Showing metabocard for Sphingosine 1-phosphate (HMDB0000277)

General function:

Involved in catalytic activity

Specific function:

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is PA > C-1-P > LPA > S-1-P.

Gene Name:

PPAP2C

Uniprot ID:

O43688

Molecular weight:

32573.435

Reactions

General function:

Involved in catalytic activity

Specific function:

Broad-specificity phosphohydrolase that dephosphorylates exogenous bioactive glycerolipids and sphingolipids. Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). Pivotal regulator of lysophosphatidic acid (LPA) signaling in the cardiovascular system. Major enzyme responsible of dephosphorylating LPA in platelets, which terminates signaling actions of LPA. May control circulating, and possibly also regulate localized, LPA levels resulting from platelet activation. It has little activity towards ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA > PA > S-1-P > C-1-P. It's down-regulation may contribute to the development of colon adenocarcinoma.

Gene Name:

PPAP2A

Uniprot ID:

O14494

Molecular weight:

32155.715

Reactions

General function:

Involved in catalytic activity

Specific function:

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P). The relative catalytic efficiency is LPA = PA > C-1-P > S-1-P. May be involved in cell adhesion and in cell-cell interactions.

Gene Name:

PPAP2B

Uniprot ID:

O14495

Molecular weight:

35115.61

Reactions

General function:

Involved in transferase activity, transferring hexosyl groups

Specific function:

Catalyzes the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate. Glycolipids probably serve for adherence of some pathogens

Gene Name:

GBGT1

Uniprot ID:

Q8N5D6

Molecular weight:

40126.9

General function:

Involved in N-acetylglucosaminylphosphatidylinositol de

Specific function:

Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol.

Gene Name:

PIGL

Uniprot ID:

Q9Y2B2

Molecular weight:

28530.965

General function:

Involved in phosphatidylinositol N-acetylglucosaminyltransferase activity

Specific function:

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Gene Name:

PIGQ

Uniprot ID:

Q9BRB3

Molecular weight:

65343.25

General function:

Involved in biosynthetic process

Specific function:

Necessary for the synthesis of N-acetylglucosaminyl-phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.

Gene Name:

PIGA

Uniprot ID:

P37287

Molecular weight:

54126.065

General function:

Involved in phosphatidylinositol N-acetylglucosaminyltr

Specific function:

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Gene Name:

PIGH

Uniprot ID:

Q14442

Molecular weight:

21080.415

General function:

Involved in phosphatidylinositol N-acetylglucosaminyltr

Specific function:

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Gene Name:

PIGP

Uniprot ID:

P57054

Molecular weight:

18089.055

General function:

Involved in phosphatidylinositol N-acetylglucosaminyltransferase activity

Specific function:

Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.

Gene Name:

PIGC

Uniprot ID:

Q92535

Molecular weight:

33582.18