Hmdb loader
Record Information
Version5.0
StatusDetected but not Quantified
Creation Date2008-12-10 02:09:32 UTC
Update Date2022-11-30 19:03:58 UTC
HMDB IDHMDB0011441
Secondary Accession Numbers
  • HMDB11441
Metabolite Identification
Common NamePE(P-18:1(9Z)/18:1(9Z))
DescriptionPE(P-18:1(9Z)/18:1(9Z)) is a phosphatidylethanolamine (PE or GPEtn). It is a glycerophospholipid in which a phosphorylethanolamine moiety occupies a glycerol substitution site. As is the case with diacylglycerols, glycerophosphoethanolamines can have many different combinations of fatty acids of varying lengths and saturation attached at the C-1 and C-2 positions. Fatty acids containing 16, 18 and 20 carbons are the most common. PE(P-18:1(9Z)/18:1(9Z)), in particular, consists of one chain of plasmalogen 18:1n9 at the C-1 position and one chain of oleic acid at the C-2 position. The plasmalogen 18:1n9 moiety is derived from animal fats, liver and kidney, while the oleic acid moiety is derived from vegetable oils, especially olive and canola oil. Phospholipids, are ubiquitous in nature and are key components of the lipid bilayer of cells, as well as being involved in metabolism and signaling. While most phospholipids have a saturated fatty acid on C-1 and an unsaturated fatty acid on C-2 of the glycerol backbone, the fatty acid distribution at the C-1 and C-2 positions of glycerol within phospholipids is continually in flux, owing to phospholipid degradation and the continuous phospholipid remodeling that occurs while these molecules are in membranes. PEs are neutral zwitterions at physiological pH. They mostly have palmitic or stearic acid on carbon 1 and a long chain unsaturated fatty acid (e.g. 18:2, 20:4 and 22:6) on carbon 2. PE synthesis can occur via two pathways. The first requires that ethanolamine be activated by phosphorylation and then coupled to CDP. The ethanolamine is then transferred from CDP-ethanolamine to phosphatidic acid to yield PE. The second involves the decarboxylation of PS. Plasmalogens are glycerol ether phospholipids. They are of two types, alkyl ether (-O-CH2-) and alkenyl ether (-O-CH=CH-). Dihydroxyacetone phosphate (DHAP) serves as the glycerol precursor for the synthesis of plasmalogens. Three major classes of plasmalogens have been identified: choline, ethanolamine and serine derivatives. Ethanolamine plasmalogen is prevalent in myelin. Choline plasmalogen is abundant in cardiac tissue. Usually, the highest proportion of the plasmalogen form is in the ethanolamine class with rather less in choline, and commonly little or none in other phospholipids such as phosphatidylinositol. In choline plasmalogens of most tissues, a higher proportion is often of the O-alkyl rather than the O-alkenyl form, but the reverse tends to be true in heart lipids. In animal tissues, the alkyl and alkenyl moieties in both non-polar and phospholipids tend to be rather simple in composition with 16:0, 18:0 and 18:1 (double bond in position 9) predominating. Ether analogues of triacylglycerols, i.e. 1-alkyldiacyl-sn-glycerols, are present at trace levels only if at all in most animal tissues, but they can be major components of some marine lipids.
Structure
Data?1582752906
Synonyms
ValueSource
1-(1-Enyl-oleoyl)-2-oleoyl-sn-glycero-3-phosphoethanolamineHMDB
(2-Aminoethoxy)[(2R)-2-[(9Z)-octadec-9-enoyloxy]-3-[(1Z,9Z)-octadeca-1,9-dien-1-yloxy]propoxy]phosphinateHMDB
1-(1Z,9Z-Octadecadienyl)-2-oleoyl-gpeHMDB
1-(1Z,9Z-Octadecadienyl)-2-oleoyl-sn-glycero-3-phosphoethanolamineHMDB
1-(1Z,9Z-Octadecadienyl)-2-oleoyl-sn-glycero-phosphatidylethanolamineHMDB
GPE(18:2/18:1)HMDB
GPE(36:3)HMDB
GPE(O-18:2(1Z,9Z)/18:1(9Z))HMDB
GPE(O-18:2(1Z,9Z)/18:1n9)HMDB
GPE(O-18:2(1Z,9Z)/18:1W9)HMDB
GPE(p-18:1(9Z)/18:1(9Z))HMDB
GPE(p-18:1(9Z)/18:1n9)HMDB
GPE(p-18:1(9Z)/18:1W9)HMDB
GPEtn(18:2/18:1)HMDB
GPEtn(36:3)HMDB
GPEtn(O-18:2(1Z,9Z)/18:1(9Z))HMDB
GPEtn(O-18:2(1Z,9Z)/18:1n9)HMDB
GPEtn(O-18:2(1Z,9Z)/18:1W9)HMDB
GPEtn(p-18:1(9Z)/18:1(9Z))HMDB
GPEtn(p-18:1(9Z)/18:1n9)HMDB
GPEtn(p-18:1(9Z)/18:1W9)HMDB
PE(18:2/18:1)HMDB
PE(36:3)HMDB
PE(O-18:2(1Z,9Z)/18:1(9Z))HMDB
PE(O-18:2(1Z,9Z)/18:1N9)HMDB
PE(O-18:2(1Z,9Z)/18:1W9)HMDB
PE(P-18:1(9Z)/18:1N9)HMDB
PE(P-18:1(9Z)/18:1W9)HMDB
Phosphatidylethanolamine(18:2/18:1)HMDB
Phosphatidylethanolamine(36:3)HMDB
Phosphatidylethanolamine(O-18:2(1Z,9Z)/18:1(9Z))HMDB
Phosphatidylethanolamine(O-18:2(1Z,9Z)/18:1n9)HMDB
Phosphatidylethanolamine(O-18:2(1Z,9Z)/18:1W9)HMDB
Phosphatidylethanolamine(p-18:1(9Z)/18:1(9Z))HMDB
Phosphatidylethanolamine(p-18:1(9Z)/18:1n9)HMDB
Phosphatidylethanolamine(p-18:1(9Z)/18:1W9)HMDB
Chemical FormulaC41H78NO7P
Average Molecular Weight728.0343
Monoisotopic Molecular Weight727.551590367
IUPAC Name(2-aminoethoxy)[(2R)-2-[(9Z)-octadec-9-enoyloxy]-3-[(1Z,9Z)-octadeca-1,9-dien-1-yloxy]propoxy]phosphinic acid
Traditional Name2-aminoethoxy(2R)-2-[(9Z)-octadec-9-enoyloxy]-3-[(1Z,9Z)-octadeca-1,9-dien-1-yloxy]propoxyphosphinic acid
CAS Registry NumberNot Available
SMILES
[H][C@@](CO\C=C/CCCCCC\C=C/CCCCCCCC)(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC
InChI Identifier
InChI=1S/C41H78NO7P/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-36-46-38-40(39-48-50(44,45)47-37-35-42)49-41(43)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2/h17-20,33,36,40H,3-16,21-32,34-35,37-39,42H2,1-2H3,(H,44,45)/b19-17-,20-18-,36-33-/t40-/m1/s1
InChI KeyCFANDHZPOSNKNO-UDHSZFGOSA-N
Chemical Taxonomy
Description Belongs to the class of organic compounds known as 1-(1z-alkenyl),2-acylglycerophosphoethanolamines. These are glycerophosphoethanolamines that carry exactly one acyl chain attached to the glycerol moiety through an ester linkage at the O2-position, and one 1Z-alkenyl chain attached through an ether linkage at the O1-position.
KingdomOrganic compounds
Super ClassLipids and lipid-like molecules
ClassGlycerophospholipids
Sub ClassGlycerophosphoethanolamines
Direct Parent1-(1Z-alkenyl),2-acylglycerophosphoethanolamines
Alternative Parents
Substituents
  • 1-(1z-alkenyl),2-acylglycerophosphoethanolamine
  • Glycerol vinyl ether
  • Phosphoethanolamine
  • Fatty acid ester
  • Dialkyl phosphate
  • Fatty acyl
  • Alkyl phosphate
  • Organic phosphoric acid derivative
  • Phosphoric acid ester
  • Amino acid or derivatives
  • Carboxylic acid ester
  • Carboxylic acid derivative
  • Monocarboxylic acid or derivatives
  • Organic oxide
  • Organooxygen compound
  • Organonitrogen compound
  • Organic nitrogen compound
  • Primary amine
  • Primary aliphatic amine
  • Organic oxygen compound
  • Amine
  • Carbonyl group
  • Organopnictogen compound
  • Hydrocarbon derivative
  • Aliphatic acyclic compound
Molecular FrameworkAliphatic acyclic compounds
External DescriptorsNot Available
Ontology
Physiological effect
Disposition
Process
Role
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting PointNot AvailableNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic PropertiesNot Available
Predicted Molecular Properties
PropertyValueSource
Water Solubility6.9e-05 g/LALOGPS
logP9.3ALOGPS
logP11.9ChemAxon
logS-7ALOGPS
pKa (Strongest Acidic)1.87ChemAxon
pKa (Strongest Basic)10ChemAxon
Physiological Charge0ChemAxon
Hydrogen Acceptor Count5ChemAxon
Hydrogen Donor Count2ChemAxon
Polar Surface Area117.31 ŲChemAxon
Rotatable Bond Count40ChemAxon
Refractivity211.98 m³·mol⁻¹ChemAxon
Polarizability89.37 ųChemAxon
Number of Rings0ChemAxon
BioavailabilityNoChemAxon
Rule of FiveNoChemAxon
Ghose FilterNoChemAxon
Veber's RuleNoChemAxon
MDDR-like RuleNoChemAxon
Predicted Chromatographic Properties

Predicted Collision Cross Sections

PredictorAdduct TypeCCS Value (Å2)Reference
DarkChem[M+H]+278.97731661259
DarkChem[M-H]-263.98631661259
DeepCCS[M+H]+281.34130932474
DeepCCS[M-H]-278.98330932474
DeepCCS[M-2H]-311.86930932474
DeepCCS[M+Na]+288.20430932474
AllCCS[M+H]+281.432859911
AllCCS[M+H-H2O]+281.232859911
AllCCS[M+NH4]+281.532859911
AllCCS[M+Na]+281.532859911
AllCCS[M-H]-267.632859911
AllCCS[M+Na-2H]-274.032859911
AllCCS[M+HCOO]-281.132859911

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
PE(P-18:1(9Z)/18:1(9Z))[H][C@@](CO\C=C/CCCCCC\C=C/CCCCCCCC)(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC4934.1Standard polar33892256
PE(P-18:1(9Z)/18:1(9Z))[H][C@@](CO\C=C/CCCCCC\C=C/CCCCCCCC)(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC4743.9Standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z))[H][C@@](CO\C=C/CCCCCC\C=C/CCCCCCCC)(COP(O)(=O)OCCN)OC(=O)CCCCCCC\C=C/CCCCCCCC5182.6Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
PE(P-18:1(9Z)/18:1(9Z)),1TMS,isomer #1CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC5141.6Semi standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),1TMS,isomer #1CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC4390.6Standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),1TMS,isomer #1CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC6331.9Standard polar33892256
PE(P-18:1(9Z)/18:1(9Z)),1TMS,isomer #2CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC5205.4Semi standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),1TMS,isomer #2CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC4624.2Standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),1TMS,isomer #2CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC6107.0Standard polar33892256
PE(P-18:1(9Z)/18:1(9Z)),2TMS,isomer #1CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(OCCN[Si](C)(C)C)O[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC5127.4Semi standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),2TMS,isomer #1CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(OCCN[Si](C)(C)C)O[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC4552.0Standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),2TMS,isomer #1CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(OCCN[Si](C)(C)C)O[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC5128.8Standard polar33892256
PE(P-18:1(9Z)/18:1(9Z)),2TMS,isomer #2CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(O)OCCN([Si](C)(C)C)[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC5339.9Semi standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),2TMS,isomer #2CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(O)OCCN([Si](C)(C)C)[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC4616.8Standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),2TMS,isomer #2CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(O)OCCN([Si](C)(C)C)[Si](C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC5819.4Standard polar33892256
PE(P-18:1(9Z)/18:1(9Z)),1TBDMS,isomer #1CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C(C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC5361.6Semi standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),1TBDMS,isomer #1CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C(C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC4445.7Standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),1TBDMS,isomer #1CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(OCCN)O[Si](C)(C)C(C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC6300.9Standard polar33892256
PE(P-18:1(9Z)/18:1(9Z)),1TBDMS,isomer #2CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C(C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC5414.3Semi standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),1TBDMS,isomer #2CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C(C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC4707.1Standard non polar33892256
PE(P-18:1(9Z)/18:1(9Z)),1TBDMS,isomer #2CCCCCCCC/C=C\CCCCCC/C=C\OC[C@H](COP(=O)(O)OCCN[Si](C)(C)C(C)(C)C)OC(=O)CCCCCCC/C=C\CCCCCCCC6040.8Standard polar33892256
Spectra

MS/MS Spectra

Spectrum TypeDescriptionSplash KeyDeposition DateSourceView
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PE(P-18:1(9Z)/18:1(9Z)) 10V, Positive-QTOFsplash10-004i-3200024900-c7d3d0031f73690d15bf2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PE(P-18:1(9Z)/18:1(9Z)) 20V, Positive-QTOFsplash10-059l-8100095000-2cffa36371d52cf7edbb2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PE(P-18:1(9Z)/18:1(9Z)) 40V, Positive-QTOFsplash10-0006-2924400000-3301bb5f0f78142c17cd2021-09-23Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PE(P-18:1(9Z)/18:1(9Z)) 10V, Negative-QTOFsplash10-004i-2400001900-e76f6654a92c282b5c1c2021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PE(P-18:1(9Z)/18:1(9Z)) 20V, Negative-QTOFsplash10-00ov-3660900300-07fffcfe25dfce219c722021-09-25Wishart LabView Spectrum
Predicted LC-MS/MSPredicted LC-MS/MS Spectrum - PE(P-18:1(9Z)/18:1(9Z)) 40V, Negative-QTOFsplash10-002f-9730300000-7a133b55e8b4da14ff302021-09-25Wishart LabView Spectrum
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Feces
Tissue Locations
  • All Tissues
  • Brain
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
FecesDetected but not QuantifiedNot QuantifiedNewborn (0-30 days old)Not Specified
Premature neonates
details
FecesDetected but not QuantifiedNot QuantifiedNewborn (0-30 days old)Not Specified
Premature neonates
details
Predicted Concentrations
BiospecimenValueOriginal ageOriginal sexOriginal conditionComments
Blood9.369 +/- 7.422 uMAdult (>18 years old)BothNormal (Upper Limit)Concentration data updated from parsing Nick's...
Blood0.804 +/- 0.196 uMAdult (>18 years old)BothNormal (Most Probable)Concentration data updated from parsing Nick's...
Associated Disorders and Diseases
Disease ReferencesNone
Associated OMIM IDsNone
DrugBank IDNot Available
Phenol Explorer Compound IDNot Available
FooDB IDFDB028164
KNApSAcK IDNot Available
Chemspider ID24769325
KEGG Compound IDNot Available
BioCyc IDNot Available
BiGG IDNot Available
Wikipedia LinkNot Available
METLIN IDNot Available
PubChem Compound53480897
PDB IDNot Available
ChEBI IDNot Available
Food Biomarker OntologyNot Available
VMH IDNot Available
MarkerDB IDNot Available
Good Scents IDNot Available
References
Synthesis ReferenceNot Available
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Simons K, Toomre D: Lipid rafts and signal transduction. Nat Rev Mol Cell Biol. 2000 Oct;1(1):31-9. [PubMed:11413487 ]
  2. Watson AD: Thematic review series: systems biology approaches to metabolic and cardiovascular disorders. Lipidomics: a global approach to lipid analysis in biological systems. J Lipid Res. 2006 Oct;47(10):2101-11. Epub 2006 Aug 10. [PubMed:16902246 ]
  3. Sethi JK, Vidal-Puig AJ: Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation. J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20. [PubMed:17374880 ]
  4. Lingwood D, Simons K: Lipid rafts as a membrane-organizing principle. Science. 2010 Jan 1;327(5961):46-50. doi: 10.1126/science.1174621. [PubMed:20044567 ]
  5. Divecha N, Irvine RF: Phospholipid signaling. Cell. 1995 Jan 27;80(2):269-78. [PubMed:7834746 ]
  6. Cevc, Gregor (1993). Phospholipids Handbook. Marcel Dekker.
  7. Gunstone, Frank D., John L. Harwood, and Albert J. Dijkstra (2007). The lipid handbook with CD-ROM. CRC Press.

Only showing the first 10 proteins. There are 43 proteins in total.

Enzymes

General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
Gene Name:
PLA2G5
Uniprot ID:
P39877
Molecular weight:
15674.065
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.
Gene Name:
PLA2G2F
Uniprot ID:
Q9BZM2
Molecular weight:
23256.29
General function:
Involved in metabolic process
Specific function:
Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Gene Name:
PLA2G4A
Uniprot ID:
P47712
Molecular weight:
85210.19
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.
Gene Name:
PLA2G1B
Uniprot ID:
P04054
Molecular weight:
16359.535
General function:
Involved in phospholipase A2 activity
Specific function:
Not known; does not seem to have catalytic activity.
Gene Name:
PLA2G12B
Uniprot ID:
Q9BX93
Molecular weight:
Not Available
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.
Gene Name:
PLA2G10
Uniprot ID:
O15496
Molecular weight:
18153.04
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.
Gene Name:
PLA2G2E
Uniprot ID:
Q9NZK7
Molecular weight:
15988.525
General function:
Involved in metabolic process
Specific function:
Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.
Gene Name:
PLA2G6
Uniprot ID:
O60733
Molecular weight:
84092.635
General function:
Involved in phospholipase A2 activity
Specific function:
PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. L-alpha-1-palmitoyl-2-linoleoyl phosphatidylethanolamine is more efficiently hydrolyzed than the other phospholipids examined.
Gene Name:
PLA2G2D
Uniprot ID:
Q9UNK4
Molecular weight:
16546.1
General function:
Involved in protein binding
Specific function:
May have a role in signal-induced cytoskeletal regulation and/or endocytosis (By similarity).
Gene Name:
PLD2
Uniprot ID:
O14939
Molecular weight:
104656.485

Only showing the first 10 proteins. There are 43 proteins in total.