Showing metabocard for Glycolic acid (HMDB0000115)

General function:

Involved in glucose-6-phosphate dehydrogenase activity

Specific function:

Produces pentose sugars for nucleic acid synthesis and main producer of NADPH reducing power.

Gene Name:

G6PD

Uniprot ID:

P11413

Molecular weight:

62467.88

References

1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]

General function:

Involved in sulfotransferase activity

Specific function:

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol, and isoform 2 avidly sulfonates pregnenolone but not cholesterol.

Gene Name:

SULT2B1

Uniprot ID:

O00204

Molecular weight:

39598.595

Reactions

General function:

Involved in oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

Specific function:

Enzyme with hydroxy-pyruvate reductase, glyoxylate reductase and D-glycerate dehydrogenase enzymatic activities. Reduces hydroxypyruvate to D-glycerate, glyoxylate to glycolate oxidizes D-glycerate to hydroxypyruvate.

Gene Name:

GRHPR

Uniprot ID:

Q9UBQ7

Molecular weight:

35667.875

Reactions

General function:

Involved in monooxygenase activity

Specific function:

Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate, myristate and palmitate. Has little activity toward prostaglandins A1 and E1. Oxidizes arachidonic acid to 20-hydroxyeicosatetraenoic acid (20-HETE).

Gene Name:

CYP4A11

Uniprot ID:

Q02928

Molecular weight:

59347.31

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isoform glucuronidates bilirubin IX-alpha to form both the IX-alpha-C8 and IX-alpha-C12 monoconjugates and diconjugate. Is also able to catalyze the glucuronidation of 17beta-estradiol, 17alpha-ethinylestradiol, 1-hydroxypyrene, 4-methylumbelliferone, 1-naphthol, paranitrophenol, scopoletin, and umbelliferone.

Gene Name:

UGT1A1

Uniprot ID:

P22309

Molecular weight:

59590.91

Reactions

General function:

Involved in FMN binding

Specific function:

Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.

Gene Name:

HAO1

Uniprot ID:

Q9UJM8

Molecular weight:

40923.945

Reactions

General function:

Involved in FMN binding

Specific function:

Catalyzes the oxidation of L-alpha-hydroxy acids as well as, more slowly, that of L-alpha-amino acids.

Gene Name:

HAO2

Uniprot ID:

Q9NYQ3

Molecular weight:

38838.35

Reactions

General function:

Involved in catalytic activity

Specific function:

Not Available

Gene Name:

PGP

Uniprot ID:

A6NDG6

Molecular weight:

34005.69

Reactions

General function:

Involved in monooxygenase activity

Specific function:

Catalyzes the omega- and (omega-1)-hydroxylation of various fatty acids such as laurate and palmitate. Shows no activity towards arachidonic acid and prostaglandin A1. Lacks functional activity in the kidney and does not contribute to renal 20-hydroxyeicosatetraenoic acid (20-HETE) biosynthesis.

Gene Name:

CYP4A22

Uniprot ID:

Q5TCH4

Molecular weight:

59245.28

Reactions