Showing metabocard for beta-D-Galactose (HMDB0003449)

General function:

Involved in oxidoreductase activity

Specific function:

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Gene Name:

AKR1B1

Uniprot ID:

P15121

Molecular weight:

35853.125

Reactions

General function:

Involved in galactosylceramidase activity

Specific function:

Hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Enzyme with very low activity responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon.

Gene Name:

GALC

Uniprot ID:

P54803

Molecular weight:

77062.86

Reactions

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

LPH splits lactose in the small intestine.

Gene Name:

LCT

Uniprot ID:

P09848

Molecular weight:

218584.77

Reactions

General function:

Involved in catalytic activity

Specific function:

Not Available

Gene Name:

GLA

Uniprot ID:

P06280

Molecular weight:

Not Available

Reactions

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Cleaves beta-linked terminal galactosyl residues from gangliosides, glycoproteins, and glycosaminoglycans. Isoform 2 has no beta-galactosidase catalytic activity, but plays functional roles in the formation of extracellular elastic fibers (elastogenesis) and in the development of connective tissue. Seems to be identical to the elastin-binding protein (EBP), a major component of the non-integrin cell surface receptor expressed on fibroblasts, smooth muscle cells, chondroblasts, leukocytes, and certain cancer cell types. In elastin producing cells, associates with tropoelastin intracellularly and functions as a recycling molecular chaperone which facilitates the secretions of tropoelastin and its assembly into elastic fibers.

Gene Name:

GLB1

Uniprot ID:

P16278

Molecular weight:

Not Available

Reactions

General function:

Involved in galactokinase activity

Specific function:

Acts on GalNAc. Also acts as a galactokinase when galactose is present at high concentrations. May be involved in a salvage pathway for the reutilization of free GalNAc derived from the degradation of complex carbohydrates.

Gene Name:

GALK2

Uniprot ID:

Q01415

Molecular weight:

49234.57

Reactions

General function:

Involved in galactokinase activity

Specific function:

Major enzyme for galactose metabolism.

Gene Name:

GALK1

Uniprot ID:

P51570

Molecular weight:

42271.805

Reactions

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Hydrolysis of terminal non-reducing beta-D- galactose residues in beta-D-galactosides

Gene Name:

Not Available

Uniprot ID:

Q53H18

Molecular weight:

76109.2

General function:

Involved in hydrolase activity, hydrolyzing O-glycosyl compounds

Specific function:

Hydrolysis of terminal non-reducing beta-D- galactose residues in beta-D-galactosides

Gene Name:

Not Available

Uniprot ID:

Q53G40

Molecular weight:

76068.2

General function:

Not Available

Specific function:

Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs.

Gene Name:

AKR1B10

Uniprot ID:

O60218

Molecular weight:

Not Available

Reactions