Showing metabocard for ADP (HMDB0001341)

General function:

Involved in ATP binding

Specific function:

Catalyzes specific phosphoryl transfer from ATP to UMP and CMP.

Gene Name:

CMPK1

Uniprot ID:

P30085

Molecular weight:

20180.12

Reactions

General function:

Involved in ATP binding

Specific function:

Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.

Gene Name:

DCK

Uniprot ID:

P27707

Molecular weight:

30518.315

Reactions

General function:

Involved in ATP citrate synthase activity

Specific function:

ATP citrate-lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. Has a central role in de novo lipid synthesis. In nervous tissue it may be involved in the biosynthesis of acetylcholine.

Gene Name:

ACLY

Uniprot ID:

P53396

Molecular weight:

120838.27

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Gene Name:

ACACB

Uniprot ID:

O00763

Molecular weight:

276538.575

Reactions

General function:

Involved in catalytic activity

Specific function:

Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. Catalyzes in a tissue specific manner, the initial reactions of glucose (liver, kidney) and lipid (adipose tissue, liver, brain) synthesis from pyruvate.

Gene Name:

PC

Uniprot ID:

P11498

Molecular weight:

129632.565

Reactions

General function:

Involved in acetyl-CoA carboxylase activity

Specific function:

Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.

Gene Name:

ACACA

Uniprot ID:

Q13085

Molecular weight:

269997.01

Reactions

General function:

Involved in thymidylate kinase activity

Specific function:

Catalyzes the conversion of dTMP to dTDP.

Gene Name:

DTYMK

Uniprot ID:

P23919

Molecular weight:

23819.105

Reactions

General function:

Involved in hydrolase activity

Specific function:

In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well.

Gene Name:

ENTPD1

Uniprot ID:

P49961

Molecular weight:

58706.0

Reactions

General function:

Involved in calcium ion binding

Specific function:

Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis.

Gene Name:

CANT1

Uniprot ID:

Q8WVQ1

Molecular weight:

44839.24

General function:

Involved in hydrolase activity

Specific function:

Has a threefold preference for the hydrolysis of ATP over ADP.

Gene Name:

ENTPD3

Uniprot ID:

O75355

Molecular weight:

59104.76

Reactions