Showing metabocard for Deoxycytidine (HMDB0000014)

General function:

Involved in hydrolase activity

Specific function:

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.

Gene Name:

NT5E

Uniprot ID:

P21589

Molecular weight:

57948.125

Reactions

General function:

Involved in nucleotide binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).

Gene Name:

NT5C1B

Uniprot ID:

Q96P26

Molecular weight:

68803.055

Reactions

General function:

Involved in nucleotide binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.

Gene Name:

NT5C1A

Uniprot ID:

Q9BXI3

Molecular weight:

41020.145

Reactions

General function:

Involved in metal ion binding

Specific function:

Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.

Gene Name:

NT5C

Uniprot ID:

Q8TCD5

Molecular weight:

Not Available

Reactions

General function:

Involved in ATP binding

Specific function:

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Gene Name:

DCK

Uniprot ID:

P27707

Molecular weight:

30518.315

Reactions

References

1. Giovannetti E, Mey V, Loni L, Nannizzi S, Barsanti G, Savarino G, Ricciardi S, Del Tacca M, Danesi R: Cytotoxic activity of gemcitabine and correlation with expression profile of drug-related genes in human lymphoid cells. Pharmacol Res. 2007 Apr;55(4):343-9. Epub 2007 Jan 16. [PubMed:17296311 ]

General function:

Involved in phosphatase activity

Specific function:

Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.

Gene Name:

NT5M

Uniprot ID:

Q9NPB1

Molecular weight:

Not Available

Reactions

General function:

Involved in zinc ion binding

Specific function:

Not Available

Gene Name:

AID

Uniprot ID:

Q546Y9

Molecular weight:

23953.3

General function:

Involved in magnesium ion binding

Specific function:

Can act both as nucleotidase and as phosphotransferase.

Gene Name:

NT5C3

Uniprot ID:

Q9H0P0

Molecular weight:

33914.91

Reactions

General function:

Involved in 5'-nucleotidase activity

Specific function:

May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.

Gene Name:

NT5C2

Uniprot ID:

P49902

Molecular weight:

64969.2

Reactions

General function:

Involved in zinc ion binding

Specific function:

This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.

Gene Name:

CDA

Uniprot ID:

P32320

Molecular weight:

16184.545

Reactions