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Identification Taxonomy Ontology Physical properties Spectra Biological properties Concentrations Links References enzymes (189)transporters (2) Show 191 proteins XML

enzymes (189)transporters (2) Show 191 proteins

Record Information

Version

5.0

Status

Detected and Quantified

Creation Date

2006-08-16 12:15:16 UTC

Update Date

2022-03-07 02:49:05 UTC

HMDB ID

HMDB0000692

Secondary Accession Numbers

HMDB00692

Metabolite Identification

Common Name

Fe2+

Description

Iron is a chemical element with the symbol Fe and atomic number 26. Iron makes up 5% of the Earth's crust and is second in abundance to aluminium among the metals and fourth in abundance among the elements. Physiologically, it. exists as an ion in the body. Iron (as Fe2+, ferrous ion) is a necessary trace element used by all known living organisms. Iron-containing enzymes, usually containing heme prosthetic groups, participate in catalysis of oxidation reactions in biology, and in transport of a number of soluble gases. Iron is an essential constituent of hemoglobin, cytochrome, and other components of respiratory enzyme systems. Its chief functions are in the transport of oxygen to tissue (hemoglobin) and in cellular oxidation mechanisms. Inorganic iron involved in redox reactions is also found in the iron-sulfur clusters of many enzymes, such as nitrogenase (involved in the synthesis of ammonia from nitrogen and hydrogen) and hydrogenase. A class of non-heme iron proteins is responsible for a wide range of functions such as ribonucleotide reductase (reduces ribose to deoxyribose; DNA biosynthesis) and purple acid phosphatase (hydrolysis of phosphate esters). When the body is fighting a bacterial infection, the body sequesters iron inside of cells (mostly stored in the storage molecule ferritin) so that it cannot be used by bacteria. Depletion of iron stores may result in iron-deficiency anemia. Iron is used to build up the blood in anemia. Humans experience iron toxicity above 20 milligrams of iron for every kilogram of weight, and 60 milligrams per kilogram is a lethal dose. Over-consumption of iron, often the result of children eating large quantities of ferrous sulfate tablets intended for adult consumption, is the most common toxicological cause of death in children under six. The DRI lists the Tolerable Upper Intake Level (UL) for adults as 45 mg/day. For children under fourteen years old the UL is 40 mg/day. Iron is a metal extracted from iron ore, and is almost never found in the free elemental state.

Structure

MOL 3D MOL SDF 3D SDF PDB 3D PDB SMILES InChI

View in JSmol View Stereo Labels

Synonyms

Value	Source
FE (II) ion	ChEBI
Fe(II)	ChEBI
Fe2+	ChEBI
Fe(2+)	ChEBI
Ferrous ion	ChEBI
Iron ion(2+)	ChEBI
Iron(2+)	Kegg
Armco iron	HMDB
Carbonyl iron	HMDB
FE	HMDB
Ferrovac e	HMDB
Hematite	HMDB
Infed	HMDB
Limonite	HMDB
LOHA	HMDB
Magnetite	HMDB
Malleable iron	HMDB
Metopirone	HMDB
Metyrapone	HMDB
PZH2m	HMDB
PZHO	HMDB
Remko	HMDB
Suy-b 2	HMDB
Taconite	HMDB
Venofer	HMDB
Wrought iron	HMDB
Iron hydroxide (fe(OH)3)	MeSH, HMDB
Iron oxyhydroxide	MeSH, HMDB
Ferric hydroxide	MeSH, HMDB
Iron hydroxide (III)	MeSH, HMDB

Chemical Formula

Average Molecular Weight

55.845

Monoisotopic Molecular Weight

55.934942133

IUPAC Name

lambda2-iron(2+) ion

Traditional Name

lambda2-iron(2+) ion

CAS Registry Number

15438-31-0

SMILES

[Fe++]

InChI Identifier

InChI=1S/Fe/q+2

InChI Key

CWYNVVGOOAEACU-UHFFFAOYSA-N

Chemical Taxonomy

Description

Belongs to the class of inorganic compounds known as homogeneous transition metal compounds. These are inorganic compounds containing only metal atoms,with the largest atom being a transition metal atom.

Kingdom

Inorganic compounds

Super Class

Homogeneous metal compounds

Class

Homogeneous transition metal compounds

Sub Class

Not Available

Direct Parent

Homogeneous transition metal compounds

Alternative Parents

Not Available

Substituents

Homogeneous transition metal

Molecular Framework

Not Available

External Descriptors

monoatomic dication (CHEBI:29033 )
divalent metal cation (CHEBI:29033 )
iron cation (CHEBI:29033 )
a cation (FE+2 )

Ontology

Not Available

Physical Properties

State

Solid

Experimental Molecular Properties

Property	Value	Reference
Melting Point	1538 °C	Not Available
Boiling Point	Not Available	Not Available
Water Solubility	Not Available	Not Available
LogP	Not Available	Not Available

Experimental Chromatographic Properties

Not Available

Predicted Molecular Properties

Property	Value	Source
logP	-0.77	ChemAxon
pKa (Strongest Acidic)	4.58	ChemAxon
Physiological Charge	2	ChemAxon
Hydrogen Acceptor Count	0	ChemAxon
Hydrogen Donor Count	0	ChemAxon
Polar Surface Area	0 Å²	ChemAxon
Rotatable Bond Count	0	ChemAxon
Refractivity	0 m³·mol⁻¹	ChemAxon
Polarizability	1.78 Å³	ChemAxon
Number of Rings	0	ChemAxon
Bioavailability	Yes	ChemAxon
Rule of Five	Yes	ChemAxon
Ghose Filter	No	ChemAxon
Veber's Rule	Yes	ChemAxon
MDDR-like Rule	No	ChemAxon

Predicted Chromatographic Properties

Predicted Kovats Retention Indices

Underivatized

Metabolite	SMILES	Kovats RI Value	Column Type	Reference
Fe2+	[Fe++]	701.9	Standard polar	33892256
Fe2+	[Fe++]	271.5	Standard non polar	33892256
Fe2+	[Fe++]	55.1	Semi standard non polar	33892256

Spectra

MS/MS Spectra

Spectrum Type	Description	Splash Key	Deposition Date	Source	View
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Fe2+ 10V, Positive-QTOF	splash10-0a4i-9000000000-af3e7aec4f5bd9668683	2016-08-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Fe2+ 20V, Positive-QTOF	splash10-0a4i-9000000000-af3e7aec4f5bd9668683	2016-08-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Fe2+ 40V, Positive-QTOF	splash10-0a4i-9000000000-af3e7aec4f5bd9668683	2016-08-01	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Fe2+ 10V, Negative-QTOF	splash10-0udi-9000000000-3335fec4c3184739b75e	2016-08-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Fe2+ 20V, Negative-QTOF	splash10-0udi-9000000000-3335fec4c3184739b75e	2016-08-03	Wishart Lab	View Spectrum
Predicted LC-MS/MS	Predicted LC-MS/MS Spectrum - Fe2+ 40V, Negative-QTOF	splash10-0udi-9000000000-3335fec4c3184739b75e	2016-08-03	Wishart Lab	View Spectrum

Biological Properties

Cellular Locations

Extracellular
Mitochondria

Biospecimen Locations

Blood
Cerebrospinal Fluid (CSF)
Saliva
Urine

Tissue Locations

Brain
Liver

Pathways

Name	SMPDB/PathBank	KEGG
Carnitine Synthesis		Not Available
Tyrosine metabolism	Not Available
Aromatic L-Aminoacid Decarboxylase Deficiency		Not Available
Tyrosine hydroxylase deficiency		Not Available
Cysteine Metabolism

Normal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	9766 +/- 1246 uM	Adult (>18 years old)	Both	Normal	16244395	details
Blood	Detected and Quantified	8050.0 (7500.0-8600.0) uM	Adult (>18 years old)	Female	Normal	Geigy Scientific ...	details
Blood	Detected and Quantified	8950.0 (7900.0-10000.0) uM	Adult (>18 years old)	Male	Normal	Geigy Scientific ...	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	3.6 +/- 3.6 uM	Elderly (>65 years old)	Both	Normal	9720975	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	9.293 +/- 1.140 uM	Adult (>18 years old)	Not Specified	Normal	22546835	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.8 (0.3-0.5) uM	Adult (>18 years old)	Both	Normal	Geigy Scientific ...	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.783 +/- 0.551 uM	Adult (>18 years old)	Female	Normal	20087382	details
Saliva	Detected and Quantified	5.918 +/- 2.530 uM	Adult (>18 years old)	Both	Normal	Zerihun T. Dame, ...	details
Saliva	Detected and Quantified	0.448-2.865 uM	Children (1-13 years old)	Both	Normal	Gian Paolo Sighin...	details
Saliva	Detected and Quantified	84.699 +/- 47.274 uM	Adult (>18 years old)	Male	Normal	10378074	details
Saliva	Detected and Quantified	80.759 +/- 38.141 uM	Adult (>18 years old)	Male	Normal	10378074	details
Saliva	Detected and Quantified	13286.776 +/- 7288.0294 uM	Children (1-13 years old)	Both	Normal	22973495	details
Saliva	Detected and Quantified	18.605 +/- 1.726 uM	Children (1-13 years old)	Not Specified	Normal	1569637	details
Saliva	Detected and Quantified	5.551 +/- 1.253 uM	Adult (>18 years old)	Not Specified	Normal	Natheer H. Al-Raw...	details
Urine	Detected and Quantified	0.0890 (0.0025-0.4579) umol/mmol creatinine	Adult (>18 years old)	Both	Normal	24023812	details
Urine	Detected and Quantified	0.11 (0.0-0.14) umol/mmol creatinine	Adult (>18 years old)	Both	Normal	Geigy Scientific ... West Cadwell, N.J... Basel, Switzerlan...	details
Urine	Detected and Quantified	0.029 (0.014-0.053) umol/mmol creatinine	Adult (>18 years old)	Male	Normal	Geigy Scientific ... West Cadwell, N.J... Basel, Switzerlan...	details

Abnormal Concentrations

Biospecimen	Status	Value	Age	Sex	Condition	Reference	Details
Blood	Detected and Quantified	8631 +/- 1497 uM	Adult (>18 years old)	Both	Multiple sclerosis	16244395	details
Blood	Detected and Quantified	20.1 +/- 7.7 uM	Adult (>18 years old)	Both	Parkinson's disease	16244392	details
Blood	Detected and Quantified	16.3 +/- 7.7 uM	Elderly (>65 years old)	Both	Alzheimer's disease	16244393	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	0.488 +/- 0.374 uM	Adult (>18 years old)	Not Specified	fibromyalgia	20087382	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	1.8 +/- 1.8 uM	Elderly (>65 years old)	Both	Alzheimer's disease	9720975	details
Cerebrospinal Fluid (CSF)	Detected and Quantified	2.5 +/- 1.8 uM	Elderly (>65 years old)	Not Specified	Alzheimer's disease	9720975	details
Saliva	Detected and Quantified	45303.966 +/- 16295.103 uM	Children (1-13 years old)	Both	Thalassemia Major	22973495	details
Saliva	Detected and Quantified	26877.966 +/- 10940.997 uM	Children (1-13 years old)	Both	Thalassemia intermedia	22973495	details
Saliva	Detected and Quantified	18103.680 +/- 7370.400 uM	Adolescent (13-18 years old)	Both	Thalassemia Trait	22973495	details
Saliva	Detected and Quantified	4405.0497 +/- 1790.671 uM	Children (1-13 years old)	Both	Iron Deficiency	22973495	details
Saliva	Detected and Quantified	24.008 +/- 6.984 uM	Children (1-13 years old)	Not Specified	Iron Deficiency	1569637	details
Saliva	Detected and Quantified	33.172 +/- 8.529 uM	Children (1-13 years old)	Not Specified	Thalassemia Major	1569637	details
Saliva	Detected and Quantified	40.971 +/- 9.292 uM	Children (1-13 years old)	Not Specified	Aplastic anemia	1569637	details
Saliva	Detected and Quantified	2.507 +/- 0.537 uM	Adult (>18 years old)	Not Specified	Oral squamous cell carcinoma	Natheer H. Al-Raw...	details
Saliva	Detected and Quantified	2.686 +/- 1.253 uM	Adult (>18 years old)	Not Specified	Oral squamous cell carcinoma	Natheer H. Al-Raw...	details
Saliva	Detected and Quantified	3.402 +/- 0.537 uM	Adult (>18 years old)	Not Specified	Oral squamous cell carcinoma	Natheer H. Al-Raw...	details

Associated Disorders and Diseases

Disease References

Multiple sclerosis
Forte G, Visconti A, Santucci S, Ghazaryan A, Figa-Talamanca L, Cannoni S, Bocca B, Pino A, Violante N, Alimonti A, Salvetti M, Ristori G: Quantification of chemical elements in blood of patients affected by multiple sclerosis. Ann Ist Super Sanita. 2005;41(2):213-6. [PubMed:16244395 ]
Parkinson's disease
Forte G, Alimonti A, Pino A, Stanzione P, Brescianini S, Brusa L, Sancesario G, Violante N, Bocca B: Metals and oxidative stress in patients with Parkinson's disease. Ann Ist Super Sanita. 2005;41(2):189-95. [PubMed:16244392 ]
Alzheimer's disease
Molina JA, Jimenez-Jimenez FJ, Aguilar MV, Meseguer I, Mateos-Vega CJ, Gonzalez-Munoz MJ, de Bustos F, Porta J, Orti-Pareja M, Zurdo M, Barrios E, Martinez-Para MC: Cerebrospinal fluid levels of transition metals in patients with Alzheimer's disease. J Neural Transm (Vienna). 1998;105(4-5):479-88. [PubMed:9720975 ] Bocca B, Forte G, Petrucci F, Pino A, Marchione F, Bomboi G, Senofonte O, Giubilei F, Alimonti A: Monitoring of chemical elements and oxidative damage in patients affected by Alzheimer's disease. Ann Ist Super Sanita. 2005;41(2):197-203. [PubMed:16244393 ]
Fibromyalgia
Ortancil O, Sanli A, Eryuksel R, Basaran A, Ankarali H: Association between serum ferritin level and fibromyalgia syndrome. Eur J Clin Nutr. 2010 Mar;64(3):308-12. doi: 10.1038/ejcn.2009.149. Epub 2010 Jan 20. [PubMed:20087382 ]
Iron deficiency
Canatan D, Akdeniz SK: Iron and ferritin levels in saliva of patients with thalassemia and iron deficiency anemia. Mediterr J Hematol Infect Dis. 2012;4(1):e2012051. doi: 10.4084/MJHID.2012.051. Epub 2012 Aug 9. [PubMed:22973495 ] Mishra OP, Agarwal KN, Agarwal RM: Salivary iron status in children with iron deficiency and iron overload. J Trop Pediatr. 1992 Apr;38(2):64-7. [PubMed:1569637 ]

Associated OMIM IDs

126200 (Multiple sclerosis)
168600 (Parkinson's disease)
104300 (Alzheimer's disease)

External Links

DrugBank ID

Not Available

Phenol Explorer Compound ID

Not Available

FooDB ID

FDB030855

KNApSAcK ID

Not Available

Chemspider ID

KEGG Compound ID

BioCyc ID

BiGG ID

Wikipedia Link

METLIN ID

Not Available

PubChem Compound

27284

PDB ID

FE2

ChEBI ID

29033

Food Biomarker Ontology

Not Available

VMH ID

Not Available

MarkerDB ID

MDB00000221

Good Scents ID

Not Available

References

Synthesis Reference

Not Available

Material Safety Data Sheet (MSDS)

Download (PDF)

General References

Gal S, Fridkin M, Amit T, Zheng H, Youdim MB: M30, a novel multifunctional neuroprotective drug with potent iron chelating and brain selective monoamine oxidase-ab inhibitory activity for Parkinson's disease. J Neural Transm Suppl. 2006;(70):447-56. [PubMed:17017567 ]
Piga A, Galanello R, Forni GL, Cappellini MD, Origa R, Zappu A, Donato G, Bordone E, Lavagetto A, Zanaboni L, Sechaud R, Hewson N, Ford JM, Opitz H, Alberti D: Randomized phase II trial of deferasirox (Exjade, ICL670), a once-daily, orally-administered iron chelator, in comparison to deferoxamine in thalassemia patients with transfusional iron overload. Haematologica. 2006 Jul;91(7):873-80. [PubMed:16818273 ]
Nasolodin VV, Zaitseva IP, Gladkikh IP, Voronin SM: [Correction of iron and immune deficiencies in students from a higher humanitarian educational establishment]. Gig Sanit. 2005 Sep-Oct;(5):64-7. [PubMed:16277000 ]
Custodio PJ, Carvalho ML, Nunes F, Pedroso S, Campos A: Direct analysis of human blood (mothers and newborns) by energy dispersive X-ray fluorescence. J Trace Elem Med Biol. 2005;19(2-3):151-8. Epub 2005 Oct 24. [PubMed:16325530 ]
Agarwal MB: Exjade (ICL 670): A new oral iron chelator. J Assoc Physicians India. 2006 Mar;54:214-7. [PubMed:16800349 ]
Cortese S, Konofal E, Lecendreux M, Mouren MC, Bernardina BD: Restless legs syndrome triggered by heart surgery. Pediatr Neurol. 2006 Sep;35(3):223-6. [PubMed:16939866 ]
Barkova EN, Nazarenko EV, Zhdanova EV: Diurnal variations in qualitative composition of breast milk in women with iron deficiency. Bull Exp Biol Med. 2005 Oct;140(4):394-6. [PubMed:16671562 ]
Christoforidis A, Haritandi A, Tsitouridis I, Tsatra I, Tsantali H, Karyda S, Dimitriadis AS, Athanassiou-Metaxa M: Correlative study of iron accumulation in liver, myocardium, and pituitary assessed with MRI in young thalassemic patients. J Pediatr Hematol Oncol. 2006 May;28(5):311-5. [PubMed:16772883 ]
Kom GD, Schwedhelm E, Nielsen P, Boger RH: Increased urinary excretion of 8-iso-prostaglandin F2alpha in patients with HFE-related hemochromatosis: a case-control study. Free Radic Biol Med. 2006 Apr 1;40(7):1194-200. Epub 2005 Dec 13. [PubMed:16545687 ]
Gerlach M, Double KL, Youdim MB, Riederer P: Potential sources of increased iron in the substantia nigra of parkinsonian patients. J Neural Transm Suppl. 2006;(70):133-42. [PubMed:17017520 ]
Jost PJ, Stengel SM, Huber W, Sarbia M, Peschel C, Duyster J: Very severe iron-deficiency anemia in a patient with celiac disease and bulimia nervosa: a case report. Int J Hematol. 2005 Nov;82(4):310-1. [PubMed:16298820 ]
St Pierre TG, Clark PR, Chua-Anusorn W: Measurement and mapping of liver iron concentrations using magnetic resonance imaging. Ann N Y Acad Sci. 2005;1054:379-85. [PubMed:16339686 ]
Clardy SL, Earley CJ, Allen RP, Beard JL, Connor JR: Ferritin subunits in CSF are decreased in restless legs syndrome. J Lab Clin Med. 2006 Feb;147(2):67-73. [PubMed:16459164 ]
Grosse R, Lund U, Caruso V, Fischer R, Janka GE, Magnano C, Engelhardt R, Durken M, Nielsen P: Non-transferrin-bound iron during blood transfusion cycles in beta-thalassemia major. Ann N Y Acad Sci. 2005;1054:429-32. [PubMed:16339692 ]
Anderson LJ, Westwood MA, Prescott E, Walker JM, Pennell DJ, Wonke B: Development of thalassaemic iron overload cardiomyopathy despite low liver iron levels and meticulous compliance to desferrioxamine. Acta Haematol. 2006;115(1-2):106-8. [PubMed:16424659 ]
Matinaho S, Karhumaki P, Parkkinen J: Bicarbonate inhibits the growth of Staphylococcus epidermidis in platelet concentrates by lowering the level of non-transferrin-bound iron. Transfusion. 2005 Nov;45(11):1768-73. [PubMed:16271102 ]
Blanck HM, Cogswell ME, Gillespie C, Reyes M: Iron supplement use and iron status among US adults: results from the third National Health and Nutrition Examination Survey. Am J Clin Nutr. 2005 Nov;82(5):1024-31. [PubMed:16280434 ]
Yarali N, Fisgin T, Duru F, Kara A, Ecin N, Fitoz S, Erden I: Subcutaneous bolus injection of deferoxamine is an alternative method to subcutaneous continuous infusion. J Pediatr Hematol Oncol. 2006 Jan;28(1):11-6. [PubMed:16394886 ]
Walter PB, Fung EB, Killilea DW, Jiang Q, Hudes M, Madden J, Porter J, Evans P, Vichinsky E, Harmatz P: Oxidative stress and inflammation in iron-overloaded patients with beta-thalassaemia or sickle cell disease. Br J Haematol. 2006 Oct;135(2):254-63. [PubMed:17010049 ]
Kontoghiorghes GJ, Kolnagou A: Molecular factors and mechanisms affecting iron and other metal excretion or absorption in health and disease: the role of natural and synthetic chelators. Curr Med Chem. 2005;12(23):2695-709. [PubMed:16305466 ]

Only showing the first 10 proteins. There are 191 proteins in total.

Show all enzymes and transporters

Enzymes

Enzyme Details

1. 5-aminolevulinate synthase, erythroid-specific, mitochondrial

General function:: Involved in 5-aminolevulinate synthase activity
Specific function:: Not Available
Gene Name:: ALAS2
Uniprot ID:: P22557
Molecular weight:: 64632.86

Enzyme Details

2. 85/88 kDa calcium-independent phospholipase A2

General function:: Involved in metabolic process
Specific function:: Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
Gene Name:: PLA2G6
Uniprot ID:: O60733
Molecular weight:: 84092.635

Enzyme Details

3. Tartrate-resistant acid phosphatase type 5

General function:: Involved in hydrolase activity
Specific function:: Involved in osteopontin/bone sialoprotein dephosphorylation. Its expression seems to increase in certain pathological states such as Gaucher and Hodgkin diseases, the hairy cell, the B-cell, and the T-cell leukemias.
Gene Name:: ACP5
Uniprot ID:: P13686
Molecular weight:: 36598.47

Enzyme Details

4. Ribonucleoside-diphosphate reductase large subunit

General function:: Involved in oxidation reduction
Specific function:: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
Gene Name:: RRM1
Uniprot ID:: P23921
Molecular weight:: 90069.375

Enzyme Details

5. Ribonucleoside-diphosphate reductase subunit M2

General function:: Involved in oxidoreductase activity
Specific function:: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. Inhibits Wnt signaling.
Gene Name:: RRM2
Uniprot ID:: P31350
Molecular weight:: 44877.25

Enzyme Details

6. NADH-ubiquinone oxidoreductase chain 1

General function:: Involved in oxidation reduction
Specific function:: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Gene Name:: MT-ND1
Uniprot ID:: P03886
Molecular weight:: 35660.055

Enzyme Details

7. NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

General function:: Involved in NADH dehydrogenase activity
Specific function:: Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Gene Name:: NDUFB1
Uniprot ID:: O75438
Molecular weight:: 6961.2

Enzyme Details

8. NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

General function:: Involved in oxidoreductase activity, acting on NADH or NADPH
Specific function:: Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).
Gene Name:: NDUFS2
Uniprot ID:: O75306
Molecular weight:: 51851.59

Enzyme Details

9. Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

General function:: Involved in succinate dehydrogenase activity
Specific function:: Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Gene Name:: SDHC
Uniprot ID:: Q99643
Molecular weight:: 16650.185

Enzyme Details

10. Peroxisomal N(1)-acetyl-spermine/spermidine oxidase

General function:: Amino acid transport and metabolism
Specific function:: Flavoenzyme which catalyzes the oxidation of N(1)-acetylspermine to spermidine and is thus involved in the polyamine back-conversion. Can also oxidize N(1)-acetylspermidine to putrescine. Substrate specificity: N(1)-acetylspermine = N(1)-acetylspermidine > N(1),N(12)-diacylspermine >> spermine. Does not oxidize spermidine. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs.
Gene Name:: PAOX
Uniprot ID:: Q6QHF9
Molecular weight:: 55512.64

Transporters

Enzyme Details

1. Cubilin

General function:: Involved in calcium ion binding
Specific function:: Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands required calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface
Gene Name:: CUBN
Uniprot ID:: O60494
Molecular weight:: 398672.8

Enzyme Details

2. Proton-coupled folate transporter

General function:: Involved in transmembrane transport
Specific function:: Has been shown to act both as an intestinal proton- coupled high-affinity folate transporter and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. The iron is then released from heme and may be transported into the bloodstream. Dietary heme iron is an important nutritional source of iron. Shows a higher affinity for folate than heme
Gene Name:: SLC46A1
Uniprot ID:: Q96NT5
Molecular weight:: 49770.0

Only showing the first 10 proteins. There are 191 proteins in total.

Show all enzymes and transporters

Showing metabocard for Fe2+ (HMDB0000692)

MOL for HMDB0000692 (Fe2+)

3D MOL for HMDB0000692 (Fe2+)

3D SDF for HMDB0000692 (Fe2+)

3D-SDF for HMDB0000692 (Fe2+)

PDB for HMDB0000692 (Fe2+)

3D PDB for HMDB0000692 (Fe2+)

SMILES for HMDB0000692 (Fe2+)

INCHI for HMDB0000692 (Fe2+)

Structure for HMDB0000692 (Fe2+)

3D Structure for HMDB0000692 (Fe2+)

Predicted Kovats Retention Indices

Underivatized

MS/MS Spectra

Enzymes

Transporters