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Record Information
Version5.0
StatusDetected and Quantified
Creation Date2008-09-12 01:31:59 UTC
Update Date2022-03-07 02:50:03 UTC
HMDB IDHMDB0008138
Secondary Accession Numbers
  • HMDB08138
Metabolite Identification
Common NamePC(18:2(9Z,12Z)/18:2(9Z,12Z))
DescriptionPC(18:2(9Z,12Z)/18:2(9Z,12Z)) is a phosphatidylcholine (PC or GPCho). It is a glycerophospholipid in which a phosphorylcholine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphocholines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PC(18:2(9Z,12Z)/18:2(9Z,12Z)), in particular, consists of two chains of linoleic acid at the C-1 and C-2 positions. The linoleic acid moieties are derived from seed oils. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling.While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PCs can be synthesized via three different routes. In one route, choline is activated first by phosphorylation and then by coupling to CDP prior to attachment to phosphatidic acid. PCs can also synthesized by the addition of choline to CDP-activated 1,2-diacylglycerol. A third route to PC synthesis involves the conversion of either PS or PE to PC.
Structure
Data?1582752540
Synonyms
ValueSource
(2R)-2,3-Bis[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl 2-(trimethylammonio)ethyl phosphateChEBI
(2R)-2,3-Bis{[(9Z,12Z)-octadeca-9,12-dienoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphateChEBI
1,2-Di-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholineChEBI
1,2-Di-O-linoleoyl-sn-glycero-3-phosphocholineChEBI
1,2-Dilinoleoyl-sn-glycero-3-phosphocholineChEBI
DI-linoleoyl-3-sn-phosphatidylcholineChEBI
DilinoleoylphosphatidylcholineChEBI
DL-PCChEBI
DLNPCChEBI
DLPCChEBI
GPCho(18:2/18:2)ChEBI
GPCho(18:2n6/18:2n6)ChEBI
GPCho(18:2W6/18:2W6)ChEBI
L-DilinoleoyllecithinChEBI
PC(18:2/18:2)ChEBI
PC(18:2n6/18:2n6)ChEBI
PC(18:2W6/18:2W6)ChEBI
Phosphatidylcholine(18:2/18:2)ChEBI
Phosphatidylcholine(18:2n6/18:2n6)ChEBI
Phosphatidylcholine(18:2W6/18:2W6)ChEBI
(2R)-2,3-Bis[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl 2-(trimethylammonio)ethyl phosphoric acidGenerator
(2R)-2,3-Bis{[(9Z,12Z)-octadeca-9,12-dienoyl]oxy}propyl 2-(trimethylazaniumyl)ethyl phosphoric acidGenerator
1,2-Linoleoylphosphatidylcholine, 14C-labeled CPD, (R-(all Z))-isomerHMDB
1,2-Dilinoleoyl-3-glycerophosphocholineHMDB
1,2-LinoleoylphosphatidylcholineHMDB
DLPC LipidHMDB
DilinoleoyllecithinHMDB
Dilinoleoyl phosphatidylcholineHMDB
1,2-Linoleoyl-sn-glycero-3-phosphocholineHMDB
1,2-Linoleoylphosphatidylcholine, (R-(all Z))-isomerHMDB
Phosphatidylcholine(36:4)HMDB
LecithinHMDB
PC(36:4)HMDB
1,2-Dilinoleoyl-rac-glycero-3-phosphocholineHMDB
1,2-Di(9Z,12Z-octadecadienoyl)-rac-glycero-3-phosphocholineHMDB
GPCho(36:4)HMDB
1,2-Dilinoleoyl-GPCHMDB
PC(18:2(9Z,12Z)/18:2(9Z,12Z))Lipid Annotator
Chemical FormulaC44H80NO8P
Average Molecular Weight782.0817
Monoisotopic Molecular Weight781.562155053
IUPAC Name(2-{[(2R)-2,3-bis[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl phosphono]oxy}ethyl)trimethylazanium
Traditional Name(2-{[(2R)-2,3-bis[(9Z,12Z)-octadeca-9,12-dienoyloxy]propyl phosphono]oxy}ethyl)trimethylazanium
CAS Registry Number998-06-1
SMILES
CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC
InChI Identifier
InChI=1S/C44H80NO8P/c1-6-8-10-12-14-16-18-20-22-24-26-28-30-32-34-36-43(46)50-40-42(41-52-54(48,49)51-39-38-45(3,4)5)53-44(47)37-35-33-31-29-27-25-23-21-19-17-15-13-11-9-7-2/h14-17,20-23,42H,6-13,18-19,24-41H2,1-5H3/b16-14-,17-15-,22-20-,23-21-/t42-/m1/s1
InChI KeyFVXDQWZBHIXIEJ-LNDKUQBDSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as phosphatidylcholines. These are glycerophosphocholines in which the two free -OH are attached to one fatty acid each through an ester linkage.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphocholines
Direct ParentPhosphatidylcholines
Alternative Parents
Substituents
  • Diacylglycero-3-phosphocholine
  • Phosphocholine
  • Fatty acid ester
  • Dialkyl phosphate
  • Dicarboxylic acid or derivatives
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Alkyl phosphate
  • Fatty acyl
  • Quaternary ammonium salt
  • Tetraalkylammonium salt
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Organic oxygen compound
  • Organic nitrogen compound
  • Carbonyl group
  • Organooxygen compound
  • Organonitrogen compound
  • Organic oxide
  • Organopnictogen compound
  • Amine
  • Organic salt
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External Descriptors
Ontology
Physiological effect
Disposition
Process
Naturally occurring process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility3.2e-05 g/LALOGPS
logP5.68ALOGPS
logP8.44ChemAxon
logS-7.4ALOGPS
pKa (Strongest Acidic)1.86ChemAxon
pKa (Strongest Basic)-6.7ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count4ChemAxon
Hydrogen Donor Count0ChemAxon
Polar Surface Area111.19 ŲChemAxon
Rotatable Bond Count40ChemAxon
Refractivity238.74 m³·mol⁻¹ChemAxon
Polarizability93.58 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DeepCCS[M+H]+289.54130932474
DeepCCS[M-H]-287.68530932474
DeepCCS[M-2H]-320.92330932474
DeepCCS[M+Na]+295.14730932474
AllCCS[M+H]+290.132859911
AllCCS[M+H-H2O]+290.032859911
AllCCS[M+NH4]+290.232859911
AllCCS[M+Na]+290.232859911
AllCCS[M-H]-274.532859911
AllCCS[M+Na-2H]-279.632859911
AllCCS[M+HCOO]-285.332859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
PC(18:2(9Z,12Z)/18:2(9Z,12Z))CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC5314.4Standard polar33892256
PC(18:2(9Z,12Z)/18:2(9Z,12Z))CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC4498.0Standard non polar33892256
PC(18:2(9Z,12Z)/18:2(9Z,12Z))CCCCC\C=C/C\C=C/CCCCCCCC(=O)OC[C@]([H])(COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC5088.8Semi standard non polar33892256
Spectra

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 21V, positive-QTOFsplash10-001i-0000000900-bd3ed2ff47d70cb5ac3e2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 32V, positive-QTOFsplash10-001i-0400000900-d002062176d9e1a58fcc2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 43V, positive-QTOFsplash10-001i-0900000100-1d81bafed34be0680f8b2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 54V, positive-QTOFsplash10-001i-0900000000-b42fac72a675be84234d2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 65V, positive-QTOFsplash10-001i-0900000000-a1756c5f56f420105ec62020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 76V, positive-QTOFsplash10-001i-0900000000-57ce459f0f2b4ef3b3882020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 87V, positive-QTOFsplash10-001i-1900000000-26d27e14f475fd58e1012020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 98V, positive-QTOFsplash10-001i-2900000000-ee4e32911559ac08e5692020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 109V, positive-QTOFsplash10-001i-3900000000-c96a527426c6410636622020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 131V, positive-QTOFsplash10-003i-7900000000-8fd87469bebc7841cfeb2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 164V, positive-QTOFsplash10-002s-9700000000-805c2bda88ecbe7681342020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 196V, positive-QTOFsplash10-002k-9500000000-739389c73c5b7af69f2b2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 240V, positive-QTOFsplash10-0002-9200000000-d6507de242e2b9f691192020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 286V, positive-QTOFsplash10-0002-9000000000-747c2f7f10ab5dc686cb2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) Orbitrap 351V, positive-QTOFsplash10-0002-9000000000-e963880e5dd642c7c9672020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) n/a 54V, positive-QTOFsplash10-0fe0-0000090600-6c4096785e931bdd859a2020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) n/a 54V, positive-QTOFsplash10-0006-0000900000-d438f5570e710ae02ee62020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) n/a 54V, positive-QTOFsplash10-08fr-0934000000-a2858d3a6aed2e8631802020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) n/a 54V, positive-QTOFsplash10-0udi-0300090000-e353c4c82a0a4a7c7e362020-07-22HMDB team, MONAView Spectrum
Experimental LC-MS/MSLC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) n/a 54V, positive-QTOFsplash10-000i-9200000000-b6ca8b900ee76df8ea582020-07-22HMDB team, MONAView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) 10V, Positive-QTOFsplash10-001i-0000000900-95a10c93ea7d71892a442017-10-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) 20V, Positive-QTOFsplash10-001i-0600000900-da1f205f6fe8475ad9ed2017-10-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) 40V, Positive-QTOFsplash10-001i-1900030300-707d383caeedd787dae62017-10-04Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) 10V, Negative-QTOFsplash10-001i-0000000900-2534b1e8e0eb889fbec22021-09-22Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PC(18:2(9Z,12Z)/18:2(9Z,12Z)) 20V, Negative-QTOFsplash10-003r-0080020900-5688f54205e1eea312ab2021-09-22Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
  • Feces
  • Saliva
  • Urine
Tissue Locations
  • All Tissues
  • Placenta
Pathways
Normal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified228.74(50.69) uMAdult (>18 years old)BothNormal details
BloodDetected and Quantified135 (118-151) uMNewborn (0-30 days old)Not Available
Normal
details
BloodDetected and Quantified130 (111-150) uMInfant (0-1 year old)Not Available
Normal
details
BloodDetected and Quantified189.4 +/- 38.8 uMAdult (>18 years old)BothNormal details
FecesDetected and Quantified1.26 +/- 3.87 nmol/g wet fecesAdult (>18 years old)Both
Normal
details
FecesDetected and Quantified0.85 +/- 1.04 nmol/g wet fecesAdult (>18 years old)Both
Normal
details
SalivaDetected and Quantified0.067 +/- 0.022 uMAdult (>18 years old)Both
Normal
    • Zerihun T. Dame, ...
details
UrineDetected and Quantified0.0018 (0.0005-0.0083) umol/mmol creatinineAdult (>18 years old)Both
Normal
details
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified189.52(48.48) uMAdult (>18 years old)BothHeart failure with preserved ejection fraction details
BloodDetected and Quantified185.9(31.92) uMAdult (>18 years old)BothHeart failure with reduced ejection fraction details
BloodDetected and Quantified139.129 (121.517) uMAdult (>18 years old)FemalePregnancy with fetus having congenital heart defect details
BloodDetected and Quantified260.540 (70.103) uMAdult (>18 years old)FemalePregnancy details
BloodDetected and Quantified138.6 +/- 39.6 uMChildren (1-13 years old)Both
Obesity
    • Metabolomics reve...
details
BloodDetected and Quantified159.1 +/- 43.5 uMChildren (1-13 years old)Both
Obesity
    • Metabolomics reve...
details
FecesDetected but not QuantifiedNot QuantifiedNewborn (0-30 days old)Not Specified
Premature neonates
details
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood144.872 +/- 44.844 uMAdult (>18 years old)BothNormal (Most Probable)Calculated using MetaboAnalyst
Blood479.717 +/- 119.300 uMAdult (>18 years old)BothNormal (Upper Limit)Calculated using MetaboAnalyst
Associated Disorders and Diseases
Disease References
Pregnancy
  1. Bahado-Singh RO, Ertl R, Mandal R, Bjorndahl TC, Syngelaki A, Han B, Dong E, Liu PB, Alpay-Savasan Z, Wishart DS, Nicolaides KH: Metabolomic prediction of fetal congenital heart defect in the first trimester. Am J Obstet Gynecol. 2014 Sep;211(3):240.e1-240.e14. doi: 10.1016/j.ajog.2014.03.056. Epub 2014 Apr 1. [PubMed:24704061 ]
Obesity
  1. Simone Wahl, Christina Holzapfel, Zhonghao Yu, Michaela Breier, Ivan Kondofersky, Christiane Fuchs, Paula Singmann, Cornelia Prehn, Jerzy Adamski, Harald Grallert, Thomas Illig, Rui Wang-Sattler, Thomas Reinehr (2013). Metabolomics reveals determinants of weight loss during lifestyle intervention in obese children. Metabolomics.
Associated OMIM IDs
DrugBank IDDB04372
Phenol Explorer Compound IDNot Available
FooDB IDFDB030223
KNApSAcK IDNot Available
Chemspider IDNot Available
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound5288075
PDB IDNot Available
ChEBI ID42027
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA: The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: ijms21031043. doi: 10.3390/ijms21031043. [PubMed:32033212 ]

Only showing the first 10 proteins. There are 78 proteins in total.

Enzymes

General function:
Involved in hydrolase activity
Specific function:
Hydrolyzes fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has depalmitoylating activity and also low lysophospholipase activity.
Gene Name:
LYPLA1
Uniprot ID:
O75608
Molecular weight:
24669.355
General function:
Involved in phosphatidylcholine-sterol O-acyltransferase activity
Specific function:
Has transacylase and calcium-independent phospholipase A2 activity. Catalyzes the formation of 1-O-acyl-N-acetylsphingosine and the concomitant release of a lyso-phospholipid (By similarity). May have weak lysophospholipase activity.
Gene Name:
PLA2G15
Uniprot ID:
Q8NCC3
Molecular weight:
Not Available
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
Gene Name:
PLA2G5
Uniprot ID:
P39877
Molecular weight:
15674.065
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.
Gene Name:
PLA2G2F
Uniprot ID:
Q9BZM2
Molecular weight:
23256.29
General function:
Involved in metabolic process
Specific function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Gene Name:
PLA2G4A
Uniprot ID:
P47712
Molecular weight:
85210.19
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Gene Name:
PLA2G1B
Uniprot ID:
P04054
Molecular weight:
16359.535
General function:
Involved in phospholipase A2 activity
Specific function:
Not known; does not seem to have catalytic activity.
Gene Name:
PLA2G12B
Uniprot ID:
Q9BX93
Molecular weight:
Not Available
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
Gene Name:
PLA2G10
Uniprot ID:
O15496
Molecular weight:
18153.04
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
Gene Name:
PLA2G2E
Uniprot ID:
Q9NZK7
Molecular weight:
15988.525
General function:
Involved in hydrolase activity
Specific function:
May hydrolyze fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins or HRAS. Has lysophospholipase activity (By similarity). Deacylates GAP43.
Gene Name:
LYPLA2
Uniprot ID:
O95372
Molecular weight:
24736.71

Transporters

General function:
Involved in ATP binding
Specific function:
Mediates ATP-dependent export of organic anions and drugs from the cytoplasm. Hydrolyzes ATP with low efficiency. Human MDR3 is not capable of conferring drug resistance. Mediates the translocation of phosphatidylcholine across the canalicular membrane of the hepatocyte
Gene Name:
ABCB4
Uniprot ID:
P21439
Molecular weight:
141521.8

Only showing the first 10 proteins. There are 78 proteins in total.