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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2005-11-16 15:48:42 UTC
Update Date2021-09-14 15:44:40 UTC
HMDB IDHMDB0000497
Secondary Accession Numbers
  • HMDB00497
Metabolite Identification
Common Name5,6-Dihydrouridine
Description5,6-Dihydrouridine belongs to the class of organic compounds known as glycosylamines. Glycosylamines are compounds consisting of an amine with a beta-N-glycosidic bond to a carbohydrate, thus forming a cyclic hemiaminal ether bond (alpha-amino ether). 5,6-Dihydrouridine has been detected, but not quantified in, a few different foods, such as anatidaes (Anatidae), chickens (Gallus gallus), and domestic pigs (Sus scrofa domestica). This could make 5,6-dihydrouridine a potential biomarker for the consumption of these foods. Based on a literature review a significant number of articles have been published on 5,6-Dihydrouridine.
Structure
Data?1582752135
Synonyms
ValueSource
1-beta-D-RibofuranosylhydrouracilChEBI
3,4-DihydrouridineChEBI
DChEBI
1-b-D-RibofuranosylhydrouracilGenerator
1-Β-D-ribofuranosylhydrouracilGenerator
Dihydro-1-b-D-ribofuranosyl-2,4(1H,3H)-pyrimidinedioneHMDB
Dihydro-1-beta-delta-ribofuranosyl-2,4(1H,3H)-pyrimidinedioneHMDB
DihydrouridineHMDB
5,6-DihydrouridineMeSH
Chemical FormulaC9H14N2O6
Average Molecular Weight246.2173
Monoisotopic Molecular Weight246.08518619
IUPAC Name1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1,3-diazinane-2,4-dione
Traditional Namedihydrouridine
CAS Registry Number5627-05-4
SMILES
OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1CCC(=O)NC1=O
InChI Identifier
InChI=1S/C9H14N2O6/c12-3-4-6(14)7(15)8(17-4)11-2-1-5(13)10-9(11)16/h4,6-8,12,14-15H,1-3H2,(H,10,13,16)/t4-,6-,7-,8-/m1/s1
InChI KeyZPTBLXKRQACLCR-XVFCMESISA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as glycosylamines. Glycosylamines are compounds consisting of an amine with a beta-N-glycosidic bond to a carbohydrate, thus forming a cyclic hemiaminal ether bond (alpha-amino ether).
KingdomOrganic compounds
Super ClassOrganic oxygen compounds
ClassOrganooxygen compounds
Sub ClassCarbohydrates and carbohydrate conjugates
Direct ParentGlycosylamines
Alternative Parents
Substituents
  • N-glycosyl compound
  • Pentose monosaccharide
  • Pyrimidone
  • Hydropyrimidine
  • 1,2,5,6-tetrahydropyrimidine
  • Monosaccharide
  • Pyrimidine
  • Tetrahydrofuran
  • Secondary alcohol
  • Carbonic acid derivative
  • Organic 1,3-dipolar compound
  • Propargyl-type 1,3-dipolar organic compound
  • Oxacycle
  • Azacycle
  • Organoheterocyclic compound
  • Hydrocarbon derivative
  • Organonitrogen compound
  • Organopnictogen compound
  • Carbonyl group
  • Alcohol
  • Primary alcohol
  • Organic nitrogen compound
  • Organic oxide
  • Aliphatic heteromonocyclic compound
Molecular FrameworkAliphatic heteromonocyclic compounds
External Descriptors
Ontology
Disposition

Biological location

Source

Route of exposure

Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility231 g/LALOGPS
logP10(-2.1) g/LALOGPS
logP10(-2.8) g/LChemAxon
logS10(-0.03) g/LALOGPS
pKa (Strongest Acidic)11.59ChemAxon
pKa (Strongest Basic)-3ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count6ChemAxon
Hydrogen Donor Count4ChemAxon
Polar Surface Area119.33 ŲChemAxon
Rotatable Bond Count2ChemAxon
Refractivity52.34 m³·mol⁻¹ChemAxon
Polarizability22.98 ųChemAxon
Number of Rings2ChemAxon
BioavailabilityYesChemAxon
Rule of FiveYesChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+155.18831661259
DarkChem[M-H]-151.48931661259
AllCCS[M+H]+155.28832859911
AllCCS[M-H]-153.25432859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
5,6-DihydrouridineOC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1CCC(=O)NC1=O3804.3Standard polar33892256
5,6-DihydrouridineOC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1CCC(=O)NC1=O2258.7Standard non polar33892256
5,6-DihydrouridineOC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1CCC(=O)NC1=O2303.8Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
5,6-Dihydrouridine,1TMS,isomer #1C[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)NC2=O)[C@H](O)[C@@H]1O2294.7Semi standard non polar33892256
5,6-Dihydrouridine,1TMS,isomer #2C[Si](C)(C)O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1CCC(=O)NC1=O2321.5Semi standard non polar33892256
5,6-Dihydrouridine,1TMS,isomer #3C[Si](C)(C)O[C@@H]1[C@@H](CO)O[C@@H](N2CCC(=O)NC2=O)[C@@H]1O2318.6Semi standard non polar33892256
5,6-Dihydrouridine,1TMS,isomer #4C[Si](C)(C)N1C(=O)CCN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C1=O2265.9Semi standard non polar33892256
5,6-Dihydrouridine,2TMS,isomer #1C[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)NC2=O)[C@H](O[Si](C)(C)C)[C@@H]1O2350.5Semi standard non polar33892256
5,6-Dihydrouridine,2TMS,isomer #2C[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)NC2=O)[C@H](O)[C@@H]1O[Si](C)(C)C2336.1Semi standard non polar33892256
5,6-Dihydrouridine,2TMS,isomer #3C[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C)C2=O)[C@H](O)[C@@H]1O2272.9Semi standard non polar33892256
5,6-Dihydrouridine,2TMS,isomer #4C[Si](C)(C)O[C@@H]1[C@@H](CO)O[C@@H](N2CCC(=O)NC2=O)[C@@H]1O[Si](C)(C)C2347.9Semi standard non polar33892256
5,6-Dihydrouridine,2TMS,isomer #5C[Si](C)(C)O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1CCC(=O)N([Si](C)(C)C)C1=O2245.3Semi standard non polar33892256
5,6-Dihydrouridine,2TMS,isomer #6C[Si](C)(C)O[C@@H]1[C@@H](CO)O[C@@H](N2CCC(=O)N([Si](C)(C)C)C2=O)[C@@H]1O2258.4Semi standard non polar33892256
5,6-Dihydrouridine,3TMS,isomer #1C[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)NC2=O)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2350.1Semi standard non polar33892256
5,6-Dihydrouridine,3TMS,isomer #2C[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C)C2=O)[C@H](O[Si](C)(C)C)[C@@H]1O2279.2Semi standard non polar33892256
5,6-Dihydrouridine,3TMS,isomer #3C[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C)C2=O)[C@H](O)[C@@H]1O[Si](C)(C)C2270.4Semi standard non polar33892256
5,6-Dihydrouridine,3TMS,isomer #4C[Si](C)(C)O[C@@H]1[C@@H](CO)O[C@@H](N2CCC(=O)N([Si](C)(C)C)C2=O)[C@@H]1O[Si](C)(C)C2258.5Semi standard non polar33892256
5,6-Dihydrouridine,4TMS,isomer #1C[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C)C2=O)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2286.8Semi standard non polar33892256
5,6-Dihydrouridine,4TMS,isomer #1C[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C)C2=O)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2470.2Standard non polar33892256
5,6-Dihydrouridine,4TMS,isomer #1C[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C)C2=O)[C@H](O[Si](C)(C)C)[C@@H]1O[Si](C)(C)C2772.9Standard polar33892256
5,6-Dihydrouridine,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)NC2=O)[C@H](O)[C@@H]1O2532.6Semi standard non polar33892256
5,6-Dihydrouridine,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1CCC(=O)NC1=O2543.3Semi standard non polar33892256
5,6-Dihydrouridine,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](CO)O[C@@H](N2CCC(=O)NC2=O)[C@@H]1O2536.7Semi standard non polar33892256
5,6-Dihydrouridine,1TBDMS,isomer #4CC(C)(C)[Si](C)(C)N1C(=O)CCN([C@@H]2O[C@H](CO)[C@@H](O)[C@H]2O)C1=O2503.0Semi standard non polar33892256
5,6-Dihydrouridine,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)NC2=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O2767.9Semi standard non polar33892256
5,6-Dihydrouridine,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)NC2=O)[C@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C2753.5Semi standard non polar33892256
5,6-Dihydrouridine,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C(C)(C)C)C2=O)[C@H](O)[C@@H]1O2708.1Semi standard non polar33892256
5,6-Dihydrouridine,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](CO)O[C@@H](N2CCC(=O)NC2=O)[C@@H]1O[Si](C)(C)C(C)(C)C2748.6Semi standard non polar33892256
5,6-Dihydrouridine,2TBDMS,isomer #5CC(C)(C)[Si](C)(C)O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1CCC(=O)N([Si](C)(C)C(C)(C)C)C1=O2699.9Semi standard non polar33892256
5,6-Dihydrouridine,2TBDMS,isomer #6CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](CO)O[C@@H](N2CCC(=O)N([Si](C)(C)C(C)(C)C)C2=O)[C@@H]1O2702.9Semi standard non polar33892256
5,6-Dihydrouridine,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)NC2=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C3004.3Semi standard non polar33892256
5,6-Dihydrouridine,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C(C)(C)C)C2=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O2940.8Semi standard non polar33892256
5,6-Dihydrouridine,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C(C)(C)C)C2=O)[C@H](O)[C@@H]1O[Si](C)(C)C(C)(C)C2935.0Semi standard non polar33892256
5,6-Dihydrouridine,3TBDMS,isomer #4CC(C)(C)[Si](C)(C)O[C@@H]1[C@@H](CO)O[C@@H](N2CCC(=O)N([Si](C)(C)C(C)(C)C)C2=O)[C@@H]1O[Si](C)(C)C(C)(C)C2921.7Semi standard non polar33892256
5,6-Dihydrouridine,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C(C)(C)C)C2=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C3155.4Semi standard non polar33892256
5,6-Dihydrouridine,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C(C)(C)C)C2=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C3323.9Standard non polar33892256
5,6-Dihydrouridine,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OC[C@H]1O[C@@H](N2CCC(=O)N([Si](C)(C)C(C)(C)C)C2=O)[C@H](O[Si](C)(C)C(C)(C)C)[C@@H]1O[Si](C)(C)C(C)(C)C3101.4Standard polar33892256
Spectra

GC-MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (Non-derivatized) - 70eV, Positivesplash10-0a4i-9630000000-15e433fd50f5283e7c702017-09-01Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (3 TMS) - 70eV, Positivesplash10-0fa2-5977600000-2e6dc8e47acc572f91e72017-10-06Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (Non-derivatized) - 70eV, PositiveNot Available2021-10-12Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_1_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_1_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_1_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_1_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_2_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_2_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_2_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_2_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_2_5) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_2_6) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_3_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_3_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TMS_3_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TBDMS_1_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TBDMS_1_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TBDMS_1_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TBDMS_1_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TBDMS_2_1) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TBDMS_2_2) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TBDMS_2_3) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum
Predicted GC-MSPredicted GC-MS Spectrum - 5,6-Dihydrouridine GC-MS (TBDMS_2_4) - 70eV, PositiveNot Available2021-11-05Wishart LabView Spectrum

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 10V, Positive-QTOFsplash10-014i-1920000000-6709bfe12a99399905ae2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 20V, Positive-QTOFsplash10-014i-8900000000-8c868a51dd1b65e8911f2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 40V, Positive-QTOFsplash10-014m-9500000000-65ec5beb0c86d7c307b32016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 10V, Negative-QTOFsplash10-01ot-2690000000-33fe0d39759c168982352016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 20V, Negative-QTOFsplash10-0006-9100000000-bb26ee994aafc4e96a2e2016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 40V, Negative-QTOFsplash10-0006-9100000000-4c20e49ada219697c1542016-08-03Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 10V, Positive-QTOFsplash10-014i-0920000000-4ef817592c10e76e901d2021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 20V, Positive-QTOFsplash10-014i-2920000000-e1ff0efd002a4870b8d22021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 40V, Positive-QTOFsplash10-01b9-9700000000-c671b5ded8fa9d4e67342021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 10V, Negative-QTOFsplash10-01r2-0590000000-4d20d79523dcba08b44a2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 20V, Negative-QTOFsplash10-0hfw-4940000000-4e7d076c3dc715e35ccf2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - 5,6-Dihydrouridine 40V, Negative-QTOFsplash10-0006-9200000000-d9747b2acc3e65b6ad8c2021-09-23Wishart LabView Spectrum

NMR Spectra

Spectrum TypeDescriptionDeposition DateSourceView
Predicted 1D NMR1H NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 100 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 200 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 300 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 400 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 500 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 600 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 700 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 800 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 900 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR1H NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Predicted 1D NMR13C NMR Spectrum (1D, 1000 MHz, D2O, predicted)2021-09-16Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Cytoplasm
Biospecimen Locations
  • Blood
  • Urine
Tissue LocationsNot Available
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodExpected but not QuantifiedNot QuantifiedNot AvailableNot Available
Normal
      Not Available
details
UrineDetected and Quantified6.37 +/- 1.38 umol/mmol creatinineAdult (>18 years old)BothNormal details
UrineDetected and Quantified7.03 +/- 1.31 umol/mmol creatinineAdult (>18 years old)FemaleNormal details
UrineDetected and Quantified5.83 +/- 1.22 umol/mmol creatinineAdult (>18 years old)MaleNormal details
Abnormal Concentrations
Not Available
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB022076
KNApSAcK IDNot Available
Chemspider ID85115
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkDihydrouridine
METLIN ID5483
PubChem Compound94312
PDB IDNot Available
ChEBI ID23774
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceCerutti, Peter; Kondo, Yoshikazu; Landis, W. R.; Witkop, Bernhard. Photoreduction of uridine and reduction of dihydrouridine with sodium borohydride. Journal of the American Chemical Society (1968), 90(3), 771-5.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Liebich HM, Di Stefano C, Wixforth A, Schmid HR: Quantitation of urinary nucleosides by high-performance liquid chromatography. J Chromatogr A. 1997 Feb 28;763(1-2):193-7. [PubMed:9129323 ]
  2. Reimer ML, Schram KH, Nakano K, Yasaka T: The identification of 5,6-dihydrouridine in normal human urine by combined gas chromatography/mass spectrometry. Anal Biochem. 1989 Sep;181(2):302-8. [PubMed:2817393 ]
  3. Topp H, Duden R, Schoch G: 5,6-Dihydrouridine: a marker ribonucleoside for determining whole body degradation rates of transfer RNA in man and rats. Clin Chim Acta. 1993 Sep 17;218(1):73-82. [PubMed:8299222 ]

Enzymes

General function:
Involved in catalytic activity
Specific function:
Dihydrouridine synthase. Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs
Gene Name:
DUS2L
Uniprot ID:
Q9NX74
Molecular weight:
55049.8
General function:
Involved in catalytic activity
Specific function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs
Gene Name:
DUS1L
Uniprot ID:
Q6P1R4
Molecular weight:
53230.0
General function:
Involved in catalytic activity
Specific function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs
Gene Name:
DUS3L
Uniprot ID:
Q96G46
Molecular weight:
72593.3
General function:
Involved in catalytic activity
Specific function:
Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs
Gene Name:
DUS4L
Uniprot ID:
O95620
Molecular weight:
35816.2
General function:
Involved in catalytic activity
Specific function:
Not Available
Gene Name:
PP35
Uniprot ID:
A4D0R5
Molecular weight:
35816.2