Showing metabocard for Myristic acid (HMDB0000806)

General function:

Involved in transferase activity

Specific function:

Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.

Gene Name:

FASN

Uniprot ID:

P49327

Molecular weight:

273424.06

Reactions

General function:

Involved in phospholipase A2 activity

Specific function:

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L-alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L-alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.

Gene Name:

PLA2G5

Uniprot ID:

P39877

Molecular weight:

15674.065

General function:

Involved in phospholipase A2 activity

Specific function:

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Hydrolyzes phosphatidylglycerol versus phosphatidylcholine with a 15-fold preference.

Gene Name:

PLA2G2F

Uniprot ID:

Q9BZM2

Molecular weight:

23256.29

General function:

Involved in metabolic process

Specific function:

Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.

Gene Name:

PLA2G4A

Uniprot ID:

P47712

Molecular weight:

85210.19

General function:

Involved in phospholipase A2 activity

Specific function:

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides.

Gene Name:

PLA2G1B

Uniprot ID:

P04054

Molecular weight:

16359.535

General function:

Involved in phospholipase A2 activity

Specific function:

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a powerful potency for releasing arachidonic acid from cell membrane phospholipids. Prefers phosphatidylethanolamine and phosphatidylcholine liposomes to those of phosphatidylserine.

Gene Name:

PLA2G10

Uniprot ID:

O15496

Molecular weight:

18153.04

General function:

Involved in sugar binding

Specific function:

Has lysophospholipase activity.

Gene Name:

LGALS13

Uniprot ID:

Q9UHV8

Molecular weight:

16118.44

General function:

Involved in phospholipase A2 activity

Specific function:

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Has a preference for arachidonic-containing phospholipids.

Gene Name:

PLA2G2E

Uniprot ID:

Q9NZK7

Molecular weight:

15988.525

General function:

Involved in phospholipase A2 activity

Specific function:

PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides. Does not exhibit detectable activity toward sn-2-arachidonoyl- or linoleoyl-phosphatidylcholine or -phosphatidylethanolamine.

Gene Name:

PLA2G12A

Uniprot ID:

Q9BZM1

Molecular weight:

21066.99

General function:

Involved in metabolic process

Specific function:

Catalyzes the release of fatty acids from phospholipids. It has been implicated in normal phospholipid remodeling, nitric oxide-induced or vasopressin-induced arachidonic acid release and in leukotriene and prostaglandin production. May participate in fas mediated apoptosis and in regulating transmembrane ion flux in glucose-stimulated B-cells. Has a role in cardiolipin (CL) deacylation. Required for both speed and directionality of monocyte MCP1/CCL2-induced chemotaxis through regulation of F-actin polymerization at the pseudopods. Isoform ankyrin-iPLA2-1 and isoform ankyrin-iPLA2-2, which lack the catalytic domain, are probably involved in the negative regulation of iPLA2 activity.

Gene Name:

PLA2G6

Uniprot ID:

O60733

Molecular weight:

84092.635