Search Results for metabolites
Searching metabolites for histamine returned 108 results.
HMDB0015670
147084-10-4
Blood Urine
2-(1-methylpiperidin-4-ylidene)-4,7-diazatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3,5,10,12-pentaene-6-carbaldehyde
Matched description: … the release of histamine from mast cells. ... It is a H1 histamine receptor antagonist indicated for the prevention of itching associated with allergic ... This drug was approved in July 2010.Alcaftadine is a H1 histamine receptor antagonist and inhibitor of …
HMDB0013253
673-49-4
Blood Feces Urine
N-[2-(1H-imidazol-5-yl)ethyl]acetamide
Matched synonyms: … N-Omega-acetyl-histamine …
Matched description: … It is generated from Histamine via the enzyme Transferases (EC 2.3.1.-). ... Histamine is an amine derived by enzymatic decarboxylation of histidine. …
Matched description: … It is generated from Histamine via the enzyme Transferases (EC 2.3.1.-). ... Histamine is an amine derived by enzymatic decarboxylation of histidine. …
HMDB0015107
58581-89-8
Blood Urine
4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-1,2-dihydrophthalazin-1-one
Matched description: … as a nasal spray for hay fever and as eye drops for allergic conjunctivitis.Azelastine competes with histamine ... for the H1-receptor sites on effector cells and acts as an antagonist by inhibiting the release of histamine …
HMDB0240216
118288-08-7
2-[(furan-2-yl)methanesulfinyl]-N-[(2Z)-4-({4-[(piperidin-1-yl)methyl]pyridin-2-yl}oxy)but-2-en-1-yl]acetamide
Matched description: … Lafutidine is a histamine H2-receptor antagonist that inhibits histamine-stimulated gastric acid secretion …
HMDB0015644
5638-76-6
Blood Urine
methyl[2-(pyridin-2-yl)ethyl]amine
Matched description: … Betahistine also acts as a histamine H3-receptor antagonist which causes an increased output of histamine ... H1-agonist with 0.07 times the activity of histamine. ... It is also commonly used for patients with balance disorders.Betahistine primarily acts as a histamine …
HMDB0015307
82-92-8
Blood Urine
1-(diphenylmethyl)-4-methylpiperazine
Matched description: … Hence the action of cyclizine which acts to block the histamine receptors in the vomiting centre and ... The vomiting centre possesses neurons which are rich in muscarinic cholinergic and histamine containing ... It is a histamine H1 antagonist given by mouth or parenterally for the control of postoperative and drug-induced …
HMDB0015056
34580-14-8
Blood Urine
2-(1-methylpiperidin-4-ylidene)-6-thiatricyclo[8.4.0.0³,⁷]tetradeca-1(14),3(7),4,10,12-pentaen-8-one
Matched description: … It is a cycloheptathiophene blocker of histamine H1 receptors and release of inflammatory mediators. ... [PubChem]Ketotifen is a relatively selective, non-competitive histamine antagonist (H1-receptor) and ... Ketotifen inhibits of the release of allergic mediators such as histamine, leukotrienes C4 and D4(SRS-A …
HMDB0014886
486-16-8
Blood Urine
{2-[(4-chlorophenyl)(pyridin-2-yl)methoxy]ethyl}dimethylamine
Matched description: … brought on by histamine HA-receptor binding. ... Carbinoxamine is a first generation antihistamine that competes with free histamine for binding at HA-receptor ... This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms …
HMDB0015204
29216-28-2
Blood Urine
10-{1-azabicyclo[2.2.2]octan-3-ylmethyl}-10H-phenothiazine
Matched description: … Mequitazine is a histamine H1 antagonist (antihistamine). ... It competes with histamine for the normal H1-receptor sites on effector cells of the gastrointestinal …
HMDB0014697
68-88-2
Blood Urine
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)ethan-1-ol
Matched description: … , and histamine-mediated pruritus. ... A histamine H1 receptor antagonist that is effective in the treatment of chronic urticaria, dermatitis …
HMDB0005032
83881-51-0
Blood Urine
2-(2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethoxy)acetic acid
Matched description: … It is a second-generation H1-receptor antagonist antihistamine and works by blocking H1 histamine receptors ... A potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis ... It is a second-generation H1-receptor antagonist antihistamine and works by blocking H1 histamine receptors …
HMDB0001930
82530-72-1
Blood Urine
dimethyl[(5-{[(2-{[(E)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}furan-2-yl)methyl]amine
Matched description: … Ranitidine (CAS: 66357-35-5) is a non-imidazole blocker of histamine receptors that mediate gastric secretion ... Ranitidine is a histamine H2-receptor antagonist that inhibits stomach acid production and is commonly …
HMDB0014723
76963-41-2
Blood Urine
dimethyl[(4-{[(2-{[(E)-1-(methylamino)-2-nitroethenyl]amino}ethyl)sulfanyl]methyl}-1,3-thiazol-2-yl)methyl]amine
Matched description: … It is a histamine H2 receptor antagonist with low toxicity that inhibits gastric acid secretion. ... [PubChem]Nizatidine competes with histamine for binding at the H2-receptors on the gastric …
HMDB0015202
60-87-7
Blood Urine
dimethyl[1-(10H-phenothiazin-10-yl)propan-2-yl]amine
Matched description: … It is a phenothiazine derivative with histamine H1-blocking, antimuscarinic, and sedative properties. ... [PubChem]Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor …
HMDB0002229
7170-38-9
Blood Urine
3-phenoxypropanoic acid
Matched description: … 3-Phenoxypropionic acid is a histamine H3 (H3 receptors controls histaminergic neuron activity) receptor …
HMDB0013633
108437-64-5
Blood
(5Z,8Z,10E,14Z)-12-oxoicosa-5,8,10,14-tetraenoic acid
Matched description: … lipid stores in nervous tissue, labeled with [3H]arachidonic acid upon stimulation by application of histamine ... abdominal ganglion, applications of 12-KETE elicit changes in membrane potential similar to those evoked by histamine …
HMDB0000898
501-75-7
Blood Cerebrospinal Fluid (CSF) Feces Saliva Urine
2-(1-methyl-1H-imidazol-4-yl)ethan-1-amine
Matched synonyms: … 1-Methyl-4-histamine …
Matched description: … ; which is mediated by the enzyme histamine N-methyltransferase. ... particular, S-adenosylhomocysteine and 1-methylhistamine can be biosynthesized from S-adenosylmethionine and histamine …
Matched description: … ; which is mediated by the enzyme histamine N-methyltransferase. ... particular, S-adenosylhomocysteine and 1-methylhistamine can be biosynthesized from S-adenosylmethionine and histamine …
HMDB0015695
78628-28-1
Blood Urine
({3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}carbamoyl)methyl acetate
Matched description: … They accomplish this by two mechanisms: histamine released by ECL cells in the stomach is blocked from ... approved in South Africa under the tradename Roxit.The H2 antagonists are competitive inhibitors of histamine …
HMDB0003920
130-86-9
15-methyl-7,9,19,21-tetraoxa-15-azapentacyclo[15.7.0.0⁴,¹².0⁶,¹⁰.0¹⁸,²²]tetracosa-1(17),4(12),5,10,18(22),23-hexaen-3-one
Matched description: … It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an opioid analgesic …
HMDB0005030
83799-24-0
Blood Feces Urine
2-(4-{1-hydroxy-4-[4-(hydroxydiphenylmethyl)piperidin-1-yl]butyl}phenyl)-2-methylpropanoic acid
Matched description: … does not readily enter the brain from the blood, and so causes less drowsiness than first generation histamine ... does not readily enter the brain from the blood, and so causes less drowsiness than first-generation histamine-receptor …
HMDB0015553
13461-01-3
Blood Urine
1-{10-[2-(dimethylamino)propyl]-10H-phenothiazin-2-yl}ethan-1-one
Matched description: … Aceprometazine (INN) is a prescription drug with neuroleptic and anti-histamine properties. …
HMDB0014498
82-95-1
Blood Urine
1-[(4-tert-butylphenyl)methyl]-4-[(4-chlorophenyl)(phenyl)methyl]piperazine
Matched description: … The vomiting centre possesses neurons which are rich in muscarinic cholinergic and histamine containing ... Hence the action of buclizine which acts to block the histamine receptors in the vomiting centre and …
HMDB0004988
4200-48-0
Blood Cerebrospinal Fluid (CSF) Feces Urine
2-(1-methyl-1H-imidazol-5-yl)acetic acid
Matched description: … Although pi-Methylimidazoleacetic acid's isomer (1,4-Methylimidazoleacetic acid) is a known metabolite of Histamine …
HMDB0014935
59-98-3
Blood Urine
2-benzyl-4,5-dihydro-1H-imidazole
Matched description: … Tolazoline can interact to some degree with histamine, adrenergic, and cholinergic receptors, but the …
Blood Urine
[(E)-1-(methylamino)-2-nitroethenyl]({2-[({2-[(methylamino)methyl]-1,3-thiazol-4-yl}methyl)sulfanyl]ethyl})amine
Matched description: … Nizatidine is a histamine H2-receptor antagonist that inhibits stomach acid production, and commonly …