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Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References enzymes (12) Show 12 proteins XML

Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2005-11-16 15:48:42 UTC

Update Date

2021-09-14 15:48:16 UTC

HMDB ID

HMDB0000014

Secondary Accession Numbers

HMDB00014

Metabolite Identification

Common Name

Deoxycytidine

Description

Deoxycytidine, also known as dC, belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleosides. Pyrimidine 2'-deoxyribonucleosides are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2. Deoxycytidine is also classified as a deoxyribonucleoside, a component of deoxyribonucleic acid (DNA). Deoxycytidine is similar to the ribonucleoside cytidine, but with one hydroxyl group removed from the 2' position. Deoxycytidine exists in all living species, ranging from bacteria to plants to humans. Degradation of DNA through apoptosis or cell death produces deoxycytidine. Within humans, deoxycytidine participates in a number of enzymatic reactions. In particular, deoxycytidine can be biosynthesized from dCMP through the action of the enzyme cytosolic purine 5'-nucleotidase. In addition, deoxycytidine can be converted into dCMP; which is mediated by the enzyme uridine-cytidine kinase-like 1. Deoxycytidine can be phosphorylated at the C-5 position by the enzyme deoxycytidine kinase to produce deoxycytidine monophosphate (dCMP), and to a lesser extent, deoxycytidine diphosphate (dCDP), and deoxycytidine triphosphate (dCTP). Deoxycytidine can also be phosphorylated by thymidine kinase 2 (TK2). Deoxycytidine can potentially be used for the treatment of the metabolic disorder known as thymidine kinase 2 deficiency (TK2 deficiency). TK2 deficiency has three disease subtypes: i) infantile-onset myopathy with rapid progression to early death ii) childhood-onset myopathy, which resembles spinal muscular atrophy (SMA) type III, begins between ages 1 and 12 years with progression to loss of ambulation within few years and iii) late-onset myopathy starting at age 12 year or later with moderate to severe myopathy manifesting as either isolated chronic progressive external ophthalmoplegia (CPEO) or a generalized myopathy with CPEO plus facial and limb weakness, gradual progression, and, in some cases, respiratory failure and loss of ability to walk in adulthood (PMID: 28318037 ). In mouse models of TK2, dC was shown to delay disease onset, prolong life span and restore mtDNA copy number as well as respiratory chain enzyme activities (PMID: 28318037 ).

Structure

MOL SDF 3D SDF PDB 3D PDB SMILES InChI


  Mrv1652309032023492D          

 16 17  0  0  1  0            999 V2000
   -0.2649   -0.0103    0.0000 C   0  0  2  0  0  0  0  0  0  0  0  0
    0.5196    0.2409    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9396    0.4989    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
   -0.5092   -0.7745    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    1.1186   -0.3200    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.7057    1.0359    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6037    0.0034    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
   -1.3457   -0.7745    0.0000 C   0  0  1  0  0  0  0  0  0  0  0  0
    1.9102   -0.0860    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
    0.9362   -1.1288    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.4936    1.2803    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.3920    0.2546    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -1.6003   -1.5796    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.0891    0.7125    0.0000 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0009   -0.2993    0.0000 O   0  0  0  0  0  0  0  0  0  0  0  0
    2.8874    0.9465    0.0000 N   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  1  0  0  0
  1  3  1  0  0  0  0
  1  4  1  0  0  0  0
  2  5  1  0  0  0  0
  2  6  1  0  0  0  0
  3  7  1  0  0  0  0
  4  8  1  0  0  0  0
  5  9  1  0  0  0  0
  5 10  2  0  0  0  0
  6 11  2  0  0  0  0
  7 12  1  1  0  0  0
  8 13  1  6  0  0  0
  9 14  2  0  0  0  0
 12 15  1  0  0  0  0
 14 16  1  0  0  0  0
  7  8  1  0  0  0  0
 11 14  1  0  0  0  0
M  END
> <DATABASE_ID>
HMDB0000014

> <DATABASE_NAME>
hmdb

> <SMILES>
NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](CO)O1

> <INCHI_IDENTIFIER>
InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1

> <INCHI_KEY>
CKTSBUTUHBMZGZ-SHYZEUOFSA-N

> <FORMULA>
C9H13N3O4

> <MOLECULAR_WEIGHT>
227.2172

> <EXACT_MASS>
227.090605919

> <JCHEM_ACCEPTOR_COUNT>
6

> <JCHEM_ATOM_COUNT>
29

> <JCHEM_AVERAGE_POLARIZABILITY>
21.64578911898849

> <JCHEM_BIOAVAILABILITY>
1

> <JCHEM_DONOR_COUNT>
3

> <JCHEM_FORMAL_CHARGE>
0

> <JCHEM_GHOSE_FILTER>
0

> <JCHEM_IUPAC>
4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one

> <ALOGPS_LOGP>
-1.93

> <JCHEM_LOGP>
-1.8968792213333328

> <ALOGPS_LOGS>
-1.16

> <JCHEM_MDDR_LIKE_RULE>
0

> <JCHEM_NUMBER_OF_RINGS>
2

> <JCHEM_PHYSIOLOGICAL_CHARGE>
0

> <JCHEM_PKA>
14.78753514288664

> <JCHEM_PKA_STRONGEST_ACIDIC>
13.894899521324458

> <JCHEM_PKA_STRONGEST_BASIC>
0.3081753362314522

> <JCHEM_POLAR_SURFACE_AREA>
108.38

> <JCHEM_REFRACTIVITY>
53.0341

> <JCHEM_ROTATABLE_BOND_COUNT>
2

> <JCHEM_RULE_OF_FIVE>
1

> <ALOGPS_SOLUBILITY>
1.59e+01 g/l

> <JCHEM_TRADITIONAL_IUPAC>
2'-deoxycytidine

> <JCHEM_VEBER_RULE>
0

$$$$

https://cactus.nci.nih.gov/chemical/structure/NC1=NC(=O)N(C=C1)%5BC@H%5D1C%5B...
 OpenBabel09142113213D
Jmol version 14.31.45  2021-07-21 05:08 EXTRACT: ({0:28})
 29 30  0  0  0  0  0  0  0  0999 V2000
    4.8304    0.5527    0.5852 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5443    0.2654    0.1905 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5276    0.4958    1.0109 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2783    0.2220    0.6390 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3603    0.4432    1.4113 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0121   -0.2943   -0.5748 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0237   -0.5485   -1.4517 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2987   -0.2701   -1.0906 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3724   -0.5850   -0.9554 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4118   -0.8995   -1.9983 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9422   -1.6954   -0.0514 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1781   -1.0444    0.6160 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.9315   -0.6692    1.6092 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2687   -1.9658    0.6779 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4936    0.1229   -0.3538 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.0613   -0.2346   -1.2128 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2574    1.2333    0.3705 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6367    2.2412   -0.5689 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1870    0.5841   -0.7664 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9959    0.9248    1.4656 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5722    0.3795   -0.0153 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8104   -0.9631   -2.4258 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1157   -0.4635   -1.7699 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2404   -2.5575   -0.6479 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2106   -1.9865    0.7025 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0851   -2.7579    1.2013 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1503    0.8161    0.8361 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6194    1.6728    1.1371 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1260    2.9784   -0.1787 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1 20  1  0  0  0  0
  1 21  1  0  0  0  0
  2  3  2  0  0  0  0
  2  8  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  9  1  0  0  0  0
  7  8  2  0  0  0  0
  7 22  1  0  0  0  0
  8 23  1  0  0  0  0
  9 10  1  6  0  0  0
  9 11  1  0  0  0  0
  9 19  1  0  0  0  0
 11 12  1  0  0  0  0
 11 24  1  0  0  0  0
 11 25  1  0  0  0  0
 12 13  1  1  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 26  1  0  0  0  0
 15 16  1  6  0  0  0
 15 17  1  0  0  0  0
 15 19  1  0  0  0  0
 17 18  1  0  0  0  0
 17 27  1  0  0  0  0
 17 28  1  0  0  0  0
 18 29  1  0  0  0  0
M  END
$$$$

HEADER    PROTEIN                                 03-SEP-20   NONE
TITLE     NULL                                                        
COMPND    NULL                                                        
SOURCE    NULL                                                        
KEYWDS    NULL                                                        
EXPDTA    NULL                                                        
AUTHOR    Marvin                                                      
REVDAT   1   03-SEP-20         0                                  
HETATM    1  C   UNK     0      -0.495  -0.019   0.000  0.00  0.00           C+0
HETATM    2  N   UNK     0       0.970   0.450   0.000  0.00  0.00           N+0
HETATM    3  O   UNK     0      -1.754   0.931   0.000  0.00  0.00           O+0
HETATM    4  C   UNK     0      -0.951  -1.446   0.000  0.00  0.00           C+0
HETATM    5  C   UNK     0       2.088  -0.597   0.000  0.00  0.00           C+0
HETATM    6  C   UNK     0       1.317   1.934   0.000  0.00  0.00           C+0
HETATM    7  C   UNK     0      -2.994   0.006   0.000  0.00  0.00           C+0
HETATM    8  C   UNK     0      -2.512  -1.446   0.000  0.00  0.00           C+0
HETATM    9  N   UNK     0       3.566  -0.161   0.000  0.00  0.00           N+0
HETATM   10  O   UNK     0       1.748  -2.107   0.000  0.00  0.00           O+0
HETATM   11  C   UNK     0       2.788   2.390   0.000  0.00  0.00           C+0
HETATM   12  C   UNK     0      -4.465   0.475   0.000  0.00  0.00           C+0
HETATM   13  O   UNK     0      -2.987  -2.949   0.000  0.00  0.00           O+0
HETATM   14  C   UNK     0       3.900   1.330   0.000  0.00  0.00           C+0
HETATM   15  O   UNK     0      -5.602  -0.559   0.000  0.00  0.00           O+0
HETATM   16  N   UNK     0       5.390   1.767   0.000  0.00  0.00           N+0
CONECT    1    2    3    4                                                  
CONECT    2    1    5    6                                                  
CONECT    3    1    7                                                       
CONECT    4    1    8                                                       
CONECT    5    2    9   10                                                  
CONECT    6    2   11                                                       
CONECT    7    3   12    8                                                  
CONECT    8    4   13    7                                                  
CONECT    9    5   14                                                       
CONECT   10    5                                                            
CONECT   11    6   14                                                       
CONECT   12    7   15                                                       
CONECT   13    8                                                            
CONECT   14    9   16   11                                                  
CONECT   15   12                                                            
CONECT   16   14                                                            
MASTER        0    0    0    0    0    0    0    0   16    0   34    0
END

COMPND    https://cactus.nci.nih.gov/chemical/structure/NC1=NC(=O)N(C=C1)%5BC@H%5D1C%5B... 
AUTHOR    GENERATED BY OPEN BABEL 3.1.0
ATOM      1  N4    C A   1       4.830   0.553   0.585  1.00  0.00           N  
ATOM      2  C4    C A   1       3.544   0.265   0.191  1.00  0.00           C  
ATOM      3  N3    C A   1       2.528   0.496   1.011  1.00  0.00           N  
ATOM      4  C2    C A   1       1.278   0.222   0.639  1.00  0.00           C  
ATOM      5  O2    C A   1       0.360   0.443   1.411  1.00  0.00           O  
ATOM      6  N1    C A   1       1.012  -0.294  -0.575  1.00  0.00           N  
ATOM      7  C6    C A   1       2.024  -0.548  -1.452  1.00  0.00           C  
ATOM      8  C5    C A   1       3.299  -0.270  -1.091  1.00  0.00           C  
ATOM      9  C1*   C A   1      -0.372  -0.585  -0.955  1.00  0.00           C  
ATOM     10  H1*   C A   1      -0.412  -0.899  -1.998  1.00  0.00           H  
ATOM     11  C2*   C A   1      -0.942  -1.695  -0.051  1.00  0.00           C  
ATOM     12  C3*   C A   1      -2.178  -1.044   0.616  1.00  0.00           C  
ATOM     13  H3*   C A   1      -1.931  -0.669   1.609  1.00  0.00           H  
ATOM     14  O3*   C A   1      -3.269  -1.966   0.678  1.00  0.00           O  
ATOM     15  C4*   C A   1      -2.494   0.123  -0.354  1.00  0.00           C  
ATOM     16  H4*   C A   1      -3.061  -0.235  -1.213  1.00  0.00           H  
ATOM     17  C5*   C A   1      -3.257   1.233   0.370  1.00  0.00           C  
ATOM     18  O5*   C A   1      -3.637   2.241  -0.569  1.00  0.00           O  
ATOM     19  O4*   C A   1      -1.187   0.584  -0.766  1.00  0.00           O  
ATOM     20  H41   C A   1       4.996   0.925   1.466  1.00  0.00           H  
ATOM     21  H42   C A   1       5.572   0.380  -0.015  1.00  0.00           H  
ATOM     22  H6    C A   1       1.810  -0.963  -2.426  1.00  0.00           H  
ATOM     23  H5    C A   1       4.116  -0.464  -1.770  1.00  0.00           H  
ATOM     24 H2*1   C A   1      -1.240  -2.558  -0.648  1.00  0.00           H  
ATOM     25 H2*2   C A   1      -0.211  -1.986   0.703  1.00  0.00           H  
ATOM     26  H3*   C A   1      -3.085  -2.758   1.201  1.00  0.00           H  
ATOM     27 H5*1   C A   1      -4.150   0.816   0.836  1.00  0.00           H  
ATOM     28 H5*2   C A   1      -2.619   1.673   1.137  1.00  0.00           H  
ATOM     29  H5*   C A   1      -4.126   2.978  -0.179  1.00  0.00           H  
CONECT    1    2   20   21                                            
CONECT    2    1    3    3    8                                       
CONECT    3    2    2    4                                            
CONECT    4    3    5    5    6                                       
CONECT    5    4    4                                                 
CONECT    6    4    7    9                                            
CONECT    7    6    8    8   22                                       
CONECT    8    7    7    2   23                                       
CONECT    9    6   10   11   19                                       
CONECT   10    9                                                      
CONECT   11    9   12   24   25                                       
CONECT   12   11   13   14   15                                       
CONECT   13   12                                                      
CONECT   14   12   26                                                 
CONECT   15   12   16   17   19                                       
CONECT   16   15                                                      
CONECT   17   15   18   27   28                                       
CONECT   18   17   29                                                 
CONECT   19   15    9                                                 
CONECT   20    1                                                      
CONECT   21    1                                                      
CONECT   22    7                                                      
CONECT   23    8                                                      
CONECT   24   11                                                      
CONECT   25   11                                                      
CONECT   26   14                                                      
CONECT   27   17                                                      
CONECT   28   17                                                      
CONECT   29   18                                                      
MASTER        0    0    0    0    0    0    0    0   29    0   29    0
END

https://cactus.nci.nih.gov/chemical/structure/NC1=NC(=O)N(C=C1)%5BC@H%5D1C%5B...
 OpenBabel09142113213D
Jmol version 14.31.45  2021-07-21 05:08 EXTRACT: ({0:28})
 29 30  0  0  0  0  0  0  0  0999 V2000
    4.8304    0.5527    0.5852 N   0  0  0  0  0  0  0  0  0  0  0  0
    3.5443    0.2654    0.1905 C   0  0  0  0  0  0  0  0  0  0  0  0
    2.5276    0.4958    1.0109 N   0  0  0  0  0  0  0  0  0  0  0  0
    1.2783    0.2220    0.6390 C   0  0  0  0  0  0  0  0  0  0  0  0
    0.3603    0.4432    1.4113 O   0  0  0  0  0  0  0  0  0  0  0  0
    1.0121   -0.2943   -0.5748 N   0  0  0  0  0  0  0  0  0  0  0  0
    2.0237   -0.5485   -1.4517 C   0  0  0  0  0  0  0  0  0  0  0  0
    3.2987   -0.2701   -1.0906 C   0  0  0  0  0  0  0  0  0  0  0  0
   -0.3724   -0.5850   -0.9554 C   0  0  1  0  0  0  0  0  0  0  0  0
   -0.4118   -0.8995   -1.9983 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.9422   -1.6954   -0.0514 C   0  0  0  0  0  0  0  0  0  0  0  0
   -2.1781   -1.0444    0.6160 C   0  0  2  0  0  0  0  0  0  0  0  0
   -1.9315   -0.6692    1.6092 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2687   -1.9658    0.6779 O   0  0  0  0  0  0  0  0  0  0  0  0
   -2.4936    0.1229   -0.3538 C   0  0  1  0  0  0  0  0  0  0  0  0
   -3.0613   -0.2346   -1.2128 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.2574    1.2333    0.3705 C   0  0  0  0  0  0  0  0  0  0  0  0
   -3.6367    2.2412   -0.5689 O   0  0  0  0  0  0  0  0  0  0  0  0
   -1.1870    0.5841   -0.7664 O   0  0  0  0  0  0  0  0  0  0  0  0
    4.9959    0.9248    1.4656 H   0  0  0  0  0  0  0  0  0  0  0  0
    5.5722    0.3795   -0.0153 H   0  0  0  0  0  0  0  0  0  0  0  0
    1.8104   -0.9631   -2.4258 H   0  0  0  0  0  0  0  0  0  0  0  0
    4.1157   -0.4635   -1.7699 H   0  0  0  0  0  0  0  0  0  0  0  0
   -1.2404   -2.5575   -0.6479 H   0  0  0  0  0  0  0  0  0  0  0  0
   -0.2106   -1.9865    0.7025 H   0  0  0  0  0  0  0  0  0  0  0  0
   -3.0851   -2.7579    1.2013 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1503    0.8161    0.8361 H   0  0  0  0  0  0  0  0  0  0  0  0
   -2.6194    1.6728    1.1371 H   0  0  0  0  0  0  0  0  0  0  0  0
   -4.1260    2.9784   -0.1787 H   0  0  0  0  0  0  0  0  0  0  0  0
  1  2  1  0  0  0  0
  1 20  1  0  0  0  0
  1 21  1  0  0  0  0
  2  3  2  0  0  0  0
  2  8  1  0  0  0  0
  3  4  1  0  0  0  0
  4  5  2  0  0  0  0
  4  6  1  0  0  0  0
  6  7  1  0  0  0  0
  6  9  1  0  0  0  0
  7  8  2  0  0  0  0
  7 22  1  0  0  0  0
  8 23  1  0  0  0  0
  9 10  1  6  0  0  0
  9 11  1  0  0  0  0
  9 19  1  0  0  0  0
 11 12  1  0  0  0  0
 11 24  1  0  0  0  0
 11 25  1  0  0  0  0
 12 13  1  1  0  0  0
 12 14  1  0  0  0  0
 12 15  1  0  0  0  0
 14 26  1  0  0  0  0
 15 16  1  6  0  0  0
 15 17  1  0  0  0  0
 15 19  1  0  0  0  0
 17 18  1  0  0  0  0
 17 27  1  0  0  0  0
 17 28  1  0  0  0  0
 18 29  1  0  0  0  0
M  END
$$$$

View in JSmol View Stereo Labels

Synonyms

Value	Source
4-Amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrimidin-2(1H)-one	ChEBI
dC	ChEBI
DCYD	ChEBI
2'-Deoxycytidine	Kegg
1-(2-Deoxy-b-D-ribofuranosyl)cytosine	HMDB
1-(2-Deoxy-beta-D-erythro-pentofuranosyl)-cytosine	HMDB
1-(2-Deoxy-beta-D-ribofuranosyl)cytosine	HMDB
1-(2-Deoxy-beta-delta-erythro-pentofuranosyl)-cytosine	HMDB
1-(2-Deoxy-beta-delta-ribofuranosyl)cytosine	HMDB
2-Deoxy-cytidine	HMDB
4-Amino-1-(2-deoxy-b-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone	HMDB
4-Amino-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-2(1H)-pyrimidinone	HMDB
4-Amino-1-(2-deoxy-beta-delta-erythro-pentofuranosyl)-2(1H)-pyrimidinone	HMDB
Cytosine deoxyribonucleoside	HMDB
Cytosine deoxyriboside	HMDB
Deoxy-cytidine	HMDB
Deoxyribose cytidine	HMDB
Desoxycytidine	HMDB
Deoxyribonucleoside, cytosine	HMDB
Deoxyriboside, cytosine	HMDB
Deoxycytidine	ChEBI

Chemical Formula

C₉H₁₃N₃O₄

Average Molecular Weight

227.2172

Monoisotopic Molecular Weight

227.090605919

IUPAC Name

4-amino-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,2-dihydropyrimidin-2-one

Traditional Name

2'-deoxycytidine

CAS Registry Number

951-77-9

SMILES

NC1=NC(=O)N(C=C1)[C@H]1C[C@H](O)[C@@H](CO)O1

InChI Identifier

InChI=1S/C9H13N3O4/c10-7-1-2-12(9(15)11-7)8-3-5(14)6(4-13)16-8/h1-2,5-6,8,13-14H,3-4H2,(H2,10,11,15)/t5-,6+,8+/m0/s1

InChI Key

CKTSBUTUHBMZGZ-SHYZEUOFSA-N

Chemical Taxonomy

Description

Belongs to the class of organic compounds known as pyrimidine 2'-deoxyribonucleosides. Pyrimidine 2'-deoxyribonucleosides are compounds consisting of a pyrimidine linked to a ribose which lacks a hydroxyl group at position 2.

Kingdom

Organic compounds

Super Class

Nucleosides, nucleotides, and analogues

Class

Pyrimidine nucleosides

Sub Class

Pyrimidine 2'-deoxyribonucleosides

Direct Parent

Pyrimidine 2'-deoxyribonucleosides

Alternative Parents

Substituents

Pyrimidine 2'-deoxyribonucleoside
Aminopyrimidine
Pyrimidone
Hydropyrimidine
Pyrimidine
Imidolactam
Heteroaromatic compound
Tetrahydrofuran
Secondary alcohol
Azacycle
Oxacycle
Organoheterocyclic compound
Alcohol
Hydrocarbon derivative
Organic oxide
Organopnictogen compound
Primary amine
Primary alcohol
Organooxygen compound
Organonitrogen compound
Organic oxygen compound
Organic nitrogen compound
Amine
Aromatic heteromonocyclic compound

Molecular Framework

Aromatic heteromonocyclic compounds

External Descriptors

pyrimidine 2'-deoxyribonucleoside (CHEBI:15698 )
Deoxyribonucleosides (C00881 )

Ontology

Disposition

Route of exposure:

Enteral:

Ingestion

Source:

Biological:

Plant:

Animal

Biological location:

Tissue and substructures:

All tissues

Biofluid and excreta:

Cell and elements:

Extracellular

Subcellular:

Process

Naturally occurring process:

Biological process:

Biochemical pathway:

Role

Industrial application:

Pharmaceutical industry:

Pharmaceutical

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	207 - 210 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	870 mg/mL	Not Available
LogP	-1.77	HANSCH,C ET AL. (1995)

Predicted Molecular Properties

Property	Value	Source
Water Solubility	15.9 g/L	ALOGPS
logP	-1.9	ALOGPS
logP	-1.9	ChemAxon
logS	-1.2	ALOGPS
pKa (Strongest Acidic)	13.89	ChemAxon
pKa (Strongest Basic)	0.31	ChemAxon
Physiological Charge	0	ChemAxon
Hydrogen Acceptor Count	6	ChemAxon
Hydrogen Donor Count	3	ChemAxon
Polar Surface Area	108.38 Å²	ChemAxon
Rotatable Bond Count	2	ChemAxon
Refractivity	53.03 m³·mol⁻¹	ChemAxon
Polarizability	21.65 Å³	ChemAxon
Number of Rings	2	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	No	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Spectral Properties

Collision Cross Sections

Name	Adduct	Type	Data Source	Value	Reference
DeepCCS	[M-H]-	Experimental	MetCCS_train_neg	146.842	30932474
AllCCS	[M-H]-	Experimental	Not Available	148.6	http://allccs.zhulab.cn/database/detail?ID=AllCCS00000095
DarkChem	[M+H]+	Predicted	Not Available	149.431	31661259
DarkChem	[M-H]-	Predicted	Not Available	148.182	31661259
AllCCS	[M+H]+	Predicted	Not Available	151.032	32859911
AllCCS	[M-H]-	Predicted	Not Available	150.18	32859911

Retention Indices

Underivatized

Not Available

Derivatized

Derivative	Value	Reference
Deoxycytidine,1TMS,#1	2307.797	https://arxiv.org/abs/1905.12712
Deoxycytidine,1TMS,#2	2304.5786	https://arxiv.org/abs/1905.12712
Deoxycytidine,1TMS,#3	2373.7026	https://arxiv.org/abs/1905.12712
Deoxycytidine,2TMS,#1	2266.8008	https://arxiv.org/abs/1905.12712
Deoxycytidine,2TMS,#2	2356.2632	https://arxiv.org/abs/1905.12712
Deoxycytidine,2TMS,#3	2348.1382	https://arxiv.org/abs/1905.12712
Deoxycytidine,2TMS,#4	2328.1748	https://arxiv.org/abs/1905.12712
Deoxycytidine,1TBDMS,#1	2565.2705	https://arxiv.org/abs/1905.12712
Deoxycytidine,1TBDMS,#2	2558.6035	https://arxiv.org/abs/1905.12712
Deoxycytidine,1TBDMS,#3	2636.9604	https://arxiv.org/abs/1905.12712
Deoxycytidine,2TBDMS,#1	2745.3853	https://arxiv.org/abs/1905.12712
Deoxycytidine,2TBDMS,#2	2813.4849	https://arxiv.org/abs/1905.12712
Deoxycytidine,2TBDMS,#3	2804.792	https://arxiv.org/abs/1905.12712
Deoxycytidine,2TBDMS,#4	2776.3352	https://arxiv.org/abs/1905.12712

Spectra

GC-MS

Spectrum Type	Description	Splash Key	Deposition Date	View
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (Non-derivatized) - 70eV, Positive	splash10-0006-9510000000-43f83823bd8a63669514	2016-09-22	View Spectrum
Predicted GC-MS	Predicted GC-MS Spectrum - GC-MS (2 TMS) - 70eV, Positive	splash10-0gb9-4912000000-fef878d78b0000e850bb	2017-10-06	View Spectrum
MS	Mass Spectrum (Electron Ionization)	splash10-0006-9510000000-0d341d698aaedbfca406	2021-09-05	View Spectrum
MS	Mass Spectrum (Electron Ionization)	splash10-0a4i-8900000000-5b42adf83e422cffefb6	2021-09-18	View Spectrum
MS	Mass Spectrum (Electron Ionization)	splash10-0a4i-9800000000-24fa3ff739ff064312ab	2021-09-18	View Spectrum

LC-MS/MS

Spectrum Type	Description	Splash Key	Deposition Date	View
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 10V, Positive (Annotated)	splash10-03di-0900000000-27431bdd2327f6f2b886	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 25V, Positive (Annotated)	splash10-03di-1900000000-0ea85f3f3940843e385b	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - Quattro_QQQ 40V, Positive (Annotated)	splash10-03dl-9500000000-569e473eba0b700f5b6e	2012-07-24	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative	splash10-004i-0090000000-5c8c0fde4f2163fbc335	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative	splash10-0006-9420000000-28279714b575d59761ce	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative	splash10-0006-9200000000-df7c76b755c9fac5267b	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative	splash10-0006-9100000000-acbd1d7557be6d716a19	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative	splash10-00kf-9100000000-056ef35d3aa743e0d5cf	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive	splash10-03di-0910000000-52e9d173bb94576f7d9e	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive	splash10-03di-0900000000-e06e5a9f19c4162aa24f	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive	splash10-03di-0900000000-551d8ee9679ef3fb65fa	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive	splash10-03di-3900000000-4c62633283ba566dbee0	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positive	splash10-03di-0900000000-bac3656523b118a2c1bc	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-IT (LC/MSD Trap XCT, Agilent Technologies) , Positive	splash10-03dj-6900000000-dfa8435d3dd8b8981621	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Positive	splash10-01t9-0690000000-72302b09c51553dde169	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) 30V, Positive	splash10-03fr-0930000000-f5c80400a73719f6211f	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative	splash10-0006-9130000000-c7f95a478d22e3cc83f4	2012-08-31	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-004i-0090000000-af75883dba546c82e7bc	2017-09-14	View Spectrum
LC-MS/MS	LC-MS/MS Spectrum - LC-ESI-QQ , negative	splash10-0006-9420000000-562a675c6278a4ae2bc4	2017-09-14	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Positive	splash10-03di-0900000000-e9d4ffd1148d792f5132	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Positive	splash10-03di-4900000000-b2a5f419f882d45f6ae7	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Positive	splash10-03di-8900000000-0bbcfd7be44c4f38c4fc	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 10V, Negative	splash10-004i-1890000000-395ff33971fbc8368eca	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 20V, Negative	splash10-0016-4910000000-2dc8aa3aad2b1c83316f	2016-09-12	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - 40V, Negative	splash10-0006-9200000000-cc82bf3d145faf0a6ca3	2016-09-12	View Spectrum

NMR

Spectrum Type	Description	Deposition Date	View
1D NMR	¹H NMR Spectrum (1D, 600 MHz, H₂O, experimental)	2012-12-04	View Spectrum
1D NMR	¹³C NMR Spectrum (1D, 400 MHz, H₂O, experimental)	2012-12-04	View Spectrum
2D NMR	[¹H, ¹³C] NMR Spectrum (2D, 600 MHz, H₂O, predicted)	2012-12-04	View Spectrum

Biological Properties

Cellular Locations

Extracellular
Mitochondria
Nucleus
Lysosome

Biospecimen Locations

Blood
Feces
Urine

Tissue Locations

All Tissues

Pathways

Name	SMPDB/Pathwhiz	KEGG
Pyrimidine Metabolism
Beta Ureidopropionase Deficiency		Not Available
UMP Synthase Deficiency (Orotic Aciduria)		Not Available
Dihydropyrimidinase Deficiency		Not Available
MNGIE (Mitochondrial Neurogastrointestinal Encephalopathy)		Not Available

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	0.2 (0.0-0.5) uM	Adult (>18 years old)	Both	Normal	3243806	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	29808030	details
Feces	Detected but not Quantified	Not Quantified	Children (6 - 18 years old)	Not Specified	Normal	27609529	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	25037050	details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Normal	27543620	details
Urine	Detected and Quantified	0.65 +/- 0.27 umol/mmol creatinine	Adult (>18 years old)	Both	Normal	15116424	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Feces	Detected but not Quantified	Not Quantified	Adult (>18 years old)	Both	Colorectal cancer	25037050	details
Feces	Detected but not Quantified	Not Quantified	Children (6 - 18 years old)	Not Specified	Crohns disease	27609529	details
Feces	Detected but not Quantified	Not Quantified	Children (6 - 18 years old)	Not Specified	Ulcerative colitis	27609529	details
Feces	Detected but not Quantified	Not Quantified	Children (6 - 18 years old)	Not Specified	Unclassified IBD	27609529	details

Associated Disorders and Diseases

Disease References

Crohn's disease
Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Ulcerative colitis
Kolho KL, Pessia A, Jaakkola T, de Vos WM, Velagapudi V: Faecal and Serum Metabolomics in Paediatric Inflammatory Bowel Disease. J Crohns Colitis. 2017 Mar 1;11(3):321-334. doi: 10.1093/ecco-jcc/jjw158. [PubMed:27609529 ]
Colorectal cancer
Goedert JJ, Sampson JN, Moore SC, Xiao Q, Xiong X, Hayes RB, Ahn J, Shi J, Sinha R: Fecal metabolomics: assay performance and association with colorectal cancer. Carcinogenesis. 2014 Sep;35(9):2089-96. doi: 10.1093/carcin/bgu131. Epub 2014 Jul 18. [PubMed:25037050 ]

Associated OMIM IDs

266600 (Crohn's disease)
114500 (Colorectal cancer)

External Links

DrugBank ID

DB02594

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB021871

KNApSAcK ID

Not Available

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

PubChem Compound

PDB ID

Not Available

ChEBI ID

15698

Food Biomarker Ontology

Not Available

VMH ID

DCYT

MarkerDB ID

Not Available

References

Synthesis Reference

Fox, Jack F.; Yung, Naishun; Wempen, Iris; Hoffer, Max. Pyrimidine nucleosides. XII. Direct synthesis of 2'-deoxycytidine and its a-anomer. Journal of the American Chemical Society (1961), 83 4066-50.

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

van den Bosch J, Lubbert M, Verhoef G, Wijermans PW: The effects of 5-aza-2'-deoxycytidine (Decitabine) on the platelet count in patients with intermediate and high-risk myelodysplastic syndromes. Leuk Res. 2004 Aug;28(8):785-90. [PubMed:15203276 ]
Lee SH, Jung BH, Kim SY, Chung BC: A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18(9):973-7. [PubMed:15116424 ]
Wepierre J, Marty JP, Chanal JL, Sincholle D: Percutaneous absorption of 5-iodo-2' deoxycytidine in the hairless rat and in man. Eur J Drug Metab Pharmacokinet. 1984 Jan-Mar;9(1):79-83. [PubMed:6714272 ]
Coral S, Sigalotti L, Altomonte M, Engelsberg A, Colizzi F, Cattarossi I, Maraskovsky E, Jager E, Seliger B, Maio M: 5-aza-2'-deoxycytidine-induced expression of functional cancer testis antigens in human renal cell carcinoma: immunotherapeutic implications. Clin Cancer Res. 2002 Aug;8(8):2690-5. [PubMed:12171902 ]
Olivares J, Verdys M: Isocratic high-performance liquid chromatographic method for studying the metabolism of blood plasma pyrimidine nucleosides and bases: concentration and radioactivity measurements. J Chromatogr. 1988 Dec 29;434(1):111-21. [PubMed:3243806 ]
Lopez-Gomez C, Levy RJ, Sanchez-Quintero MJ, Juanola-Falgarona M, Barca E, Garcia-Diaz B, Tadesse S, Garone C, Hirano M: Deoxycytidine and Deoxythymidine Treatment for Thymidine Kinase 2 Deficiency. Ann Neurol. 2017 May;81(5):641-652. doi: 10.1002/ana.24922. Epub 2017 May 4. [PubMed:28318037 ]
(). Maley, F. et al., J. Biol. Chem., 1958, 233, 1538-1543, (5-diphosphate). .
(). Charubala, R. et al., Synthesis, 1984, 965-968, (5'-(4,4'-dimethoxytrityl) 4N-benzoyl). .
(). Schaller, H. et al., J.A.C.S., 1963, 85, 3821-3827, (5'-(4,4'-dimethoxytrityl) 4N-benzoyl). .
(). Benz, E. et al., J.O.C., 1965, 30, 3067-3071, (4N-benzoyl, 5'-tosyl, 3',4N-dibenzoyl, 4N,5'-dibenzoyl, 5'-tosyl 4N-benzoyl, 5'-trityl 3',4N-dibenzoyl). .
(). Hruska, F.E. et al., Can. J. Chem., 1974, 52, 497-508, (pmr). .
(). Jones, A.J. et al., Proc. Natl. Acad. Sci. U.S.A., 1970, 65, 27-30, CA, 72, 96682j, (cmr). .
(). Miles, H.T., J.A.C.S., 1963, 85, 1007-1008, (ir, pmr). .
(). Young, D.W. et al., Acta Cryst. B, 1975, 31, 961-965, (cryst struct). .
(). Michelson, A.M. et al., J.C.S., 1954, 34-40, (phosphates, 3',4N-di-Ac, 5'-trityl, 5'-trityl 3',4N-di-Ac). .
(). Lewis, R.J., Sax's Dangerous Properties of Industrial Materials, 8th edn., Van Nostrand Reinhold, 1992, DAQ850. .
(). Aldrich Library of 13C and 1H FT NMR Spectra, 1992, 3, 396A, 396C, (nmr). .
(). Stawinski, J. et al., Chem. Comm., 1976, 243-244, (3',4N,5'-tribenzoyl). .
(). Ulbricht TL. Nucleosides. 3. Synthesis of 1-methyl-2'-deoxycytidine, and comments on the N.m.r. spectra of cytosine nucleosides. J Chem Soc Perkin 1. 1965 Sep:6134-5.. .
(). Wang Z, Prudhomme DR, Buck JR, Park M, Rizzo CJ. Stereocontrolled syntheses of deoxyribonucleosides via photoinduced electron-transfer deoxygenation of benzoyl-protected ribo- and arabinonucleosides. J Org Chem. 2000 Sep 22;65(19):5969-85. . .
(). Saneyoshi M, Tohyama J, Nakayama C, Takiya S, Iwabuchi M. Inhibitory effects of 3'deoxycytidine 5'-triphosphate and 3'-deoxyuridine 5'-triphosphate on DNA-dependent RNA polymerases I and II purified from Dictyostelium discoideum cells. Nucleic Acids Res. 1981 Jul 10;9(13):3129-38.. .
(). FOX JJ, WEMPEN I. Pyrimidine nucleosides. Adv Carbohydr Chem. 1959;14:283-380.. .
(). Raffaele Saladino, Enrico Mincione, Claudia Crestini, Maurizio Mezzetti. Transformations of thiopyrimidine and thiopurine nucleosides following oxidation with dimethyldioxirane. Tetrahedron, 1996, 52, 6759-6780. .
(). Aldrich Library of FT-IR Spectra, 1st edn., 1985, 2, 832B, 838D, 839C, (ir). .
(). Yang, J.T. et al., CA, 1966, 65, 12454, (ord). .

Only showing the first 10 proteins. There are 12 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details

1. 5'-nucleotidase

General function:: Involved in hydrolase activity
Specific function:: Hydrolyzes extracellular nucleotides into membrane permeable nucleosides.
Gene Name:: NT5E
Uniprot ID:: P21589
Molecular weight:: 57948.125

Reactions

dCMP + Water → Deoxycytidine + Phosphate	details

Enzyme Details

2. Cytosolic 5'-nucleotidase 1B

General function:: Involved in nucleotide binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides. Helps to regulate adenosine levels (By similarity).
Gene Name:: NT5C1B
Uniprot ID:: Q96P26
Molecular weight:: 68803.055

Reactions

dCMP + Water → Deoxycytidine + Phosphate	details

Enzyme Details

3. Cytosolic 5'-nucleotidase 1A

General function:: Involved in nucleotide binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides and has a broad substrate specificity. Helps to regulate adenosine levels in heart during ischemia and hypoxia.
Gene Name:: NT5C1A
Uniprot ID:: Q9BXI3
Molecular weight:: 41020.145

Reactions

dCMP + Water → Deoxycytidine + Phosphate	details

Enzyme Details

4. 5'(3')-deoxyribonucleotidase, cytosolic type

General function:: Involved in metal ion binding
Specific function:: Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP.
Gene Name:: NT5C
Uniprot ID:: Q8TCD5
Molecular weight:: Not Available

Reactions

dCMP + Water → Deoxycytidine + Phosphate	details

Enzyme Details

5. Deoxycytidine kinase

General function:: Involved in ATP binding
Specific function:: Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Gene Name:: DCK
Uniprot ID:: P27707
Molecular weight:: 30518.315

Reactions

NTP + Deoxycytidine → NDP + dCMP	details
Adenosine triphosphate + Deoxycytidine → ADP + dCMP	details

References

Giovannetti E, Mey V, Loni L, Nannizzi S, Barsanti G, Savarino G, Ricciardi S, Del Tacca M, Danesi R: Cytotoxic activity of gemcitabine and correlation with expression profile of drug-related genes in human lymphoid cells. Pharmacol Res. 2007 Apr;55(4):343-9. Epub 2007 Jan 16. [PubMed:17296311 ]

Enzyme Details

6. 5'(3')-deoxyribonucleotidase, mitochondrial

General function:: Involved in phosphatase activity
Specific function:: Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP.
Gene Name:: NT5M
Uniprot ID:: Q9NPB1
Molecular weight:: Not Available

Reactions

dCMP + Water → Deoxycytidine + Phosphate	details

Enzyme Details

7. AID

General function:: Involved in zinc ion binding
Specific function:: Not Available
Gene Name:: AID
Uniprot ID:: Q546Y9
Molecular weight:: 23953.3

Enzyme Details

8. Cytosolic 5'-nucleotidase 3

General function:: Involved in magnesium ion binding
Specific function:: Can act both as nucleotidase and as phosphotransferase.
Gene Name:: NT5C3
Uniprot ID:: Q9H0P0
Molecular weight:: 33914.91

Reactions

dCMP + Water → Deoxycytidine + Phosphate	details

Enzyme Details

9. Cytosolic purine 5'-nucleotidase

General function:: Involved in 5'-nucleotidase activity
Specific function:: May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides.
Gene Name:: NT5C2
Uniprot ID:: P49902
Molecular weight:: 64969.2

Reactions

dCMP + Water → Deoxycytidine + Phosphate	details

Enzyme Details

10. Cytidine deaminase

General function:: Involved in zinc ion binding
Specific function:: This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
Gene Name:: CDA
Uniprot ID:: P32320
Molecular weight:: 16184.545

Reactions

Deoxycytidine + Water → Deoxyuridine + Ammonia	details

Only showing the first 10 proteins. There are 12 proteins in total.

Show all enzymes and transporters

Showing metabocard for Deoxycytidine (HMDB0000014)

MOL for HMDB0000014 (Deoxycytidine)

3D MOL for HMDB0000014 (Deoxycytidine)

3D SDF for HMDB0000014 (Deoxycytidine)

3D-SDF for HMDB0000014 (Deoxycytidine)

PDB for HMDB0000014 (Deoxycytidine)

3D PDB for HMDB0000014 (Deoxycytidine)

SMILES for HMDB0000014 (Deoxycytidine)

INCHI for HMDB0000014 (Deoxycytidine)

Structure for HMDB0000014 (Deoxycytidine)

3D Structure for HMDB0000014 (Deoxycytidine)

Collision Cross Sections

Retention Indices

Underivatized

Derivatized

GC-MS

LC-MS/MS

NMR

Enzymes

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References

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