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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2023-02-21 17:15:45 UTC
HMDB IDHMDB0001525
Secondary Accession Numbers
  • HMDB01525
Metabolite Identification
Common NameImidazole
DescriptionImidazole is an organic compound with the formula C3N2H4. It is a white or colourless solid that is soluble in water, producing a mildly alkaline solution. In chemistry, it is an aromatic heterocycle, classified as a diazole, and has non-adjacent nitrogen atoms. Imidazole is a heterocyclic aromatic organic compound. It is classified as an alkaloid. The ring system of the molecule is present in important biological building blocks such as histidine and histamine. Imidazole can act as a base and as a weak acid. Imidazole exists in two tautomeric forms with the hydrogen atom moving between the two nitrogens. Many drugs contain an imidazole ring, such as antifungal drugs and nitroimidazole. Imidazole is a 5 membered planar ring which is soluble in water and polar solvents. Imidazole is a base and an excellent nucleophile. It reacts at the NH nitrogen, attacking alkylating and acylating compounds. It is not particularly susceptible to electrophilic attacks at the carbon atoms, and most of these reactions are substitutions that keep the aromaticity intact. One can see from the resonance structure that the carbon-2 is the carbon most likely to have a nucleophile attack it, but in general nucleophilic substitutions are difficult with imidazole. Imidazole is incorporated into many important biological molecules. The most obvious is the amino acid histidine, which has an imidazole side chain. histidine is present in many proteins and enzymes and plays a vital part in the structure and binding functions of hemoglobin.
Structure
Data?1676999745
Synonyms
ValueSource
1,3-Diaza-2,4-cyclopentadieneChEBI
1,3-DiazoleChEBI
GlyoxalineChEBI
HimChEBI
IMDChEBI
ImidazolChEBI
IminazoleChEBI
MiazoleChEBI
N,N'-1,2-ethenediylmethanimidamideChEBI
N,N'-vinyleneformamidineChEBI
Pyrro[b]monazoleChEBI
1H-ImidazoleHMDB
GlyoxalinHMDB
ImutexHMDB
Pyrro(b)monazoleHMDB
{Pyrro[b]monazole}HMDB
Imidazole acetateHMDB
Imidazole monophosphonateHMDB
Imidazole sodiumHMDB
Imidazolium chlorideHMDB
Al-imidazoleHMDB
Imidazole citrateHMDB
Cu-imidazoleHMDB
Imidazole conjugate monoacidHMDB
Imidazole monohydrochlorideHMDB
ImidazoleChEBI
Chemical FormulaC3H4N2
Average Molecular Weight68.0773
Monoisotopic Molecular Weight68.037448138
IUPAC Name1H-imidazole
Traditional Nameimidazole
CAS Registry Number288-32-4
SMILES
N1C=CN=C1
InChI Identifier
InChI=1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
InChI KeyRAXXELZNTBOGNW-UHFFFAOYSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as imidazoles. Imidazoles are compounds containing an imidazole ring, which is an aromatic five-member ring with two nitrogen atoms at positions 1 and 3, and three carbon atoms.
KingdomOrganic compounds
Super ClassOrganoheterocyclic compounds
ClassAzoles
Sub ClassImidazoles
Direct ParentImidazoles
Alternative Parents
Substituents
  • Heteroaromatic compound
  • Imidazole
  • Azacycle
  • Organic nitrogen compound
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Aromatic heteromonocyclic compound
Molecular FrameworkAromatic heteromonocyclic compounds
External Descriptors
Ontology
Physiological effect
Disposition
Process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point90.5 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogP-0.08HANSCH,C ET AL. (1995)
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility538 g/LALOGPS
logP-0.21ALOGPS
logP-0.15ChemAxon
logS0.9ALOGPS
pKa (Strongest Acidic)13.4ChemAxon
pKa (Strongest Basic)6.97ChemAxon
Physiological Charge1ChemAxon
Hydrogen Acceptor Count1ChemAxon
Hydrogen Donor Count1ChemAxon
Polar Surface Area28.68 ŲChemAxon
Rotatable Bond Count0ChemAxon
Refractivity19.01 m³·mol⁻¹ChemAxon
Polarizability6.56 ųChemAxon
Number of Rings1ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleYesChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+107.70631661259
DarkChem[M-H]-103.38631661259
AllCCS[M+H]+115.13332859911
AllCCS[M-H]-115.7732859911
DeepCCS[M+H]+119.25530932474
DeepCCS[M-H]-116.96530932474
DeepCCS[M-2H]-152.87830932474
DeepCCS[M+Na]+127.40630932474
AllCCS[M+H]+115.132859911
AllCCS[M+H-H2O]+109.732859911
AllCCS[M+NH4]+120.232859911
AllCCS[M+Na]+121.632859911
AllCCS[M-H]-115.832859911
AllCCS[M+Na-2H]-120.432859911
AllCCS[M+HCOO]-125.432859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
ImidazoleN1C=CN=C12213.1Standard polar33892256
ImidazoleN1C=CN=C1983.4Standard non polar33892256
ImidazoleN1C=CN=C11038.8Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
Imidazole,1TMS,isomer #1C[Si](C)(C)N1C=CN=C11130.2Semi standard non polar33892256
Imidazole,1TMS,isomer #1C[Si](C)(C)N1C=CN=C11085.2Standard non polar33892256
Imidazole,1TMS,isomer #1C[Si](C)(C)N1C=CN=C11352.3Standard polar33892256
Imidazole,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1C=CN=C11349.4Semi standard non polar33892256
Imidazole,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1C=CN=C11260.1Standard non polar33892256
Imidazole,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)N1C=CN=C11520.7Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental GC-MSGC-MS Spectrum - Imidazole EI-B (Non-derivatized)splash10-014l-9000000000-e6b2b7faf77dcf80d5932017-09-12HMDB team, MONA, MassBankView Spectrum
Experimental GC-MSGC-MS Spectrum - Imidazole EI-B (Non-derivatized)splash10-014l-9000000000-e6b2b7faf77dcf80d5932018-05-18HMDB team, MONA, MassBankView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Imidazole GC-MS (Non-derivatized) - 70eV, Positivesplash10-014i-9000000000-ba9a75409716dbd6ae142017-08-28Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - Imidazole GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole Quattro_QQQ 10V, Positive-QTOF (Annotated)splash10-014l-9000000000-2ca95342014cfc85bb742012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole Quattro_QQQ 25V, Positive-QTOF (Annotated)splash10-014i-9000000000-7d24c7b22fb67b2a5b762012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole Quattro_QQQ 40V, Positive-QTOF (Annotated)splash10-014l-9000000000-f50f9a9c83174e9c149f2012-07-24HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole EI-B (HITACHI M-80) , Positive-QTOFsplash10-014l-9000000000-e6b2b7faf77dcf80d5932012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole LC-ESI-QQ (API3000, Applied Biosystems) 10V, Positive-QTOFsplash10-014i-9000000000-76b001eeacbb900271fa2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole LC-ESI-QQ (API3000, Applied Biosystems) 20V, Positive-QTOFsplash10-014i-9000000000-5398a23c5b95419a1e5b2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole LC-ESI-QQ (API3000, Applied Biosystems) 30V, Positive-QTOFsplash10-014i-9000000000-ad715dac27bd6d79523d2012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole LC-ESI-QQ (API3000, Applied Biosystems) 40V, Positive-QTOFsplash10-014i-9000000000-9dad13fc804c087084a82012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole LC-ESI-QQ (API3000, Applied Biosystems) 50V, Positive-QTOFsplash10-014i-9000000000-36c1868da6ae549e0d512012-08-31HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole LC-ESI-QQ , positive-QTOFsplash10-014i-9000000000-76b001eeacbb900271fa2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole LC-ESI-QQ , positive-QTOFsplash10-014i-9000000000-5398a23c5b95419a1e5b2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole LC-ESI-QQ , positive-QTOFsplash10-014i-9000000000-ad715dac27bd6d79523d2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole LC-ESI-QQ , positive-QTOFsplash10-014i-9000000000-9dad13fc804c087084a82017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole LC-ESI-QQ , positive-QTOFsplash10-014l-9000000000-36c1868da6ae549e0d512017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole LC-ESI-QFT , positive-QTOFsplash10-014i-9000000000-0b1bce58fb1f7bcc70932017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - Imidazole 35V, Positive-QTOFsplash10-014l-9000000000-1e75707c493cc0d668852021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Imidazole 10V, Negative-QTOFsplash10-014i-9000000000-b3d4133417298a44a53b2017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Imidazole 20V, Negative-QTOFsplash10-014i-9000000000-ec4b53ab61f0e52b88c12017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Imidazole 40V, Negative-QTOFsplash10-0006-9000000000-eff641f0ad5995348cb62017-07-26Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Imidazole 10V, Negative-QTOFsplash10-014i-9000000000-e5fe87bd22a87dc81aaf2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Imidazole 20V, Negative-QTOFsplash10-014i-9000000000-e5fe87bd22a87dc81aaf2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Imidazole 40V, Negative-QTOFsplash10-0006-9000000000-984396e105296a5464dd2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Imidazole 10V, Positive-QTOFsplash10-014i-9000000000-985af79883cf80d0af6b2017-07-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Imidazole 20V, Positive-QTOFsplash10-014i-9000000000-d6f5b271615f8e978a662017-07-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - Imidazole 40V, Positive-QTOFsplash10-014l-9000000000-4f888ed0233af45d54e52017-07-25Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Experimental 1D NMR1H NMR Spectrum (1D, 500 MHz, H2O, experimental)2012-12-04Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-29Wishart LabView Spectrum
Experimental 1D NMR1H NMR Spectrum (1D, 500 MHz, Methanol, experimental)2021-10-10Wishart LabView Spectrum
Experimental 2D NMR[1H, 13C]-HSQC NMR Spectrum (2D, 400 MHz, H2O, experimental)2012-12-05Wishart LabView Spectrum

IR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M-H]-)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+H]+)2023-02-03FELIX labView Spectrum
Predicted IR SpectrumIR Ion Spectrum (Predicted IRIS Spectrum, Adduct: [M+Na]+)2023-02-03FELIX labView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm (predicted from logP)
Biospecimen Locations
  • Urine
Tissue Locations
  • Adrenal Cortex
  • Adrenal Gland
  • Epidermis
  • Liver
  • Neuron
  • Placenta
  • Platelet
  • Testis
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
UrineDetected and Quantified9.42 umol/mmol creatinineAdult (>18 years old)Male
Normal
    • Shaykhutdinov RA,...
details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDDB03366
Phenol Explorer Compound IDNot Available
FooDB IDFDB012307
KNApSAcK IDNot Available
Chemspider ID773
KEGG Compound IDC01589
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkImidazole
METLIN ID4190
PubChem Compound795
PDB IDNot Available
ChEBI ID16069
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceLu, Zhongmin; Liu, Xinzheng. Review of process for synthesis of imidazole. Huagong Shikan (1999), 13(2), 26-27.
Material Safety Data Sheet (MSDS)Download (PDF)
General References
  1. Bruynseels J, De Coster R, Van Rooy P, Wouters W, Coene MC, Snoeck E, Raeymaekers A, Freyne E, Sanz G, Vanden Bussche G, et al.: R 75251, a new inhibitor of steroid biosynthesis. Prostate. 1990;16(4):345-57. [PubMed:2164659 ]
  2. Sheu JR, Hsiao G, Shen MY, Lin WY, Tzeng CR: The hyperaggregability of platelets from normal pregnancy is mediated through thromboxane A2 and cyclic AMP pathways. Clin Lab Haematol. 2002 Apr;24(2):121-9. [PubMed:11985559 ]
  3. Lamberts SW, Bruining HA, Marzouk H, Zuiderwijk J, Uitterlinden P, Blijd JJ, Hackeng WH, De Jong FH: The new aromatase inhibitor CGS-16949A suppresses aldosterone and cortisol production by human adrenal cells in vitro. J Clin Endocrinol Metab. 1989 Oct;69(4):896-901. [PubMed:2550511 ]
  4. Luft FC, Mann JF: New classes of antihypertensive drugs and new findings with established agents. Curr Opin Nephrol Hypertens. 1992 Oct;1(1):91-9. [PubMed:1365836 ]
  5. Allolio B, Stuttmann R, Winkelmann W: Missing effect of etomidate on testosterone secretion in man. Klin Wochenschr. 1986 Jan 15;64(2):86-8. [PubMed:3005757 ]
  6. Schraag S, Pawlik M, Mohl U, Bohm BO, Georgieff M: The role of ascorbic acid and xylitol in etomidate-induced adrenocortical suppression in humans. Eur J Anaesthesiol. 1996 Jul;13(4):346-51. [PubMed:8842654 ]
  7. Cotovio J, Roguet R, Pion FX, Rougier A, Leclaire J: Effect of imidazole derivatives on cytochrome P-450 enzyme activities in a reconstructed human epidermis. Skin Pharmacol. 1996;9(4):242-9. [PubMed:8896115 ]
  8. Kuhlkamp V, Schmid F, Ress KM, Kramer BK, Mayer F, Liebich HM, Risler T, Seipel L: Quantification of cibenzoline and its imidazole metabolite by high-performance liquid chromatography in human serum. J Chromatogr. 1990 Jun 8;528(1):267-73. [PubMed:2384563 ]
  9. Santella RM, Yang XY, Hsieh LL, Young TL: Immunologic methods for the detection of carcinogen adducts in humans. Prog Clin Biol Res. 1990;340C:247-57. [PubMed:2199982 ]
  10. Howden CW, Kenyon CJ, Beastall GH, Reid JL: Inhibition by omeprazole of adrenocortical response to ACTH: clinical studies and experiments on bovine adrenal cortex in vitro. Clin Sci (Lond). 1986 Jan;70(1):99-102. [PubMed:3002707 ]
  11. Baynes J, Levine M: Urea-extractable protein from human epidermis. Biochim Biophys Acta. 1976 Jul 19;439(1):107-15. [PubMed:952948 ]
  12. Shishu, Singla AK, Kaur IP: Inhibitory effect of dibenzoylmethane on mutagenicity of food-derived heterocyclic amine mutagens. Phytomedicine. 2003;10(6-7):575-82. [PubMed:13678246 ]
  13. Caccuri AM, Ascenzi P, Lo Bello M, Federici G, Battistoni A, Mazzetti P, Ricci G: Are the steady state kinetics of glutathione transferase always dependent on the deprotonation of the bound glutathione? New insights in the kinetic mechanism of GST P 1-1. Biochem Biophys Res Commun. 1994 May 16;200(3):1428-34. [PubMed:8185596 ]
  14. Vanden Bossche H, Marichal P, Gorrens J, Coene MC, Willemsens G, Bellens D, Roels I, Moereels H, Janssen PA: Biochemical approaches to selective antifungal activity. Focus on azole antifungals. Mycoses. 1989;32 Suppl 1:35-52. [PubMed:2561184 ]
  15. Smith DP, Smith DG, Curtain CC, Boas JF, Pilbrow JR, Ciccotosto GD, Lau TL, Tew DJ, Perez K, Wade JD, Bush AI, Drew SC, Separovic F, Masters CL, Cappai R, Barnham KJ: Copper-mediated amyloid-beta toxicity is associated with an intermolecular histidine bridge. J Biol Chem. 2006 Jun 2;281(22):15145-54. Epub 2006 Apr 4. [PubMed:16595673 ]

Enzymes

General function:
Involved in oxidoreductase activity
Specific function:
Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. Also has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such COX2.
Gene Name:
NOS2
Uniprot ID:
P35228
Molecular weight:
131116.3
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
General function:
Involved in binding
Specific function:
Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity.
Gene Name:
LTA4H
Uniprot ID:
P09960
Molecular weight:
69284.64
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
General function:
Involved in protein kinase activity
Specific function:
May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Isoform 2 promotes the G1/S transition of the cell cycle via up-regulation of CDK2 activity and phosphorylation of CDKN1B, resulting in enhanced nuclear export and proteasome-dependent degradation of CDKN1B. Isoform 2 also represses CDKN1B transcription by phosphorylating and inactivating the transcription factor FOXO3. Plays a role in signal transduction in blood cells. Contributes to both cell proliferation and survival and thus provides a selective advantage in tumorigenesis
Gene Name:
PIM1
Uniprot ID:
P11309
Molecular weight:
45411.9
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
General function:
Involved in iron ion binding
Specific function:
Plays a role in apoptosis. Suppression of the anti- apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases
Gene Name:
CYCS
Uniprot ID:
P99999
Molecular weight:
11748.7
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
General function:
Involved in iron ion binding
Specific function:
Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles
Gene Name:
MB
Uniprot ID:
P02144
Molecular weight:
17183.7
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
General function:
Involved in Mo-molybdopterin cofactor biosynthetic process
Specific function:
Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.
Gene Name:
GPHN
Uniprot ID:
Q9NQX3
Molecular weight:
79747.635
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]
General function:
Involved in ATP binding
Specific function:
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in energy metabolism and nucleotide synthesis that is essential for maintenance and cell growth. Plays a key role in hematopoiesis.
Gene Name:
AK2
Uniprot ID:
P54819
Molecular weight:
24648.125
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
  3. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]