).
Structure
Thumb
Synonyms
ValueSource
[(2R)-3-(Acetyloxy)-2-{[(3Z)-5-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxyoct-1-en-1-yl]cyclopentyl]pent-3-enoyl]oxy}propoxy]phosphonateGenerator
Chemical FormulaC23H39O11P
Average Molecular Weight522.528
Monoisotopic Molecular Weight522.222999074
IUPAC Name[(2R)-3-(acetyloxy)-2-{[(3Z)-5-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxyoct-1-en-1-yl]cyclopentyl]pent-3-enoyl]oxy}propoxy]phosphonic acid
Traditional Name(2R)-3-(acetyloxy)-2-{[(3Z)-5-[(1S,2R,3R,5S)-3,5-dihydroxy-2-[(1E,3R)-3-hydroxyoct-1-en-1-yl]cyclopentyl]pent-3-enoyl]oxy}propoxyphosphonic acid
CAS Registry NumberNot Available
SMILES
CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@H]1C\C=C/CC(=O)O[C@H](COC(C)=O)COP(O)(O)=O
InChI Identifier
InChI=1S/C23H39O11P/c1-3-4-5-8-17(25)11-12-20-19(21(26)13-22(20)27)9-6-7-10-23(28)34-18(14-32-16(2)24)15-33-35(29,30)31/h6-7,11-12,17-22,25-27H,3-5,8-10,13-15H2,1-2H3,(H2,29,30,31)/b7-6-,12-11+/t17-,18-,19+,20-,21+,22-/m1/s1
InChI KeySTFIURNMGJWLJB-FPOGUXASSA-N
Chemical Taxonomy
ClassificationNot classified
Ontology
Not Available
Physical Properties
StateNot Available
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
logP1.21ALOGPS
logP0.86ChemAxon
logS-4.1ALOGPS
pKa (Strongest Acidic)1.32ChemAxon
pKa (Strongest Basic)-1.6ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count8ChemAxon
Hydrogen Donor Count5ChemAxon
Polar Surface Area180.05 ŲChemAxon
Rotatable Bond Count18ChemAxon
Refractivity128.32 m³·mol⁻¹ChemAxon
Polarizability54.31 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
AllCCS[M+H]+225.40832859911
AllCCS[M+H-H2O]+223.84632859911
AllCCS[M+Na]+227.22832859911
AllCCS[M+NH4]+226.82632859911
AllCCS[M-H]-220.20532859911
AllCCS[M+Na-2H]-222.8232859911
AllCCS[M+HCOO]-225.84132859911
DeepCCS[M+H]+213.26630932474
DeepCCS[M-H]-211.44130932474
DeepCCS[M-2H]-244.68430932474
DeepCCS[M+Na]+218.93230932474

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
PA(2:0/5-iso PGF2VI)CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@H]1C\C=C/CC(=O)O[C@H](COC(C)=O)COP(O)(O)=O4408.3Standard polar33892256
PA(2:0/5-iso PGF2VI)CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@H]1C\C=C/CC(=O)O[C@H](COC(C)=O)COP(O)(O)=O3170.8Standard non polar33892256
PA(2:0/5-iso PGF2VI)CCCCC[C@@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@H]1C\C=C/CC(=O)O[C@H](COC(C)=O)COP(O)(O)=O3894.9Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
PA(2:0/5-iso PGF2VI),4TMS,isomer #1CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C3512.7Semi standard non polar33892256
PA(2:0/5-iso PGF2VI),4TMS,isomer #1CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C3162.7Standard non polar33892256
PA(2:0/5-iso PGF2VI),4TMS,isomer #1CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C4411.7Standard polar33892256
PA(2:0/5-iso PGF2VI),4TMS,isomer #2CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O)O[Si](C)(C)C3554.6Semi standard non polar33892256
PA(2:0/5-iso PGF2VI),4TMS,isomer #2CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O)O[Si](C)(C)C3238.7Standard non polar33892256
PA(2:0/5-iso PGF2VI),4TMS,isomer #2CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O)O[Si](C)(C)C4301.4Standard polar33892256
PA(2:0/5-iso PGF2VI),4TMS,isomer #3CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C3562.8Semi standard non polar33892256
PA(2:0/5-iso PGF2VI),4TMS,isomer #3CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C3210.6Standard non polar33892256
PA(2:0/5-iso PGF2VI),4TMS,isomer #3CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C4181.7Standard polar33892256
PA(2:0/5-iso PGF2VI),4TMS,isomer #4CCCCC[C@@H](O)/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C3541.1Semi standard non polar33892256
PA(2:0/5-iso PGF2VI),4TMS,isomer #4CCCCC[C@@H](O)/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C3207.1Standard non polar33892256
PA(2:0/5-iso PGF2VI),4TMS,isomer #4CCCCC[C@@H](O)/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C4325.2Standard polar33892256
PA(2:0/5-iso PGF2VI),5TMS,isomer #1CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C3523.7Semi standard non polar33892256
PA(2:0/5-iso PGF2VI),5TMS,isomer #1CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C3161.6Standard non polar33892256
PA(2:0/5-iso PGF2VI),5TMS,isomer #1CCCCC[C@H](/C=C/[C@@H]1[C@H](C/C=C\CC(=O)O[C@H](COC(C)=O)COP(=O)(O[Si](C)(C)C)O[Si](C)(C)C)[C@@H](O[Si](C)(C)C)C[C@H]1O[Si](C)(C)C)O[Si](C)(C)C3914.3Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_1_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_1_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_1_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_1_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_2_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_2_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_2_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_2_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_2_5) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_2_6) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_2_7) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_3_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_3_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_3_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_3_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_3_5) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_3_6) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TMS_3_7) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TBDMS_1_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TBDMS_1_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TBDMS_1_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TBDMS_1_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TBDMS_2_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TBDMS_2_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - PA(2:0/5-iso PGF2VI) GC-MS (TBDMS_2_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PA(2:0/5-iso PGF2VI) 10V, Positive-QTOFsplash10-0ab9-0000090000-a2871a049101ffb47db12021-09-28Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PA(2:0/5-iso PGF2VI) 20V, Positive-QTOFsplash10-00fr-0000590000-4c253254a521c1c4d54e2021-09-28Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PA(2:0/5-iso PGF2VI) 40V, Positive-QTOFsplash10-01ta-0300910000-d7a9cf06ae127ed76a712021-09-28Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PA(2:0/5-iso PGF2VI) 10V, Negative-QTOFsplash10-00di-0000090000-d3eda59a4b2c96a95bb82021-09-28Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PA(2:0/5-iso PGF2VI) 20V, Negative-QTOFsplash10-072a-6915670000-449d7d7fbf47ed5acf4c2021-09-28Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PA(2:0/5-iso PGF2VI) 40V, Negative-QTOFsplash10-056r-9215210000-85bfdeef032dcf5da8c32021-09-28Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PA(2:0/5-iso PGF2VI) 10V, Positive-QTOFsplash10-0002-0000090000-1ed2b73c7f0b5207a27d2021-09-28Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PA(2:0/5-iso PGF2VI) 20V, Positive-QTOFsplash10-0002-0000990000-16cfb6b7787a9ae8d1372021-09-28Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PA(2:0/5-iso PGF2VI) 40V, Positive-QTOFsplash10-00kk-0070890000-2987b702332fc1a2330d2021-09-28Wishart LabView Spectrum
Biological Properties
Cellular LocationsNot Available
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDNot Available
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem CompoundNot Available
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Hajeyah AA, Griffiths WJ, Wang Y, Finch AJ, O'Donnell VB: The Biosynthesis of Enzymatically Oxidized Lipids. Front Endocrinol (Lausanne). 2020 Nov 19;11:591819. doi: 10.3389/fendo.2020.591819. eCollection 2020. [PubMed:33329396 ]

Only showing the first 10 proteins. There are 61 proteins in total.

Enzymes

General function:
Involved in protein binding
Specific function:
May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).
Gene Name:
PLD2
Uniprot ID:
O14939
Molecular weight:
104656.485
General function:
Involved in diacylglycerol kinase activity
Specific function:
Phosphorylates diacylglycerol (DAG) to generate phosphatidic acid (PA). May regulate the activity of protein kinase C by controlling the balance between these two signaling lipids. Activated in the nucleus in response to alpha-thrombin and nerve growth factor. May be involved in cAMP- induced activation of NR5A1 and subsequent steroidogenic gene transcription by delivering PA as ligand for NR5A1. Acts synergistically with NR5A1 on CYP17 transcriptional activity
Gene Name:
DGKQ
Uniprot ID:
P52824
Molecular weight:
101154.0
General function:
Involved in diacylglycerol kinase activity
Specific function:
Reverses the normal flow of glycerolipid biosynthesis by phosphorylating diacylglycerol back to phosphatidic acid
Gene Name:
DGKG
Uniprot ID:
P49619
Molecular weight:
89095.3
General function:
Involved in catalytic activity
Specific function:
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.
Gene Name:
PPAP2C
Uniprot ID:
O43688
Molecular weight:
32573.435
General function:
Involved in diacylglycerol kinase activity
Specific function:
Upon cell stimulation converts the second messenger diacylglycerol into phosphatidate, initiating the resynthesis of phosphatidylinositols and attenuating protein kinase C activity
Gene Name:
DGKA
Uniprot ID:
P23743
Molecular weight:
82629.5
General function:
Involved in diacylglycerol kinase activity
Specific function:
Isoform 2 may be involved in cell growth and tumorigenesis. Involved in clathrin-dependent endocytosis
Gene Name:
DGKD
Uniprot ID:
Q16760
Molecular weight:
134524.2
General function:
Involved in catalytic activity
Specific function:
Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.
Gene Name:
PPAP2A
Uniprot ID:
O14494
Molecular weight:
32155.715
General function:
Involved in diacylglycerol kinase activity
Specific function:
Exhibits high phosphorylation activity for long-chain diacylglycerols
Gene Name:
DGKB
Uniprot ID:
Q9Y6T7
Molecular weight:
90594.7
General function:
Involved in diacylglycerol kinase activity
Specific function:
ATP + 1,2-diacylglycerol = ADP + 1,2-diacyl- sn-glycerol 3-phosphate
Gene Name:
DGKI
Uniprot ID:
O75912
Molecular weight:
116996.2
General function:
Involved in catalytic activity
Specific function:
Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.
Gene Name:
PPAP2B
Uniprot ID:
O14495
Molecular weight:
35115.61

Only showing the first 10 proteins. There are 61 proteins in total.