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Record Information
Version5.0
StatusExpected but not Quantified
Creation Date2012-09-11 17:33:12 UTC
Update Date2021-10-13 06:03:48 UTC
HMDB IDHMDB0029878
Secondary Accession Numbers
  • HMDB29878
Metabolite Identification
Common NameD-Tartaric acid
DescriptionD-Tartaric acid, also known as (S,S)-tartrate or D-threaric acid, belongs to the class of organic compounds known as sugar acids and derivatives. Sugar acids and derivatives are compounds containing a saccharide unit which bears a carboxylic acid group. D-Tartaric acid has been detected, but not quantified in, loquats (Eriobotrya japonica). This could make D-tartaric acid a potential biomarker for the consumption of these foods. D-Tartaric acid is a secondary metabolite. Secondary metabolites are metabolically or physiologically non-essential metabolites that may serve a role as defense or signalling molecules. In some cases they are simply molecules that arise from the incomplete metabolism of other secondary metabolites. Based on a literature review very few articles have been published on D-Tartaric acid.
Structure
Data?1563861905
Synonyms
ValueSource
(-)-(S,S)-Tartaric acidChEBI
(-)-D-Tartaric acidChEBI
(-)-Tartaric acidChEBI
(-)-WeinsaeureChEBI
(2S,3S)-(-)-Tartaric acidChEBI
(2S,3S)-Tartaric acidChEBI
(S,S)-(-)-Tartaric acidChEBI
(S,S)-Tartaric acidChEBI
D(-)-TARTARIC ACIDChEBI
D-(-)-Tartaric acidChEBI
D-Threaric acidChEBI
LinksweinsaeureChEBI
(S,S)-TartrateKegg
D-TartrateKegg
(-)-(S,S)-TartarateGenerator
(-)-D-TartarateGenerator
(-)-TartarateGenerator
(2S,3S)-(-)-TartarateGenerator
(2S,3S)-TartarateGenerator
(S,S)-(-)-TartarateGenerator
(S,S)-TartarateGenerator
D(-)-TARTARateGenerator
D-(-)-TartarateGenerator
D-ThrearateGenerator
(S,S)-Tartric acidGenerator
D-Tartric acidGenerator
D-TartarateGenerator
(2S,3S)-2,3-Dihydroxybutanedioic acidHMDB
TartrateHMDB
Calcium tartrateMeSH
Tartaric acid, ((r*,r*)-(+-))-isomerMeSH
(R*,r*)-(+-)-2,3-dihydroxybutanedioic acid, monoammonium monosodium saltMeSH
Aluminum tartrateMeSH
Sodium ammonium tartrateMeSH
Tartaric acid, (R-(r*,r*))-isomerMeSH
Tartaric acid, (S-(r*,r*))-isomerMeSH
Ammonium tartrateMeSH
Calcium tartrate tetrahydrateMeSH
Potassium tartrateMeSH
Seignette saltMeSH
Sodium potassium tartrateMeSH
Stannous tartrateMeSH
Tartaric acidMeSH
Tartaric acid, (r*,s*)-isomerMeSH
Tartaric acid, ammonium sodium salt, (1:1:1) salt, (r*,r*)-(+-)-isomerMeSH
Tartaric acid, calcium salt, (R-r*,r*)-isomerMeSH
MN(III) tartrateMeSH
Sodium tartrateMeSH
Tartaric acid, monoammonium salt, (R-(r*,r*))-isomerMeSH
Chemical FormulaC4H6O6
Average Molecular Weight150.0868
Monoisotopic Molecular Weight150.016437924
IUPAC Name(2S,3S)-2,3-dihydroxybutanedioic acid
Traditional NameD-tartaric acid
CAS Registry Number147-71-7
SMILES
O[C@@H]([C@H](O)C(O)=O)C(O)=O
InChI Identifier
InChI=1S/C4H6O6/c5-1(3(7)8)2(6)4(9)10/h1-2,5-6H,(H,7,8)(H,9,10)/t1-,2-/m0/s1
InChI KeyFEWJPZIEWOKRBE-LWMBPPNESA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as sugar acids and derivatives. Sugar acids and derivatives are compounds containing a saccharide unit which bears a carboxylic acid group.
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentSugar acids and derivatives
Alternative Parents
Substituents
  • Beta-hydroxy acid
  • Short-chain hydroxy acid
  • Sugar acid
  • Monosaccharide
  • Hydroxy acid
  • Dicarboxylic acid or derivatives
  • Alpha-hydroxy acid
  • Fatty acid
  • Secondary alcohol
  • 1,2-diol
  • Carboxylic acid
  • Carboxylic acid derivative
  • Alcohol
  • Carbonyl group
  • Hydrocarbon derivative
  • Organic oxide
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Route of exposure

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point169 - 170 °CNot Available
Boiling Point399.26 °C. @ 760.00 mm Hg (est)The Good Scents Company Information System
Water Solubility1000000 mg/L @ 25 °C (exp)The Good Scents Company Information System
LogP-1.081 (est)The Good Scents Company Information System
Experimental Chromatographic Properties

Experimental Collision Cross Sections

Adduct TypeData SourceCCS Value (Å2)Reference
[M-H]-Not Available117.95http://allccs.zhulab.cn/database/detail?ID=AllCCS00002180
Predicted Molecular Properties
PropertyValueSource
Water Solubility161 g/LALOGPS
logP10(-1.3) g/LALOGPS
logP10(-1.8) g/LChemAxon
logS10(0.03) g/LALOGPS
pKa (Strongest Acidic)2.72ChemAxon
pKa (Strongest Basic)-4.3ChemAxon
Physiological Charge-2ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area115.06 ŲChemAxon
Rotatable Bond Count3ChemAxon
Refractivity26.21 m³·mol⁻¹ChemAxon
Polarizability11.61 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+130.32831661259
DarkChem[M-H]-126.77631661259

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
D-Tartaric acidO[C@@H]([C@H](O)C(O)=O)C(O)=O2468.8Standard polar33892256
D-Tartaric acidO[C@@H]([C@H](O)C(O)=O)C(O)=O1229.6Standard non polar33892256
D-Tartaric acidO[C@@H]([C@H](O)C(O)=O)C(O)=O1414.4Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
D-Tartaric acid,1TMS,isomer #1C[Si](C)(C)O[C@H](C(=O)O)[C@H](O)C(=O)O1393.8Semi standard non polar33892256
D-Tartaric acid,1TMS,isomer #2C[Si](C)(C)OC(=O)[C@@H](O)[C@H](O)C(=O)O1372.7Semi standard non polar33892256
D-Tartaric acid,2TMS,isomer #1C[Si](C)(C)OC(=O)[C@@H](O[Si](C)(C)C)[C@H](O)C(=O)O1459.4Semi standard non polar33892256
D-Tartaric acid,2TMS,isomer #2C[Si](C)(C)O[C@H](C(=O)O)[C@H](O[Si](C)(C)C)C(=O)O1490.2Semi standard non polar33892256
D-Tartaric acid,2TMS,isomer #3C[Si](C)(C)OC(=O)[C@@H](O)[C@H](O[Si](C)(C)C)C(=O)O1471.2Semi standard non polar33892256
D-Tartaric acid,2TMS,isomer #4C[Si](C)(C)OC(=O)[C@@H](O)[C@H](O)C(=O)O[Si](C)(C)C1461.5Semi standard non polar33892256
D-Tartaric acid,3TMS,isomer #1C[Si](C)(C)OC(=O)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)O1549.0Semi standard non polar33892256
D-Tartaric acid,3TMS,isomer #2C[Si](C)(C)OC(=O)[C@@H](O)[C@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C1567.0Semi standard non polar33892256
D-Tartaric acid,4TMS,isomer #1C[Si](C)(C)OC(=O)[C@@H](O[Si](C)(C)C)[C@H](O[Si](C)(C)C)C(=O)O[Si](C)(C)C1665.8Semi standard non polar33892256
D-Tartaric acid,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)O[C@H](C(=O)O)[C@H](O)C(=O)O1670.2Semi standard non polar33892256
D-Tartaric acid,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@@H](O)[C@H](O)C(=O)O1648.3Semi standard non polar33892256
D-Tartaric acid,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O)C(=O)O1926.6Semi standard non polar33892256
D-Tartaric acid,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@H](C(=O)O)[C@H](O[Si](C)(C)C(C)(C)C)C(=O)O1947.7Semi standard non polar33892256
D-Tartaric acid,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC(=O)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)C(=O)O1944.5Semi standard non polar33892256
D-Tartaric acid,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC(=O)[C@@H](O)[C@H](O)C(=O)O[Si](C)(C)C(C)(C)C1914.7Semi standard non polar33892256
D-Tartaric acid,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)C(=O)O2219.8Semi standard non polar33892256
D-Tartaric acid,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(=O)[C@@H](O)[C@H](O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C2201.9Semi standard non polar33892256
D-Tartaric acid,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC(=O)[C@@H](O[Si](C)(C)C(C)(C)C)[C@H](O[Si](C)(C)C(C)(C)C)C(=O)O[Si](C)(C)C(C)(C)C2425.8Semi standard non polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - D-Tartaric acid GC-MS (Non-derivatized) - 70eV, Positivesplash10-00dl-9100000000-8bde7767994dfa024f042017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - D-Tartaric acid GC-MS (4 TMS) - 70eV, Positivesplash10-00di-8029100000-283552abf9161a3491362017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - D-Tartaric acid GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - D-Tartaric acid LC-ESI-QTOF , negative-QTOFsplash10-000b-7900000000-726ac5a26ac0040576be2017-09-14HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - D-Tartaric acid 20V, Negative-QTOFsplash10-0596-9000000000-698b74eb297da7ed080a2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - D-Tartaric acid 40V, Negative-QTOFsplash10-0007-9000000000-e954c3d69ce9d53ebf7d2021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - D-Tartaric acid 10V, Negative-QTOFsplash10-000j-9400000000-80b5d59532138e72b9952021-09-20HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - D-Tartaric acid 35V, Negative-QTOFsplash10-0072-9600000000-9aade42ff2130e4897432021-09-20HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 10V, Positive-QTOFsplash10-0ue9-1900000000-6a73140cfa5a0c0234e32016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 20V, Positive-QTOFsplash10-056r-9600000000-ca8758d1e65f5dbe35d92016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 40V, Positive-QTOFsplash10-0a70-9100000000-1630b812321816f95d112016-06-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 10V, Negative-QTOFsplash10-05bb-7900000000-146a1c7b189a7bbacda02016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 20V, Negative-QTOFsplash10-0a4i-9500000000-f7af07684007cf14bdce2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 40V, Negative-QTOFsplash10-0a4i-9000000000-a8f5502da9e4d13e41442016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 10V, Negative-QTOFsplash10-0a4s-4900000000-4b81a8a41abed679d1342021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 20V, Negative-QTOFsplash10-0a4i-9200000000-b73e0df104053da762682021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 40V, Negative-QTOFsplash10-052f-9000000000-4d8ce26149e6d7a8763f2021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 10V, Positive-QTOFsplash10-05o0-3900000000-e52d00e2e7427df264f92021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 20V, Positive-QTOFsplash10-05p9-9300000000-1e180faafcb2fce141022021-09-24Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - D-Tartaric acid 40V, Positive-QTOFsplash10-0bt9-9000000000-254ae2874ffc06d5337a2021-09-24Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-30Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
  • Extracellular
Biospecimen LocationsNot Available
Tissue LocationsNot Available
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB001110
KNApSAcK IDNot Available
Chemspider ID388726
KEGG Compound IDC02107
BioCyc IDD-TARTRATE
BiGG IDNot Available
Wikipedia LinkTartaric acid
METLIN IDNot Available
PubChem Compound439655
PDB IDTAR
ChEBI ID15672
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDrw1060801
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. (). Yannai, Shmuel. (2004) Dictionary of food compounds with CD-ROM: Additives, flavors, and ingredients. Boca Raton: Chapman & Hall/CRC.. .

Enzymes

General function:
Involved in galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity
Specific function:
Involved in the biosynthesis of L2/HNK-1 carbohydrate epitope on glycoproteins. Can also play a role in glycosaminoglycan biosynthesis. Substrates include asialo-orosomucoid (ASOR), asialo-fetuin, and asialo-neural cell adhesion molecule. Requires sphingomyelin for activity: stearoyl-sphingomyelin was the most effective, followed by palmitoyl-sphingomyelin and lignoceroyl-sphingomyelin. Activity was demonstrated only for sphingomyelin with a saturated fatty acid and not for that with an unsaturated fatty acid, regardless of the length of the acyl group (By similarity).
Gene Name:
B3GAT1
Uniprot ID:
Q9P2W7
Molecular weight:
38255.675
References
  1. Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
  2. Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
General function:
Involved in metal ion binding
Specific function:
Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Gene Name:
HIF1AN
Uniprot ID:
Q9NWT6
Molecular weight:
40285.25
General function:
Involved in hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Specific function:
Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells
Gene Name:
ATP6V1C1
Uniprot ID:
P21283
Molecular weight:
43941.2
References
  1. Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. [PubMed:10592235 ]