Showing metabocard for Glycerol (HMDB0000131)

General function:

Involved in phospholipase A2 activity

Specific function:

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Gene Name:

PLA2G2E

Uniprot ID:

Q9NZK7

Molecular weight:

15988.525

References

1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Gene Name:

AKR1B1

Uniprot ID:

P15121

Molecular weight:

35853.125

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Not Available

Gene Name:

CPT1B

Uniprot ID:

Q92523

Molecular weight:

83890.705

General function:

Involved in acyltransferase activity

Specific function:

Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism.

Gene Name:

CPT1A

Uniprot ID:

P50416

Molecular weight:

86238.415

General function:

Involved in catalytic activity

Specific function:

The primary function of this lipase is the hydrolysis of triglycerides of circulating chylomicrons and very low density lipoproteins (VLDL). Binding to heparin sulfate proteogylcans at the cell surface is vital to the function. The apolipoprotein, APOC2, acts as a coactivator of LPL activity in the presence of lipids on the luminal surface of vascular endothelium (By similarity).

Gene Name:

LPL

Uniprot ID:

P06858

Molecular weight:

53162.07

Reactions

General function:

Involved in acyltransferase activity

Specific function:

Not Available

Gene Name:

CPT2

Uniprot ID:

P23786

Molecular weight:

73776.335

General function:

Lipid transport and metabolism

Specific function:

Converts monoacylglycerides to free fatty acids and glycerol. Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (By similarity). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth.

Gene Name:

MGLL

Uniprot ID:

Q99685

Molecular weight:

Not Available

Reactions

General function:

Involved in calcium ion binding

Specific function:

Inhibitor of phospholipase A2, also possesses anti- coagulant properties. Also cleaves the cyclic bond of inositol 1,2-cyclic phosphate to form inositol 1-phosphate

Gene Name:

ANXA3

Uniprot ID:

P12429

Molecular weight:

36374.8

General function:

Involved in ATP binding

Specific function:

Bifunctional enzyme with both ATP sulfurylase and APS kinase activity, which mediates two steps in the sulfate activation pathway. The first step is the transfer of a sulfate group to ATP to yield adenosine 5'-phosphosulfate (APS), and the second step is the transfer of a phosphate group from ATP to APS yielding 3'-phosphoadenylylsulfate (PAPS: activated sulfate donor used by sulfotransferase). In mammals, PAPS is the sole source of sulfate; APS appears to be only an intermediate in the sulfate-activation pathway. Also involved in the biosynthesis of sulfated L-selectin ligands in endothelial cells.

Gene Name:

PAPSS1

Uniprot ID:

O43252

Molecular weight:

70832.725

References

1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

LPH splits lactose in the small intestine.

Gene Name:

LCT

Uniprot ID:

P09848

Molecular weight:

218584.77