Showing metabocard for Heme (HMDB0003178)

General function:

Involved in 5-aminolevulinate synthase activity

Specific function:

Not Available

Gene Name:

ALAS2

Uniprot ID:

P22557

Molecular weight:

64632.86

General function:

Involved in 5-aminolevulinate synthase activity

Specific function:

Not Available

Gene Name:

ALAS1

Uniprot ID:

P13196

Molecular weight:

70580.325

General function:

Involved in succinate dehydrogenase activity

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).

Gene Name:

SDHC

Uniprot ID:

Q99643

Molecular weight:

16650.185

General function:

Involved in oxidoreductase activity

Specific function:

Not Available

Gene Name:

AOX1

Uniprot ID:

Q06278

Molecular weight:

147916.735

General function:

Involved in heme oxygenase (decyclizing) activity

Specific function:

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Heme oxygenase 2 could be implicated in the production of carbon monoxide in brain where it could act as a neurotransmitter.

Gene Name:

HMOX2

Uniprot ID:

P30519

Molecular weight:

36032.615

Reactions

General function:

Involved in iron ion binding

Specific function:

Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) (By similarity).

Gene Name:

SDHD

Uniprot ID:

O14521

Molecular weight:

17042.82

General function:

Involved in oxidoreductase activity

Specific function:

This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5.

Gene Name:

POR

Uniprot ID:

P16435

Molecular weight:

77047.575

General function:

Involved in heme oxygenase (decyclizing) activity

Specific function:

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.

Gene Name:

HMOX1

Uniprot ID:

P09601

Molecular weight:

32818.345

Reactions

General function:

Involved in uroporphyrinogen decarboxylase activity

Specific function:

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.

Gene Name:

UROD

Uniprot ID:

P06132

Molecular weight:

40786.58

General function:

Involved in coproporphyrinogen oxidase activity

Specific function:

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III.

Gene Name:

CPOX

Uniprot ID:

P36551

Molecular weight:

50151.605