Hmdb loader

HMDBP00437 (Indoleamine 2,3-dioxygenase 1) Metabolite Associations

Displaying all 13 metabolite protein links
HMDB ID Name CAS NumberStructureFormula Average Mass
Monoisotopic Mass 		References
HMDB0000259Serotonin50-67-9ThumbC10H12N2O176.2151
176.094963016		Not Available
HMDB00004725-Hydroxy-L-tryptophan4350-09-8ThumbC11H12N2O3220.2246
220.08479226		Not Available
HMDB0000929L-Tryptophan73-22-3ThumbC11H12N2O2204.2252
204.089877638
  1. Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. [PubMed:11752352 ]
  2. Agaugue S, Perrin-Cocon L, Coutant F, Andre P, Lotteau V: 1-Methyl-tryptophan can interfere with TLR signaling in dendritic cells independently of IDO activity. J Immunol. 2006 Aug 15;177(4):2061-71. [PubMed:16887964 ]
  3. Fallarino F, Gizzi S, Mosci P, Grohmann U, Puccetti P: Tryptophan catabolism in IDO+ plasmacytoid dendritic cells. Curr Drug Metab. 2007 Apr;8(3):209-16. [PubMed:17430109 ]
  4. Cozzi A, Zignego AL, Carpendo R, Biagiotti T, Aldinucci A, Monti M, Giannini C, Rosselli M, Laffi G, Moroni F: Low serum tryptophan levels, reduced macrophage IDO activity and high frequency of psychopathology in HCV patients. J Viral Hepat. 2006 Jun;13(6):402-8. [PubMed:16842443 ]
  5. Grohmann U, Volpi C, Fallarino F, Bozza S, Bianchi R, Vacca C, Orabona C, Belladonna ML, Ayroldi E, Nocentini G, Boon L, Bistoni F, Fioretti MC, Romani L, Riccardi C, Puccetti P: Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy. Nat Med. 2007 May;13(5):579-86. Epub 2007 Apr 8. [PubMed:17417651 ]
  6. Zheng X, Koropatnick J, Li M, Zhang X, Ling F, Ren X, Hao X, Sun H, Vladau C, Franek JA, Feng B, Urquhart BL, Zhong R, Freeman DJ, Garcia B, Min WP: Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference. J Immunol. 2006 Oct 15;177(8):5639-46. [PubMed:17015752 ]
  7. Rafice SA, Chauhan N, Efimov I, Basran J, Raven EL: Oxidation of L-tryptophan in biology: a comparison between tryptophan 2,3-dioxygenase and indoleamine 2,3-dioxygenase. Biochem Soc Trans. 2009 Apr;37(Pt 2):408-12. doi: 10.1042/BST0370408. [PubMed:19290871 ]
HMDB0001200N'-Formylkynurenine1022-31-7ThumbC11H12N2O4236.224
236.079706882		Not Available
HMDB0001377Oxygen7782-44-7ThumbO231.9988
31.989829244		Not Available
HMDB0001389Melatonin73-31-4ThumbC13H16N2O2232.2783
232.121177766
  1. Ferry G, Ubeaud C, Lambert PH, Bertin S, Coge F, Chomarat P, Delagrange P, Serkiz B, Bouchet JP, Truscott RJ, Boutin JA: Molecular evidence that melatonin is enzymatically oxidized in a different manner than tryptophan: investigations with both indoleamine 2,3-dioxygenase and myeloperoxidase. Biochem J. 2005 May 15;388(Pt 1):205-15. [PubMed:15636586 ]
HMDB0003178Heme14875-96-8ThumbC34H32FeN4O4616.487
616.177297665		Not Available
HMDB00040865-Hydroxy-N-formylkynurenineThumbC11H12N2O5252.2234
252.074621504		Not Available
HMDB0004259Acetyl-N-formyl-5-methoxykynurenamine52450-38-1ThumbC13H16N2O4264.2771
264.11100701		Not Available
HMDB0012948Formyl-5-hydroxykynurenamine958733-17-0ThumbC10H12N2O3208.2139
208.08479226		Not Available
HMDB0013609D-Tryptophan153-94-6ThumbC11H12N2O2204.2252
204.089877638		Not Available
HMDB0060485L-FormylkynurenineThumbC11H12N2O4236.224
236.079706882		Not Available
HMDB0250769D-KynurenineThumbC10H12N2O3208.2139
208.08479226		Not Available
Displaying all 13 metabolite protein links