Search Results for metabolites

Matched description: … It can also compete with endogenous arachidonic acid for 5-lipoxygenation in stimulated human neutrophils ... By providing competing substrates for neutrophil 5-lipoxygenase, platelets might contribute to the antiinflammatory ... 12-HEPE is hydroxy derivative of 12-lipoxygenase metabolites of Eicosapentaenoic acid (EPA). 12S-HEPE …

Matched description: … Both the R(+) and S(-) enantiomers are pharmacologically active as 5-lipoxygenase inhibitors in in vitro ... Zileuton relieves such symptoms through its selective inhibition of 5-lipoxygenase, the enzyme that catalyzes ... the formation of leukotrienes from arachidonic acid. …

Matched synonyms: … 12(S)-Hydroxy-5(Z),8(Z),10(e),14(Z)-eicosatetraenoate ... 12(S)-Hydroxy-5(Z),8(Z),10(e),14(Z)-eicosatetraenoic acid …
Matched description: … metabolite of arachidonic acid. 5-Lipoxygenase (LO)-derived leukotrienes are involved in inflammatory ... 12-Hydroxyeicosatetraenoic acid (CAS: 71030-37-0), also known as 12-HETE, is an eicosanoid, a 5-lipoxygenase ... acid metabolism associated with increased generation of arachidonic acid metabolites such as 12-HETE …

Matched description: … Genetic studies indicated that 12R-lipoxygenase (12R-LOX) or epidermal lipoxygenase-3 (eLOX3) was mutated ... 12(R)-HPETE is a hydroperoxyeicosatetraenoic acid eicosanoid derived from arachidonic acid. ... The epidermal lipoxygenases 12R-LOX and eLOX3 act in sequence to convert arachidonic acid via 12(R)-HPETE …

Matched description: … ) pathway of arachidonic acid (AA). ... 11,14,15-trihydroxyeicosatrienoic acid (11,14,15-THETA) is a metabolite of the 15-lipoxygenase (15-LO …

Matched description: … )-HPODE) is one of the primary products of the major polyunsaturated fatty acids (linoleic acid and arachidonic ... acid) from the 15-lipoxygenase pathway (EC 1.13.11.31). 13(S)-HPODE is a rather unstable metabolite ... alkoxy radicals (via homolytic cleavage of the peroxy group), forms of dihydro(pero)xy fatty acids (via lipoxygenase-catalysed …

Matched synonyms: … Arachidonic acid omega-9 hydroperoxide …
Matched description: … the 5-lipoxygenase pathway. ... 12-HPETE is one of the six monohydroperoxy fatty acids produced by the non-enzymatic oxidation of arachidonic ... A family of biologically active compounds derived from arachidonic acid by oxidative metabolism through …

Matched description: … The conversion of arachidonic acid to HETE can be catalyzed via lipoxygenase ,cyclooxygenase or P-450 ... identified as omega-hydroxy derivatives and 10-HETE is one of the major products of NADPH-dependent arachidonic …

Matched description: … 8S-HPETE is metabolized from arachidonic acid by the enzyme 8S-lipoxygenase (8-LOX in mouse, ALOX15 and …

Matched synonyms: … Arachidonic acid 15-hydroperoxide …
Matched description: … Reactive oxygen species convert the omega-6 polyunsaturated fatty acid arachidonic acid into (15-HPETE ... Lipoxygenase(s) and Na+-K+-ATPase of brain microvessels may play a significant role in the occurrence ... HPETE decomposition. 15(S)-HPETE initiates apoptosis in vascular smooth muscle cells. 15(S)-HPETE is a lipoxygenase …

Matched description: … A potent lipoxygenase inhibitor that interferes with arachidonic acid metabolism. ... Although the exact mechanism of action is not known, studies have shown that masoprocol is a potent 5- ... lipoxygenase inhibitor and has antiproliferative activity against keratinocytes in tissue culture, but …

Matched description: … It differs from arachidonic acid (5,8,11,14-eicosatetraenoic acid) only at position 5. 8,11,14-Eicosatrienoic ... DGLA competes with arachadonic acid for COX and lipoxygenase, inhibiting the production of arachadonic …

Matched synonyms: … 5(S),6(R),15(S)-Trihydroxyeicosa-7E,9E,11Z,13E-tetraenoate ... 5(S),6(R),15(S)-Trihydroxyeicosa-7E,9E,11Z,13E-tetraenoic acid …
Matched description: … Lipoxin A4 (LXA4) was first identified in 1984 by Serhan and colleagues as 5-lipoxygenase interaction ... Lipoxins (LXs) or the lipoxygenase interaction products are generated from arachidonic acid via sequential …

Matched description: … (LO) pathway. 12-LO is the major arachidonic acid (AA) oxygenation pathway in epidermal cells with total ... oxo-eicosatetraenoic acid (12-oxo-ETE), hepoxilin A3 (HxA3), and hepoxilin B3 (HxB3) through the 12- Lipoxygenase …

Matched description: … In the presence of lipoxygenase, Mead acid can form various hydroxy products (HETE). ... During dietary EFA insufficiency, especially arachidonic acid deficiency, the body will make Mead acid …

Matched synonyms: … 5-ASA ... Novo 5 asa ... Novo-5 asa …
Matched iupac: … 5-amino-2-hydroxybenzoic acid …
Matched description: … , and through the lipoxygenase pathways, i.e., leukotrienes and hydroxyeicosatetraenoic acids, is increased ... Mucosal production of arachidonic acid metabolites, both through the cyclooxygenase pathways, i.e., prostanoids …

Matched description: … of action in vivo and showes that in addition to its effects on the 5-lipoxygenase pathway, it ... It confirmed the important role of the arachidonic acid metabolic pathway in diethylcarbamazine's mechanism …

Matched synonyms: … 5(S),12(R)-Dihydroxy-6,8,10,14-(trans,trans,trans,cis)-eicosatetraenoic acid ... 5(S),12(R)-Dihydroxy-6,8,10,14-(trans,trans,trans,cis)-eicosatetraenoate …
Matched description: … Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). ... A greater increase in LTB4 and 6-trans-LTB4 (one of its hydroxylated 5-lipoxygenase metabolic derivatives ... 5-LO. …

Matched synonyms: … 5(S)-5,6-Oxido-7,9-trans-11,14-cis-eicosatetraenoate ... 5(S)-5,6-Oxido-7,9-trans-11,14-cis-eicosatetraenoic acid …
Matched description: … Lipoxygenase (5-LO) catalyzes the two-step conversion of arachidonic acid to LTA4.The first step consists ... of the oxidation of arachidonic acid to the unstable intermediate 5-hydroperoxyeicosatetraenoic acid ... (5-HPETE), and the second step is the dehydration of 5-HPETE to form LTA4. …

Matched synonyms: … 5-cis,8-cis,11-cis,14-cis-Eicosatetraenoate ... 5-cis,8-cis,11-cis,14-cis-Eicosatetraenoic acid ... Arachidonic acid, sodium salt …
Matched name: … Arachidonic acid …
Matched description: … Arachidonate lipoxygenase (ALOX) enzymes metabolize arachidonic acid to generate potent inflammatory ... Arachidonic acid is a polyunsaturated, essential fatty acid that has a 20-carbon chain as a backbone ... Arachidonic acid mediates inflammation and the functioning of several organs and systems either directly …

Matched description: … Hepoxilin A3 is an electrophilic eicosanoids synthesized during arachidonic acid oxidative metabolism ... GSH-adducts have been observed with molecules synthesized through the 12-lipoxygenase pathway. …

Matched description: … ) pathway of arachidonic acid (AA). 11,12,15-THETA is an endothelium-derived relaxing factor. ... 11,12,15-trihydroxyeicosatrienoic acid (11,12,15-THETA) is a metabolite of the 15-lipoxygenase (15-LO …

Matched description: … (LO) pathway. 12-LO is the major arachidonic acid (AA) oxygenation pathway in epidermal cells with total ... oxo-eicosatetraenoic acid (12-oxo-ETE), hepoxilin A3 (HxA3), and hepoxilin B3 (HxB3) through the 12- Lipoxygenase …

Matched description: … 12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. …

Matched description: … Leukotrienes are metabolites of arachidonic acid derived from the action of 5-LO (5-lipoxygenase). ... 5-LO. ... The immediate product of 5-LO is LTA4 (leukotriene A4), which is enzymatically converted into either …